Specific binding of [ 3H]diazepam in mouse glioblastoma the influence of clonazepam and Ro 5–4864 on [ 3H]diazepam binding

The reversible specific binding of [ 3H]diazepam was observed by a radioligand method in homogenates of cultured cells of mouse glioblastoma. It was characterized by an equilibrium dissociation constant K d = 91 ± 5 nM and the number of maximal binding sites (B max) of 1006 ± 100 fmol/mg protein. Th...

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Veröffentlicht in:	Neuroscience letters 1984-12, Vol.52 (3), p.259-262
Hauptverfasser:	Zlobina, Galina P., Kondakova, Lidia I., Khalansky, Alexander S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals benzodiazepine receptors Benzodiazepinones - pharmacology Binding Sites Biological and medical sciences Cell Line clonazepam Clonazepam - pharmacology diazepam Diazepam - metabolism glial cell culture Glioma Medical sciences Mice mouse glioblastoma Neuroglia - metabolism Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Ro 5–4864
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