The effect of osmotic gradients on the outward potassium current in dialyzed neurons of Helix pomatia
1. The effect of outward and inward water flows through the membrane on outward potassium currents of dialyzed Helix pomatia neurons was studied. 2. An outward water flow increased the peak and sustained outward potassium currents and accelerated the kinetics of their activation. An inward water flo...
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| Veröffentlicht in: | Cellular and molecular neurobiology 1993-04, Vol.13 (2), p.183-190 |
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| container_end_page | 190 |
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| container_title | Cellular and molecular neurobiology |
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| creator | SULEYMANIAN, M. A AYRAPETYAN, S. N ARAKELYAN, V. B AYRAPETYAN, V. Y |
| description | 1. The effect of outward and inward water flows through the membrane on outward potassium currents of dialyzed Helix pomatia neurons was studied. 2. An outward water flow increased the peak and sustained outward potassium currents and accelerated the kinetics of their activation. An inward water flow had quite opposite effects--it decreased the peak and sustained potassium currents and delayed the kinetics of their activation. 3. The analysis of the effect of water flow on the conductance of potassium channels showed that an outward water flow increased both the potassium conductance at a given potential (gk) and the maximum potassium conductance (gkmax). An inward water flow again had the opposite effect--it decreased the potassium conductance at given potential and the maximum potassium conductance. 4. Neither an outward nor an inward water flow significantly affected the fraction of open potassium channels at a given potential [n infinity(V)]. 5. These data suggest that in dialyzed neurons the changes of outward potassium current during water flow through the membrane are due mainly to the changes in single-channel conductance and the time constant of current activation. |
| doi_str_mv | 10.1007/BF00735374 |
| format | Article |
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A ; AYRAPETYAN, S. N ; ARAKELYAN, V. B ; AYRAPETYAN, V. Y</creator><creatorcontrib>SULEYMANIAN, M. A ; AYRAPETYAN, S. N ; ARAKELYAN, V. B ; AYRAPETYAN, V. Y</creatorcontrib><description>1. The effect of outward and inward water flows through the membrane on outward potassium currents of dialyzed Helix pomatia neurons was studied. 2. An outward water flow increased the peak and sustained outward potassium currents and accelerated the kinetics of their activation. An inward water flow had quite opposite effects--it decreased the peak and sustained potassium currents and delayed the kinetics of their activation. 3. The analysis of the effect of water flow on the conductance of potassium channels showed that an outward water flow increased both the potassium conductance at a given potential (gk) and the maximum potassium conductance (gkmax). An inward water flow again had the opposite effect--it decreased the potassium conductance at given potential and the maximum potassium conductance. 4. Neither an outward nor an inward water flow significantly affected the fraction of open potassium channels at a given potential [n infinity(V)]. 5. These data suggest that in dialyzed neurons the changes of outward potassium current during water flow through the membrane are due mainly to the changes in single-channel conductance and the time constant of current activation.</description><identifier>ISSN: 0272-4340</identifier><identifier>EISSN: 1573-6830</identifier><identifier>DOI: 10.1007/BF00735374</identifier><identifier>PMID: 8348592</identifier><identifier>CODEN: CMNEDI</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Animals ; Biological and medical sciences ; Cell Membrane - drug effects ; Cell Membrane - metabolism ; Cell physiology ; Dialysis ; Freshwater ; Fundamental and applied biological sciences. Psychology ; Helix pomatia ; Helix, Snails ; Hypertonic Solutions - pharmacology ; Hypotonic Solutions - pharmacology ; Isotonic Solutions - pharmacology ; Membrane and intracellular transports ; Membrane Potentials - drug effects ; Molecular and cellular biology ; Neurons - drug effects ; Neurons - metabolism ; Osmotic Pressure ; Potassium - metabolism ; Water - metabolism</subject><ispartof>Cellular and molecular neurobiology, 1993-04, Vol.13 (2), p.183-190</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4752944$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8348592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SULEYMANIAN, M. A</creatorcontrib><creatorcontrib>AYRAPETYAN, S. N</creatorcontrib><creatorcontrib>ARAKELYAN, V. B</creatorcontrib><creatorcontrib>AYRAPETYAN, V. Y</creatorcontrib><title>The effect of osmotic gradients on the outward potassium current in dialyzed neurons of Helix pomatia</title><title>Cellular and molecular neurobiology</title><addtitle>Cell Mol Neurobiol</addtitle><description>1. The effect of outward and inward water flows through the membrane on outward potassium currents of dialyzed Helix pomatia neurons was studied. 2. An outward water flow increased the peak and sustained outward potassium currents and accelerated the kinetics of their activation. An inward water flow had quite opposite effects--it decreased the peak and sustained potassium currents and delayed the kinetics of their activation. 3. The analysis of the effect of water flow on the conductance of potassium channels showed that an outward water flow increased both the potassium conductance at a given potential (gk) and the maximum potassium conductance (gkmax). An inward water flow again had the opposite effect--it decreased the potassium conductance at given potential and the maximum potassium conductance. 4. Neither an outward nor an inward water flow significantly affected the fraction of open potassium channels at a given potential [n infinity(V)]. 5. These data suggest that in dialyzed neurons the changes of outward potassium current during water flow through the membrane are due mainly to the changes in single-channel conductance and the time constant of current activation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Membrane - drug effects</subject><subject>Cell Membrane - metabolism</subject><subject>Cell physiology</subject><subject>Dialysis</subject><subject>Freshwater</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Helix pomatia</subject><subject>Helix, Snails</subject><subject>Hypertonic Solutions - pharmacology</subject><subject>Hypotonic Solutions - pharmacology</subject><subject>Isotonic Solutions - pharmacology</subject><subject>Membrane and intracellular transports</subject><subject>Membrane Potentials - drug effects</subject><subject>Molecular and cellular biology</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Osmotic Pressure</subject><subject>Potassium - metabolism</subject><subject>Water - metabolism</subject><issn>0272-4340</issn><issn>1573-6830</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0DtLBDEUBeAgiq6rjb2QQuxG70xek1IXXyDYaL1kkxuNzEzWJIOPX--Ii63NvcX5OMUh5KiGsxpAnV9eT5cJpvgWmdVCsUq2DLbJDBrVVJxx2CP7Ob8CgAYQu2S3ZbwVupkRfHxBit6jLTR6GnMfS7D0ORkXcCiZxoGWicSxvJvk6DoWk3MYe2rHlCZBw0BdMN3nFzo64JjikH-abrELHxPvTQnmgOx402U83Pw5ebq-elzcVvcPN3eLi_tq3UhZqhpkY1FoJTU45oWwWgjjFKsNeifA-RXnCNy3WlrFVyveGAeyrjVXqKxlc3L627tO8W3EXJZ9yBa7zgwYx7xUolUgNPsX1lIKyadR5-R4A8dVj265TqE36XO5GXDKTza5ydZ0PpnBhvzHuBKN5px9Ayrzfr4</recordid><startdate>19930401</startdate><enddate>19930401</enddate><creator>SULEYMANIAN, M. 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Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-1062ce597690d3f55c955ad731aefd50dfb44e04f896c74bb42ad0611947e7cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Membrane - drug effects</topic><topic>Cell Membrane - metabolism</topic><topic>Cell physiology</topic><topic>Dialysis</topic><topic>Freshwater</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Helix pomatia</topic><topic>Helix, Snails</topic><topic>Hypertonic Solutions - pharmacology</topic><topic>Hypotonic Solutions - pharmacology</topic><topic>Isotonic Solutions - pharmacology</topic><topic>Membrane and intracellular transports</topic><topic>Membrane Potentials - drug effects</topic><topic>Molecular and cellular biology</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Osmotic Pressure</topic><topic>Potassium - metabolism</topic><topic>Water - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SULEYMANIAN, M. A</creatorcontrib><creatorcontrib>AYRAPETYAN, S. N</creatorcontrib><creatorcontrib>ARAKELYAN, V. B</creatorcontrib><creatorcontrib>AYRAPETYAN, V. 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Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of osmotic gradients on the outward potassium current in dialyzed neurons of Helix pomatia</atitle><jtitle>Cellular and molecular neurobiology</jtitle><addtitle>Cell Mol Neurobiol</addtitle><date>1993-04-01</date><risdate>1993</risdate><volume>13</volume><issue>2</issue><spage>183</spage><epage>190</epage><pages>183-190</pages><issn>0272-4340</issn><eissn>1573-6830</eissn><coden>CMNEDI</coden><abstract>1. The effect of outward and inward water flows through the membrane on outward potassium currents of dialyzed Helix pomatia neurons was studied. 2. An outward water flow increased the peak and sustained outward potassium currents and accelerated the kinetics of their activation. An inward water flow had quite opposite effects--it decreased the peak and sustained potassium currents and delayed the kinetics of their activation. 3. The analysis of the effect of water flow on the conductance of potassium channels showed that an outward water flow increased both the potassium conductance at a given potential (gk) and the maximum potassium conductance (gkmax). An inward water flow again had the opposite effect--it decreased the potassium conductance at given potential and the maximum potassium conductance. 4. Neither an outward nor an inward water flow significantly affected the fraction of open potassium channels at a given potential [n infinity(V)]. 5. These data suggest that in dialyzed neurons the changes of outward potassium current during water flow through the membrane are due mainly to the changes in single-channel conductance and the time constant of current activation.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>8348592</pmid><doi>10.1007/BF00735374</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Cell Membrane - drug effects Cell Membrane - metabolism Cell physiology Dialysis Freshwater Fundamental and applied biological sciences. Psychology Helix pomatia Helix, Snails Hypertonic Solutions - pharmacology Hypotonic Solutions - pharmacology Isotonic Solutions - pharmacology Membrane and intracellular transports Membrane Potentials - drug effects Molecular and cellular biology Neurons - drug effects Neurons - metabolism Osmotic Pressure Potassium - metabolism Water - metabolism |
| title | The effect of osmotic gradients on the outward potassium current in dialyzed neurons of Helix pomatia |
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