Hemodilution with oxyhemoglobin. Mechanism of oxygen delivery and its superaugmentation with a nitric oxide donor (sodium nitroprusside)

Hemodilution (HD) with oxyhemoglobin colloid (oxyHb) provides a greater arterial oxygen content (CaO2) than HD with conventional colloids; however, oxygen delivery (DO2) is essentially the same, because, in contrast to conventional HD, cardiac output (CO) is not augmented. This study seeks to elucid...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 1993-07, Vol.79 (1), p.60-72
Hauptverfasser:	Rooney, M W, Hirsch, L J, Mathru, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiac Output - drug effects Colloids - pharmacology Dogs Endothelium, Vascular - metabolism Heart - drug effects Heart - physiology Hemodilution - methods Male Methemoglobin - pharmacology Nitric Oxide - pharmacology Nitroprusside - pharmacology Oxygen - administration & dosage Oxygen - blood Oxyhemoglobins - pharmacology Serum Albumin - pharmacology
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