Acetylsalicylic Acid, at High Concentrations, Inhibits Vascular Smooth Muscle Cell Proliferation

The growth of human smooth muscle cells in culture is inhibited by acetylsalicylic acid (ASA). In comparison to control, the proliferation of cells treated with 270 mg/L lysinmono(acetylsalicylate)/30 mg/L glycine was inhibited by 50–90% under different culture conditions. Cell numbers per well (con...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1993-06, Vol.21 (6), p.973-976
Hauptverfasser:	Bernhardt, Jens, Rogalla, Konstantin, Lüscher, Thomas F, Bühler, Fritz R, Resink, Thérèse J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - pharmacology Aspirin - analogs & derivatives Aspirin - pharmacology Cell Division - drug effects Cell Survival - drug effects Humans Lysine - analogs & derivatives Lysine - pharmacology Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Phosphatidylinositols - metabolism
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