Autoradiography of d-2-[ 3H]amino-5-phosphonopentanoate binding sites in rat brain

Quantitative autoradiographic techniques were used to obtain a preliminary description of the pharmacological characteristics and anatomical distribution of the selective N-methyl- d-aspartate (NMDA) receptor antagonist d-2-[ 3H]amino-5-phosphonopentanoate ( d-[ 3H]AP5). Binding sites exhibit the ap...

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Veröffentlicht in:	Neuroscience letters 1984-12, Vol.52 (3), p.253-258
Hauptverfasser:	Monaghan, D.T., Yao, D., Olverman, H.J., Watkins, J.C., Cotman, C.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-amino-5-phosphonopentanoate 2-Amino-5-phosphonovalerate Amino Acids - pharmacology Animals Autoradiography Binding Sites - drug effects Biological and medical sciences Brain - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors excitatory amino acids Fundamental and applied biological sciences. Psychology glutamate receptors Kinetics N-methyl- d-aspartate receptors Rats Rats, Inbred Strains Valine - analogs & derivatives Valine - metabolism Vertebrates: nervous system and sense organs
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