JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

Erythropoietin (EPO) regulates the proliferation and differentiation of erythroid cells through interaction with its receptor (EPOR). Although EPOR is a member of the cytokine receptor superfamily and lacks a kinase domain, EPO induces tyrosine phosphorylation, which is correlated with gene transcri...

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Veröffentlicht in:	Cell 1993-07, Vol.74 (2), p.227-236
Hauptverfasser:	Witthuhn, Bruce A., Quelle, Frederick W., Silvennoinen, Olli, Yi, Taolin, Tang, Bo, Miura, Osamu, Ihle, James N.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell Division Cell physiology Enzyme Activation Erythropoietin - metabolism Fundamental and applied biological sciences. Psychology Janus Kinase 2 Mammalia Mice Models, Biological Molecular and cellular biology Phosphorylation Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins Receptors, Erythropoietin - genetics Receptors, Erythropoietin - metabolism Recombinant Fusion Proteins - metabolism Signal Transduction Transfection Tyrosine - metabolism
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