Effects of high-molecular-weight hyaluronates on the functions of guinea pig polymorphonuclear leukocytes

The effect of hyaluronate (HA) with a molecular weight of 1,900,000 (HA190) purified from products of Streptococcus equi on various functions of guinea pig peritoneal polymorphonuclear leukocytes (PMNs) was examined. HA190 effectively inhibited both the chemotactic activity of PMNs for a chemotactic...

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Veröffentlicht in:	Seminars in arthritis and rheumatism 1993-06, Vol.22 (6), p.4-8
Hauptverfasser:	Tamoto, Koichi, Tada, Masahito, Shimada, Sachiyo, Nochi, Hiromi, Mori, Yoki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemotaxis Chemotaxis - drug effects Guinea Pigs Hyaluronates Hyaluronic Acid - chemistry Hyaluronic Acid - pharmacology leukocytes Molecular Weight Neutrophils - drug effects Neutrophils - metabolism Neutrophils - physiology Peritoneal Cavity - cytology phagocytosis Phagocytosis - drug effects superoxide generation Superoxides - metabolism
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