Choroidal neovascularization can digest Bruch's membrane: a prior break is not essential
A novel form of retinal phototoxicity has facilitated investigation of the effect of retinal pigment epithelial (RPE) damage on the choriocapillaris of the rat. In response to isolated RPE injury, the choriocapillaris buds, digests the endothelial basement membrane, and projects pseudopodia that ero...
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| Veröffentlicht in: | Ophthalmology (Rochester, Minn.) Minn.), 1984-12, Vol.91 (12), p.1603-1608 |
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| container_issue | 12 |
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| container_title | Ophthalmology (Rochester, Minn.) |
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| creator | HERIOT, W. J HENKIND, P BELLHORN, R. W BURNS, M. S |
| description | A novel form of retinal phototoxicity has facilitated investigation of the effect of retinal pigment epithelial (RPE) damage on the choriocapillaris of the rat. In response to isolated RPE injury, the choriocapillaris buds, digests the endothelial basement membrane, and projects pseudopodia that erode Bruch's membrane. The development of subretinal neovascularization in one of the rats demonstrates that breaks in Bruch's membrane may result from this lytic process and that neither degeneration of Bruch's membrane nor a preexisting break is essential for subretinal neovascularization to occur. |
| doi_str_mv | 10.1016/S0161-6420(84)34112-4 |
| format | Article |
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The development of subretinal neovascularization in one of the rats demonstrates that breaks in Bruch's membrane may result from this lytic process and that neither degeneration of Bruch's membrane nor a preexisting break is essential for subretinal neovascularization to occur.</description><identifier>ISSN: 0161-6420</identifier><identifier>EISSN: 1549-4713</identifier><identifier>DOI: 10.1016/S0161-6420(84)34112-4</identifier><identifier>PMID: 6084226</identifier><identifier>CODEN: OPHTDG</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Animals ; Basement Membrane - enzymology ; Basement Membrane - ultrastructure ; Biological and medical sciences ; Choroid - blood supply ; Choroid - enzymology ; Disease Models, Animal ; Macular Degeneration - enzymology ; Macular Degeneration - pathology ; Medical sciences ; Neovascularization, Pathologic - enzymology ; Neovascularization, Pathologic - pathology ; Ophthalmology ; Peptide Hydrolases - metabolism ; Pigment Epithelium of Eye - ultrastructure ; Rats ; Retinal Perforations - pathology ; Retinopathies</subject><ispartof>Ophthalmology (Rochester, Minn.), 1984-12, Vol.91 (12), p.1603-1608</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9068123$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6084226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HERIOT, W. 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| fulltext | fulltext |
| identifier | ISSN: 0161-6420 |
| ispartof | Ophthalmology (Rochester, Minn.), 1984-12, Vol.91 (12), p.1603-1608 |
| issn | 0161-6420 1549-4713 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Basement Membrane - enzymology Basement Membrane - ultrastructure Biological and medical sciences Choroid - blood supply Choroid - enzymology Disease Models, Animal Macular Degeneration - enzymology Macular Degeneration - pathology Medical sciences Neovascularization, Pathologic - enzymology Neovascularization, Pathologic - pathology Ophthalmology Peptide Hydrolases - metabolism Pigment Epithelium of Eye - ultrastructure Rats Retinal Perforations - pathology Retinopathies |
| title | Choroidal neovascularization can digest Bruch's membrane: a prior break is not essential |
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