Percutaneous Absorption of Butylparaben in Vitro. II. Effects of Micellar Trapping of the Drug and Percutaneous Absorption of Nonionic Surfactants
The effect of surfactants on the percutaneous absorption of butylparaben from micellar solution was studied. Percutaneous absorption of butylparaben from aqueous solution containing the critical micellar concentration (cmc) of a surfactant was measured in order to determine the contribution of the f...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1984/09/25, Vol.32(9), pp.3739-3743 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | KOMATSU, HIDEO |
| description | The effect of surfactants on the percutaneous absorption of butylparaben from micellar solution was studied. Percutaneous absorption of butylparaben from aqueous solution containing the critical micellar concentration (cmc) of a surfactant was measured in order to determine the contribution of the free butylparaben. Percutaneous absorption of polysorbate 80 and octaethyleneglycol dodecyl ether was also measured in order to evaluate the effect of absorption of micelles, if any. The results indicated that the surfactants were scarcely absorbed, but the free concentration of butylparaben could not account for the total drug absorption from micellar solution. However, the amount of surfactant absorbed increased with increase in the surfactant concentration above the cmc, indicating that surfactant molecules in micelles could be absorbed. This suggests that some of the micelles were adsorbed and/or dissociated on the skin surface, so that the effective concentration of surfactant as well as that of butylparaben for percutaneous absorption would be increased. |
| doi_str_mv | 10.1248/cpb.32.3739 |
| format | Article |
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The results indicated that the surfactants were scarcely absorbed, but the free concentration of butylparaben could not account for the total drug absorption from micellar solution. However, the amount of surfactant absorbed increased with increase in the surfactant concentration above the cmc, indicating that surfactant molecules in micelles could be absorbed. This suggests that some of the micelles were adsorbed and/or dissociated on the skin surface, so that the effective concentration of surfactant as well as that of butylparaben for percutaneous absorption would be increased.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.32.3739</identifier><identifier>PMID: 6525663</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Biological and medical sciences ; General pharmacology ; Guinea Pigs ; In Vitro Techniques ; Male ; Medical sciences ; micelle ; Micelles ; Parabens - metabolism ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. 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However, the amount of surfactant absorbed increased with increase in the surfactant concentration above the cmc, indicating that surfactant molecules in micelles could be absorbed. This suggests that some of the micelles were adsorbed and/or dissociated on the skin surface, so that the effective concentration of surfactant as well as that of butylparaben for percutaneous absorption would be increased.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>General pharmacology</subject><subject>Guinea Pigs</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Medical sciences</subject><subject>micelle</subject><subject>Micelles</subject><subject>Parabens - metabolism</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Skin Absorption - drug effects</subject><subject>Surface-Active Agents - metabolism</subject><subject>Surface-Active Agents - pharmacology</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv3CAUhVHVKp2kXXVdiUXVTWUXjDFmmebRjpQ-pKbdWhcMEyIPdgAv8jf6i4sz1nTXDaB7Pu7hchB6Q0lJq7r9qCdVsqpkgslnaENZLQpeVew52hBCZFGxhr1EpzHeE1JxItgJOml4xZuGbdCfHyboOYE34xzxuYpjmJIbPR4t_jSnx2GCAMp47Dz-7VIYS7zdlvjKWqNTXKivTpthgIBvA0yT87ulmO4MvgzzDoPv8X8svo0-n5zGP-dgQWcoxVfohYUhmtfrfoZ-XV_dXnwpbr5_3l6c3xQ6TycLTkWrlDSiZcB7SXsuWskUb3rOhaWqN42ynNUKhFWUE2W0Vq2pKRENmJ6xM_T-0HcK48NsYur2Lj7N8vTSTvBW5Hs0gx8OoA5jjMHYbgpuD-Gxo6RbEuhyAh2ruiWBTL9d285qb_oju3551t-tOkQNgw3gtYtHTBJOOa0zdnnA7mOCnTnqEJLTg1ksqeTtYivXJbv_k-8gdMazv3U5qG4</recordid><startdate>1984</startdate><enddate>1984</enddate><creator>KOMATSU, HIDEO</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1984</creationdate><title>Percutaneous Absorption of Butylparaben in Vitro. 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Drug treatments</topic><topic>Skin Absorption - drug effects</topic><topic>Surface-Active Agents - metabolism</topic><topic>Surface-Active Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOMATSU, HIDEO</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOMATSU, HIDEO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Percutaneous Absorption of Butylparaben in Vitro. II. Effects of Micellar Trapping of the Drug and Percutaneous Absorption of Nonionic Surfactants</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1984</date><risdate>1984</risdate><volume>32</volume><issue>9</issue><spage>3739</spage><epage>3743</epage><pages>3739-3743</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>The effect of surfactants on the percutaneous absorption of butylparaben from micellar solution was studied. Percutaneous absorption of butylparaben from aqueous solution containing the critical micellar concentration (cmc) of a surfactant was measured in order to determine the contribution of the free butylparaben. Percutaneous absorption of polysorbate 80 and octaethyleneglycol dodecyl ether was also measured in order to evaluate the effect of absorption of micelles, if any. The results indicated that the surfactants were scarcely absorbed, but the free concentration of butylparaben could not account for the total drug absorption from micellar solution. However, the amount of surfactant absorbed increased with increase in the surfactant concentration above the cmc, indicating that surfactant molecules in micelles could be absorbed. This suggests that some of the micelles were adsorbed and/or dissociated on the skin surface, so that the effective concentration of surfactant as well as that of butylparaben for percutaneous absorption would be increased.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>6525663</pmid><doi>10.1248/cpb.32.3739</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chemical and Pharmaceutical Bulletin, 1984/09/25, Vol.32(9), pp.3739-3743 |
| issn | 0009-2363 1347-5223 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Biological and medical sciences General pharmacology Guinea Pigs In Vitro Techniques Male Medical sciences micelle Micelles Parabens - metabolism Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Skin Absorption - drug effects Surface-Active Agents - metabolism Surface-Active Agents - pharmacology |
| title | Percutaneous Absorption of Butylparaben in Vitro. II. Effects of Micellar Trapping of the Drug and Percutaneous Absorption of Nonionic Surfactants |
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