SPENOLIMYCIN, A NEW SPECTINOMYCIN-TYPE ANTIBIOTIC: II. ISOLATION AND STRUCTURE DETERMINATION

A new water-soluble, basic antibiotic has been isolated from the fermentation beers of Streptomyces gilvospiralis sp. nov. The structure of the antibiotic has been deduced from spectral studies and confirmed by chemical degradation to spectinomycin. This structure, 3'-O -methylspectinomycin-3&#...

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Veröffentlicht in:	Journal of antibiotics 1984, Vol.37(12), pp.1519-1524
Hauptverfasser:	MCALPINE, JAMES B., BRILL, GREGORY M., SPANTON, STEPHEN G., MUELLER, SANDRA L., STANASZEK, RUTH S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Biological and medical sciences Biotechnology Chemical Phenomena Chemistry fermentation Fundamental and applied biological sciences. Psychology General pharmacology Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Magnetic Resonance Spectroscopy Medical sciences Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Production of active biomolecules Spectinomycin - analogs & derivatives Spectinomycin - isolation & purification spenolimycin Streptomyces - metabolism Streptomyces gilvospiralis
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Beschreibung
Zusammenfassung:	A new water-soluble, basic antibiotic has been isolated from the fermentation beers of Streptomyces gilvospiralis sp. nov. The structure of the antibiotic has been deduced from spectral studies and confirmed by chemical degradation to spectinomycin. This structure, 3'-O -methylspectinomycin-3', 4'-enol ether has led to the name spenolimycin.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.37.1519