Microbial Transformation of L-696, 474, a Novel Cytochalasin as an Inhibitor of HIV-1 Protease

The microbiological transformation of L-696,474 [1], a novel cytochalasin that is an inhibitor of HIV-1 protease, was investigated using Actinoplanes sp. ATCC 53771. Six hydroxylated metabolites 2-7 of 1 were isolated and purified using reversed-phase hplc. All six metabolites were found to have und...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1993-05, Vol.56 (5), p.755-761
Hauptverfasser:	Chen, Tom S, Doss, George A, Hsu, Annjia, Hsu, Amy, Lingham, Russell B, White, Raymond F, Monaghan, Richard L
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycetales - metabolism AIDS/HIV Amino Acid Sequence Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Biotransformation Cytochalasins - metabolism HIV Protease Inhibitors - metabolism Hydroxylation Isoindoles Medical sciences Molecular Sequence Data Pharmacology. Drug treatments
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!