Lupus miliaris disseminatus faciei-pathologic study of early, fully developed, and late lesions
Lupus miliaris disseminatus faciei is a chronic inflammatory disorder, which affects adults of both sexes. This study included 25 patients with lupus miliaris disseminatus faciei. Three biopsies, representing early, fully developed, and late lesions, were taken from each patient. Histopathologic exa...
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| Veröffentlicht in: | International journal of dermatology 1993-07, Vol.32 (7), p.508-511 |
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| creator | el Darouti, M Zaher, H |
| description | Lupus miliaris disseminatus faciei is a chronic inflammatory disorder, which affects adults of both sexes.
This study included 25 patients with lupus miliaris disseminatus faciei. Three biopsies, representing early, fully developed, and late lesions, were taken from each patient.
Histopathologic examination of the different lesions revealed that in early lesions, all of them showed superficial perivascular and periappendigeal cellular infiltrate composed mostly of lymphocytes and few histiocytes with occasional neutrophils. The fully developed lesions showed a sarcoidal granuloma only (40%), sarcoidal granuloma with abscess (24%), sarcoidal granuloma around areas of caseation necrosis (20%), and a mixture of sarcoidal and tuberculoid granulomas (16%).
All the late lesions showed extensive fibrosis especially in the perifollicular areas. Scattered lymphocytes, histiocytes and neutrophils were present within the fibrotic areas. A possible explanation of the pathogenesis is discussed. |
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This study included 25 patients with lupus miliaris disseminatus faciei. Three biopsies, representing early, fully developed, and late lesions, were taken from each patient.
Histopathologic examination of the different lesions revealed that in early lesions, all of them showed superficial perivascular and periappendigeal cellular infiltrate composed mostly of lymphocytes and few histiocytes with occasional neutrophils. The fully developed lesions showed a sarcoidal granuloma only (40%), sarcoidal granuloma with abscess (24%), sarcoidal granuloma around areas of caseation necrosis (20%), and a mixture of sarcoidal and tuberculoid granulomas (16%).
All the late lesions showed extensive fibrosis especially in the perifollicular areas. Scattered lymphocytes, histiocytes and neutrophils were present within the fibrotic areas. A possible explanation of the pathogenesis is discussed.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>PMID: 8340186</identifier><identifier>CODEN: IJDEBB</identifier><language>eng</language><publisher>Oxford: Blackwell Science</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Chronic Disease ; Dermatology ; Facial Dermatoses - pathology ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Skin - pathology ; Skin involvement in other diseases. Miscellaneous. General aspects ; Tropical medicine</subject><ispartof>International journal of dermatology, 1993-07, Vol.32 (7), p.508-511</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4796225$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8340186$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>el Darouti, M</creatorcontrib><creatorcontrib>Zaher, H</creatorcontrib><title>Lupus miliaris disseminatus faciei-pathologic study of early, fully developed, and late lesions</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Lupus miliaris disseminatus faciei is a chronic inflammatory disorder, which affects adults of both sexes.
This study included 25 patients with lupus miliaris disseminatus faciei. Three biopsies, representing early, fully developed, and late lesions, were taken from each patient.
Histopathologic examination of the different lesions revealed that in early lesions, all of them showed superficial perivascular and periappendigeal cellular infiltrate composed mostly of lymphocytes and few histiocytes with occasional neutrophils. The fully developed lesions showed a sarcoidal granuloma only (40%), sarcoidal granuloma with abscess (24%), sarcoidal granuloma around areas of caseation necrosis (20%), and a mixture of sarcoidal and tuberculoid granulomas (16%).
All the late lesions showed extensive fibrosis especially in the perifollicular areas. Scattered lymphocytes, histiocytes and neutrophils were present within the fibrotic areas. A possible explanation of the pathogenesis is discussed.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Dermatology</subject><subject>Facial Dermatoses - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Skin - pathology</subject><subject>Skin involvement in other diseases. Miscellaneous. General aspects</subject><subject>Tropical medicine</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LxDAQhoMo67r6E4QcxNMW8t30KOIXLHjZe5lNJhpJP2xaof_egkV4YZh5HubwnpEtl0YXykhxTraMcV5UTFeX5Crnr2WVgqsN2VipGLdmS-rD1E-ZNjFFGGKmPuaMTWxhXK4BXMRY9DB-dqn7iI7mcfIz7QJFGNK8p2FKaaYefzB1Pfo9hdbTBCPShDl2bb4mFwFSxpt17sjx-en4-Foc3l_eHh8ORW-FKUqvhTQyIKoTPwGwSks0KEAwY23pvA0iGKFKw51WjhvFhWM8WClQccbkjtz_ve2H7nvCPNZNzA5Tgha7Kdeltku0WsTbVZxODfq6H2IDw1yvhSz8buWQHaQwQOti_tdUWRkhtPwFmhtqLA</recordid><startdate>199307</startdate><enddate>199307</enddate><creator>el Darouti, M</creator><creator>Zaher, H</creator><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199307</creationdate><title>Lupus miliaris disseminatus faciei-pathologic study of early, fully developed, and late lesions</title><author>el Darouti, M ; Zaher, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p826-7d52363fee4b1baa0953e6e2a206887cd8f2f624761c54c16412c01f832e41003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Dermatology</topic><topic>Facial Dermatoses - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Skin - pathology</topic><topic>Skin involvement in other diseases. Miscellaneous. General aspects</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>el Darouti, M</creatorcontrib><creatorcontrib>Zaher, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>el Darouti, M</au><au>Zaher, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lupus miliaris disseminatus faciei-pathologic study of early, fully developed, and late lesions</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>1993-07</date><risdate>1993</risdate><volume>32</volume><issue>7</issue><spage>508</spage><epage>511</epage><pages>508-511</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><coden>IJDEBB</coden><abstract>Lupus miliaris disseminatus faciei is a chronic inflammatory disorder, which affects adults of both sexes.
This study included 25 patients with lupus miliaris disseminatus faciei. Three biopsies, representing early, fully developed, and late lesions, were taken from each patient.
Histopathologic examination of the different lesions revealed that in early lesions, all of them showed superficial perivascular and periappendigeal cellular infiltrate composed mostly of lymphocytes and few histiocytes with occasional neutrophils. The fully developed lesions showed a sarcoidal granuloma only (40%), sarcoidal granuloma with abscess (24%), sarcoidal granuloma around areas of caseation necrosis (20%), and a mixture of sarcoidal and tuberculoid granulomas (16%).
All the late lesions showed extensive fibrosis especially in the perifollicular areas. Scattered lymphocytes, histiocytes and neutrophils were present within the fibrotic areas. A possible explanation of the pathogenesis is discussed.</abstract><cop>Oxford</cop><pub>Blackwell Science</pub><pmid>8340186</pmid><tpages>4</tpages></addata></record> |
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| ispartof | International journal of dermatology, 1993-07, Vol.32 (7), p.508-511 |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adolescent Adult Biological and medical sciences Chronic Disease Dermatology Facial Dermatoses - pathology Female Humans Male Medical sciences Middle Aged Skin - pathology Skin involvement in other diseases. Miscellaneous. General aspects Tropical medicine |
| title | Lupus miliaris disseminatus faciei-pathologic study of early, fully developed, and late lesions |
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