Magnetic microcapsules for targeted delivery of anticancer drugs
To achieve targeted distribution of anticancer drugs with sustained activity, ferromagnetic ethylcellulose microcapsules containing an anticancer drug, mitomycin C (FM-MMC-mc), were prepared by a method based on phase separation principles. Two prototypes of FM-MMC-mc were made: one with the drug as...
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| Veröffentlicht in: | Applied biochemistry and biotechnology 1984-01, Vol.10 (1-3), p.199-211 |
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| container_title | Applied biochemistry and biotechnology |
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| creator | KATO, T NEMOTO, R MORI, H ABE, R UNNO, K GOTO, A MUROTA, H HARADA, M HOMMA, M |
| description | To achieve targeted distribution of anticancer drugs with sustained activity, ferromagnetic ethylcellulose microcapsules containing an anticancer drug, mitomycin C (FM-MMC-mc), were prepared by a method based on phase separation principles. Two prototypes of FM-MMC-mc were made: one with the drug as the core and zinc ferrite on its capsular surface (outer type); the other with both the drug and zinc ferrite as the core (inner type). Both preparations provided a sustained-release property and a sensitive response to conventional magnetic force, although certain differences in the release rate of drug, magnetic responsiveness, and particle size were found between the two dosage forms. Animal studies showed that the magnetic microcapsules could be magnetically controlled in the artery and urinary bladder. VX2 tumors in the rabbit hind limb and urinary bladder were successfully treated with magnetic control of FM-MMC-mc. Pharmacokinetic study revealed that the targeting of the microcapsules markedly enhanced the drug absorption into the surrounding tissues for a prolonged period of time. The results indicate the feasibility and effectiveness of the magnetic microcapsules as a targeted drug delivery system. |
| doi_str_mv | 10.1007/BF02783752 |
| format | Article |
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Two prototypes of FM-MMC-mc were made: one with the drug as the core and zinc ferrite on its capsular surface (outer type); the other with both the drug and zinc ferrite as the core (inner type). Both preparations provided a sustained-release property and a sensitive response to conventional magnetic force, although certain differences in the release rate of drug, magnetic responsiveness, and particle size were found between the two dosage forms. Animal studies showed that the magnetic microcapsules could be magnetically controlled in the artery and urinary bladder. VX2 tumors in the rabbit hind limb and urinary bladder were successfully treated with magnetic control of FM-MMC-mc. Pharmacokinetic study revealed that the targeting of the microcapsules markedly enhanced the drug absorption into the surrounding tissues for a prolonged period of time. The results indicate the feasibility and effectiveness of the magnetic microcapsules as a targeted drug delivery system.</description><identifier>ISSN: 0273-2289</identifier><identifier>EISSN: 1559-0291</identifier><identifier>DOI: 10.1007/BF02783752</identifier><identifier>PMID: 6441520</identifier><identifier>CODEN: ABIBDL</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Animals ; Antineoplastic Agents - administration & dosage ; Aorta - metabolism ; Biological and medical sciences ; Capsules ; Cellulose - analogs & derivatives ; Dogs ; Ferric Compounds ; General pharmacology ; Magnetics ; Medical sciences ; Mitomycin ; Mitomycins - administration & dosage ; Mitomycins - metabolism ; Neoplasms, Experimental - drug therapy ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Rabbits ; Urinary Bladder - metabolism ; Urinary Bladder Neoplasms - drug therapy</subject><ispartof>Applied biochemistry and biotechnology, 1984-01, Vol.10 (1-3), p.199-211</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-31150eadecfebd1e8ff20408785b48d022d581c03bd6a2c820f34691cd20af163</citedby><cites>FETCH-LOGICAL-c311t-31150eadecfebd1e8ff20408785b48d022d581c03bd6a2c820f34691cd20af163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9291850$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6441520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KATO, T</creatorcontrib><creatorcontrib>NEMOTO, R</creatorcontrib><creatorcontrib>MORI, H</creatorcontrib><creatorcontrib>ABE, R</creatorcontrib><creatorcontrib>UNNO, K</creatorcontrib><creatorcontrib>GOTO, A</creatorcontrib><creatorcontrib>MUROTA, H</creatorcontrib><creatorcontrib>HARADA, M</creatorcontrib><creatorcontrib>HOMMA, M</creatorcontrib><title>Magnetic microcapsules for targeted delivery of anticancer drugs</title><title>Applied biochemistry and biotechnology</title><addtitle>Appl Biochem Biotechnol</addtitle><description>To achieve targeted distribution of anticancer drugs with sustained activity, ferromagnetic ethylcellulose microcapsules containing an anticancer drug, mitomycin C (FM-MMC-mc), were prepared by a method based on phase separation principles. Two prototypes of FM-MMC-mc were made: one with the drug as the core and zinc ferrite on its capsular surface (outer type); the other with both the drug and zinc ferrite as the core (inner type). Both preparations provided a sustained-release property and a sensitive response to conventional magnetic force, although certain differences in the release rate of drug, magnetic responsiveness, and particle size were found between the two dosage forms. Animal studies showed that the magnetic microcapsules could be magnetically controlled in the artery and urinary bladder. VX2 tumors in the rabbit hind limb and urinary bladder were successfully treated with magnetic control of FM-MMC-mc. Pharmacokinetic study revealed that the targeting of the microcapsules markedly enhanced the drug absorption into the surrounding tissues for a prolonged period of time. The results indicate the feasibility and effectiveness of the magnetic microcapsules as a targeted drug delivery system.</description><subject>Animals</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Aorta - metabolism</subject><subject>Biological and medical sciences</subject><subject>Capsules</subject><subject>Cellulose - analogs & derivatives</subject><subject>Dogs</subject><subject>Ferric Compounds</subject><subject>General pharmacology</subject><subject>Magnetics</subject><subject>Medical sciences</subject><subject>Mitomycin</subject><subject>Mitomycins - administration & dosage</subject><subject>Mitomycins - metabolism</subject><subject>Neoplasms, Experimental - drug therapy</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Rabbits</subject><subject>Urinary Bladder - metabolism</subject><subject>Urinary Bladder Neoplasms - drug therapy</subject><issn>0273-2289</issn><issn>1559-0291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LxDAQhoMo67p68S70IB6E6iRtmvSmLq4KK170XNJkUir9WJNW2H9vli3rZQbmfXhhHkIuKdxRAHH_tAImZCI4OyJzynkeA8vpMZmHcxIzJvNTcub9NwBlkosZmWVpSjmDOXl4V1WHQ62jttau12rjxwZ9ZHsXDcpVOKCJDDb1L7pt1NtIdQFWnUYXGTdW_pycWNV4vJj2gnytnj-Xr_H64-Vt-biOdULpEIfBAZVBbbE0FKW1DFKQQvIylQYYM1xSDUlpMsW0ZGCTNMupNgyUpVmyIDf73o3rf0b0Q9HWXmPTqA770ReCS0GF3IG3ezC8471DW2xc3Sq3LSgUO13Fv64AX02tY9miOaCTn5BfT7nyWjXWhc9rf8DyoFlySP4AxFVw_g</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>KATO, T</creator><creator>NEMOTO, R</creator><creator>MORI, H</creator><creator>ABE, R</creator><creator>UNNO, K</creator><creator>GOTO, A</creator><creator>MUROTA, H</creator><creator>HARADA, M</creator><creator>HOMMA, M</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>Magnetic microcapsules for targeted delivery of anticancer drugs</title><author>KATO, T ; NEMOTO, R ; MORI, H ; ABE, R ; UNNO, K ; GOTO, A ; MUROTA, H ; HARADA, M ; HOMMA, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-31150eadecfebd1e8ff20408785b48d022d581c03bd6a2c820f34691cd20af163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Aorta - metabolism</topic><topic>Biological and medical sciences</topic><topic>Capsules</topic><topic>Cellulose - analogs & derivatives</topic><topic>Dogs</topic><topic>Ferric Compounds</topic><topic>General pharmacology</topic><topic>Magnetics</topic><topic>Medical sciences</topic><topic>Mitomycin</topic><topic>Mitomycins - administration & dosage</topic><topic>Mitomycins - metabolism</topic><topic>Neoplasms, Experimental - drug therapy</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. 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Two prototypes of FM-MMC-mc were made: one with the drug as the core and zinc ferrite on its capsular surface (outer type); the other with both the drug and zinc ferrite as the core (inner type). Both preparations provided a sustained-release property and a sensitive response to conventional magnetic force, although certain differences in the release rate of drug, magnetic responsiveness, and particle size were found between the two dosage forms. Animal studies showed that the magnetic microcapsules could be magnetically controlled in the artery and urinary bladder. VX2 tumors in the rabbit hind limb and urinary bladder were successfully treated with magnetic control of FM-MMC-mc. Pharmacokinetic study revealed that the targeting of the microcapsules markedly enhanced the drug absorption into the surrounding tissues for a prolonged period of time. The results indicate the feasibility and effectiveness of the magnetic microcapsules as a targeted drug delivery system.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>6441520</pmid><doi>10.1007/BF02783752</doi><tpages>13</tpages></addata></record> |
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| identifier | ISSN: 0273-2289 |
| ispartof | Applied biochemistry and biotechnology, 1984-01, Vol.10 (1-3), p.199-211 |
| issn | 0273-2289 1559-0291 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Antineoplastic Agents - administration & dosage Aorta - metabolism Biological and medical sciences Capsules Cellulose - analogs & derivatives Dogs Ferric Compounds General pharmacology Magnetics Medical sciences Mitomycin Mitomycins - administration & dosage Mitomycins - metabolism Neoplasms, Experimental - drug therapy Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rabbits Urinary Bladder - metabolism Urinary Bladder Neoplasms - drug therapy |
| title | Magnetic microcapsules for targeted delivery of anticancer drugs |
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