Comparative study of gallopamil versus nifedipine in patients with ischemic heart disease
In order to compare the anti-ischemic activity of gallopamil and nifedipine, a cross-over, double-blind, randomised trial was carried out in 30 male out-patients with a history of stable exertional angina, proven coronary disease and a positive stress test (ST-segment depression ≥ 1 mm). After a fir...
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Veröffentlicht in: | International journal of cardiology 1993-07, Vol.40 (2), p.127-133 |
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creator | De Miguel, Enrique Molinero Arruti, Alberto Salcedo Gorostiza, JoséDomingo Sagastagoitia Ezkurdia, Miguel Ma-Iriarte Vidal, Pilar Fernandez Quintana, Javier Velasco García, Jesús Garrido |
description | In order to compare the anti-ischemic activity of gallopamil and nifedipine, a cross-over, double-blind, randomised trial was carried out in 30 male out-patients with a history of stable exertional angina, proven coronary disease and a positive stress test (ST-segment depression ≥ 1 mm). After a first 1-week wash-out period on placebo, the patients were randomised to gallopamil, 150 mg/day (50, 50 and 50) or nifedipine, 30 mg/day (10, 10 and 10) for 28 days. After a second 1-week wash-out period active treatments were crossed for another 28 days. At the end of each drug or placebo period, a physical examination, laboratory tests and a stress test were performed. Oral short-acting nitrates were permitted throughout the trial periods. Twenty-one patients finished all periods of the study. Both drugs reduced the maximum ST-segment depression during the exercise test: from 2.45 ± 0.97 mm (placebo) to 1.95 ± 0.82 mm (gallopamil,
P < 0.05) and from 2.50 ± 0.93 mm (placebo) to 1.75 ± 0.84 mm (nifedipine,
P < 0.05). Gallopamil but not nifedipine increased stress tolerance significantly: from 486 ± 156 s (placebo) to 598 ± 138 s (gallopamil,
P < 0.05) and from 509 ± 113 s (placebo) to 567 ± 191 s (nifedipine, NS). No significant differences were found between drugs. Both calcium antagonists, gallopamil and nifedipine, showed similar efficacy in treating myocardial ischemia. |
doi_str_mv | 10.1016/0167-5273(93)90275-L |
format | Article |
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P < 0.05) and from 2.50 ± 0.93 mm (placebo) to 1.75 ± 0.84 mm (nifedipine,
P < 0.05). Gallopamil but not nifedipine increased stress tolerance significantly: from 486 ± 156 s (placebo) to 598 ± 138 s (gallopamil,
P < 0.05) and from 509 ± 113 s (placebo) to 567 ± 191 s (nifedipine, NS). No significant differences were found between drugs. Both calcium antagonists, gallopamil and nifedipine, showed similar efficacy in treating myocardial ischemia.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/0167-5273(93)90275-L</identifier><identifier>PMID: 8349375</identifier><identifier>CODEN: IJCDD5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Aged ; Analysis of Variance ; Antianginal agents. Coronary vasodilator agents ; Biological and medical sciences ; Blood Pressure - drug effects ; Cardiovascular system ; Double-Blind Method ; Electrocardiography - drug effects ; Exercise - physiology ; Gallopamil ; Gallopamil - pharmacology ; Gallopamil - therapeutic use ; Heart Rate - drug effects ; Humans ; Ischemic heart disease ; Male ; Medical sciences ; Middle Aged ; Myocardial Ischemia - drug therapy ; Myocardial Ischemia - physiopathology ; Nifedipine ; Nifedipine - pharmacology ; Nifedipine - therapeutic use ; Pharmacology. Drug treatments</subject><ispartof>International journal of cardiology, 1993-07, Vol.40 (2), p.127-133</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c335t-eceb819f0f858a7b5d62b0dabed31f8b0d1affcae1f6d94ee7d50ce13ae947c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0167-5273(93)90275-L$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4821008$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8349375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Miguel, Enrique Molinero</creatorcontrib><creatorcontrib>Arruti, Alberto Salcedo</creatorcontrib><creatorcontrib>Gorostiza, JoséDomingo Sagastagoitia</creatorcontrib><creatorcontrib>Ezkurdia, Miguel Ma-Iriarte</creatorcontrib><creatorcontrib>Vidal, Pilar Fernandez</creatorcontrib><creatorcontrib>Quintana, Javier Velasco</creatorcontrib><creatorcontrib>García, Jesús Garrido</creatorcontrib><title>Comparative study of gallopamil versus nifedipine in patients with ischemic heart disease</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>In order to compare the anti-ischemic activity of gallopamil and nifedipine, a cross-over, double-blind, randomised trial was carried out in 30 male out-patients with a history of stable exertional angina, proven coronary disease and a positive stress test (ST-segment depression ≥ 1 mm). After a first 1-week wash-out period on placebo, the patients were randomised to gallopamil, 150 mg/day (50, 50 and 50) or nifedipine, 30 mg/day (10, 10 and 10) for 28 days. After a second 1-week wash-out period active treatments were crossed for another 28 days. At the end of each drug or placebo period, a physical examination, laboratory tests and a stress test were performed. Oral short-acting nitrates were permitted throughout the trial periods. Twenty-one patients finished all periods of the study. Both drugs reduced the maximum ST-segment depression during the exercise test: from 2.45 ± 0.97 mm (placebo) to 1.95 ± 0.82 mm (gallopamil,
P < 0.05) and from 2.50 ± 0.93 mm (placebo) to 1.75 ± 0.84 mm (nifedipine,
P < 0.05). Gallopamil but not nifedipine increased stress tolerance significantly: from 486 ± 156 s (placebo) to 598 ± 138 s (gallopamil,
P < 0.05) and from 509 ± 113 s (placebo) to 567 ± 191 s (nifedipine, NS). No significant differences were found between drugs. Both calcium antagonists, gallopamil and nifedipine, showed similar efficacy in treating myocardial ischemia.</description><subject>Adult</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Antianginal agents. Coronary vasodilator agents</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular system</subject><subject>Double-Blind Method</subject><subject>Electrocardiography - drug effects</subject><subject>Exercise - physiology</subject><subject>Gallopamil</subject><subject>Gallopamil - pharmacology</subject><subject>Gallopamil - therapeutic use</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Ischemic heart disease</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Ischemia - drug therapy</subject><subject>Myocardial Ischemia - physiopathology</subject><subject>Nifedipine</subject><subject>Nifedipine - pharmacology</subject><subject>Nifedipine - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQQEVpSZw0_6ABHUpoD9tK1sqSLoFgmiZg6CU55CS00qhW2a9qdl3y7yNj42NhhhmYN8PwCPnE2TfO-Op7SVXJpRJfjPhq2FLJavOOLLhWdcWVrN-TxQk5JxeIfxhjtTH6jJxpURuh5IK8rIdudNlNaQcUpzm80iHS365th9F1qaU7yDgj7VOEkMbUA009HQsP_YT0X5q2NKHfQpc83YLLEw0JwSF8JB-iaxGujvWSPN__eFo_VJtfPx_Xd5vKCyGnCjw0mpvIopbaqUaG1bJhwTUQBI-6tNzF6B3wuAqmBlBBMg9cODC18lxckpvD3TEPf2fAyXblIWhb18Mwo1VSa8a5KGB9AH0eEDNEO-bUufxqObN7o3avy-51WVNib9Ruytr18f7cdBBOS0eFZf75OHfoXRuz633CE1brJWdMF-z2gEFxsUuQLfri0BerGfxkw5D-_8cbktqU7A</recordid><startdate>19930701</startdate><enddate>19930701</enddate><creator>De Miguel, Enrique Molinero</creator><creator>Arruti, Alberto Salcedo</creator><creator>Gorostiza, JoséDomingo Sagastagoitia</creator><creator>Ezkurdia, Miguel Ma-Iriarte</creator><creator>Vidal, Pilar Fernandez</creator><creator>Quintana, Javier Velasco</creator><creator>García, Jesús Garrido</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930701</creationdate><title>Comparative study of gallopamil versus nifedipine in patients with ischemic heart disease</title><author>De Miguel, Enrique Molinero ; Arruti, Alberto Salcedo ; Gorostiza, JoséDomingo Sagastagoitia ; Ezkurdia, Miguel Ma-Iriarte ; Vidal, Pilar Fernandez ; Quintana, Javier Velasco ; García, Jesús Garrido</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-eceb819f0f858a7b5d62b0dabed31f8b0d1affcae1f6d94ee7d50ce13ae947c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Antianginal agents. Coronary vasodilator agents</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiovascular system</topic><topic>Double-Blind Method</topic><topic>Electrocardiography - drug effects</topic><topic>Exercise - physiology</topic><topic>Gallopamil</topic><topic>Gallopamil - pharmacology</topic><topic>Gallopamil - therapeutic use</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Ischemic heart disease</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Ischemia - drug therapy</topic><topic>Myocardial Ischemia - physiopathology</topic><topic>Nifedipine</topic><topic>Nifedipine - pharmacology</topic><topic>Nifedipine - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Miguel, Enrique Molinero</creatorcontrib><creatorcontrib>Arruti, Alberto Salcedo</creatorcontrib><creatorcontrib>Gorostiza, JoséDomingo Sagastagoitia</creatorcontrib><creatorcontrib>Ezkurdia, Miguel Ma-Iriarte</creatorcontrib><creatorcontrib>Vidal, Pilar Fernandez</creatorcontrib><creatorcontrib>Quintana, Javier Velasco</creatorcontrib><creatorcontrib>García, Jesús Garrido</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Miguel, Enrique Molinero</au><au>Arruti, Alberto Salcedo</au><au>Gorostiza, JoséDomingo Sagastagoitia</au><au>Ezkurdia, Miguel Ma-Iriarte</au><au>Vidal, Pilar Fernandez</au><au>Quintana, Javier Velasco</au><au>García, Jesús Garrido</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative study of gallopamil versus nifedipine in patients with ischemic heart disease</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>1993-07-01</date><risdate>1993</risdate><volume>40</volume><issue>2</issue><spage>127</spage><epage>133</epage><pages>127-133</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><coden>IJCDD5</coden><abstract>In order to compare the anti-ischemic activity of gallopamil and nifedipine, a cross-over, double-blind, randomised trial was carried out in 30 male out-patients with a history of stable exertional angina, proven coronary disease and a positive stress test (ST-segment depression ≥ 1 mm). After a first 1-week wash-out period on placebo, the patients were randomised to gallopamil, 150 mg/day (50, 50 and 50) or nifedipine, 30 mg/day (10, 10 and 10) for 28 days. After a second 1-week wash-out period active treatments were crossed for another 28 days. At the end of each drug or placebo period, a physical examination, laboratory tests and a stress test were performed. Oral short-acting nitrates were permitted throughout the trial periods. Twenty-one patients finished all periods of the study. Both drugs reduced the maximum ST-segment depression during the exercise test: from 2.45 ± 0.97 mm (placebo) to 1.95 ± 0.82 mm (gallopamil,
P < 0.05) and from 2.50 ± 0.93 mm (placebo) to 1.75 ± 0.84 mm (nifedipine,
P < 0.05). Gallopamil but not nifedipine increased stress tolerance significantly: from 486 ± 156 s (placebo) to 598 ± 138 s (gallopamil,
P < 0.05) and from 509 ± 113 s (placebo) to 567 ± 191 s (nifedipine, NS). No significant differences were found between drugs. Both calcium antagonists, gallopamil and nifedipine, showed similar efficacy in treating myocardial ischemia.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8349375</pmid><doi>10.1016/0167-5273(93)90275-L</doi><tpages>7</tpages></addata></record> |
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subjects | Adult Aged Analysis of Variance Antianginal agents. Coronary vasodilator agents Biological and medical sciences Blood Pressure - drug effects Cardiovascular system Double-Blind Method Electrocardiography - drug effects Exercise - physiology Gallopamil Gallopamil - pharmacology Gallopamil - therapeutic use Heart Rate - drug effects Humans Ischemic heart disease Male Medical sciences Middle Aged Myocardial Ischemia - drug therapy Myocardial Ischemia - physiopathology Nifedipine Nifedipine - pharmacology Nifedipine - therapeutic use Pharmacology. Drug treatments |
title | Comparative study of gallopamil versus nifedipine in patients with ischemic heart disease |
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