Amino Acids and Peptides. XVIII. Synthetic Peptides Related to N-Terminal Portion of Fibrin α-Chain and Their Inhibitory Effect on Fibrinogen/Thrombin Clotting

Peptide analogs of the N-terminal portion of fibrin α-chain were prepared and their inhibitory effects on fibrinogen/thrombin clotting were examined. Of the synthetic peptides, H-Gly-Pro-Arg-Pro-Pro-NH2 exhibited the most potent inhibitory effect.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1993/05/15, Vol.41(5), pp.975-977
Hauptverfasser:	KAWASAKI, Koichi, MIYANO, Masanori, HIRASE, Katsuhiko, IWAMOTO, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence anticoagulant Anticoagulants - chemical synthesis Anticoagulants - pharmacology Chemistry Exact sciences and technology Fibrin - analogs & derivatives Fibrin - chemical synthesis Fibrin - pharmacology fibrin α-chain fibrin-related peptide Fibrinogen - antagonists & inhibitors fibrinogen/thrombin clotting Molecular Sequence Data Oligopeptides - chemical synthesis Oligopeptides - chemistry Oligopeptides - pharmacology Organic chemistry peptide synthesis Peptides Preparations and properties Structure-Activity Relationship Thrombin - antagonists & inhibitors
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Beschreibung
Zusammenfassung:	Peptide analogs of the N-terminal portion of fibrin α-chain were prepared and their inhibitory effects on fibrinogen/thrombin clotting were examined. Of the synthetic peptides, H-Gly-Pro-Arg-Pro-Pro-NH2 exhibited the most potent inhibitory effect.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.41.975