Functional properties of carbohydrate-depleted tissue plasminogen activator

In order to evaluate the importance of the carbohydrate moiety of human tissue plasminogen activator (TPA), human melanoma (Bowes) cells were treated with a glycosylation inhibitor, tunicamycin (TM), and cellular fractions were assayed for fibrinolytic activity. Where glycosylation was inhibited by...

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Veröffentlicht in:	Biochemistry (Easton) 1984-12, Vol.23 (25), p.6191-6195
Hauptverfasser:	Little, Sheila P, Bang, Nils U, Harms, Cathy S, Marks, Carole A, Mattler, Lawrence E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosaminidase - metabolism Biological and medical sciences Blood coagulation. Blood cells Carbohydrates - physiology Cell Line Chromatography, Affinity Enzyme Activation Fibrin - metabolism Fundamental and applied biological sciences. Psychology General aspects, investigation methods, hemostasis, fibrinolysis Glucosamine - metabolism Humans Kinetics Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase Melanoma - metabolism Molecular and cellular biology Plasminogen - metabolism Plasminogen Activators - physiology Tunicamycin - pharmacology
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