Simultaneous demonstration of the Philadelphia chromosome in T, B, and myeloid cells

A patient presented with lymphoblastic lymphoma in lymph‐nodes and chronic myeloge‐nous leukemia (CML) in marrow and peripheral blood. All marrow and unstimulated peripheral blood cells contained the Philadelphia chromosome{t(9:22)}. Lymphoma cells were analyzed by flow cytometry and were identified...

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Veröffentlicht in:	American journal of hematology 1993-09, Vol.44 (1), p.48-52
Hauptverfasser:	Mackinney, Archie A., Clark, Steven S., Borcherding, Wayne, Fizzotti, Marco, Hong, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - analysis Antigens, CD34 Antigens, CD7 Antigens, Differentiation, T-Lymphocyte - analysis B-Lymphocytes - pathology B-Lymphocytes - ultrastructure Biological and medical sciences Biopsy Bone Marrow - pathology Bone Marrow - ultrastructure CD2 Antigens CD5 Antigens cytogenetics DNA, Neoplasm - genetics Flow Cytometry Gene Rearrangement Hematologic and hematopoietic diseases Humans Immunoblotting Killer Cells, Natural - pathology Killer Cells, Natural - ultrastructure Leukemia, Myelogenous, Chronic, BCR-ABL Positive - complications Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, T-Cell - complications Lymphoma, T-Cell - pathology Male Medical sciences Middle Aged Philadelphia Chromosome Protein-Tyrosine Kinases Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-bcr Receptors, Immunologic - analysis stem cell Stem Cells - immunology Stem Cells - pathology T cell lymphoma T-Lymphocytes - immunology T-Lymphocytes - pathology T-Lymphocytes - ultrastructure Translocation, Genetic Tumor Cells, Cultured - pathology
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