retinoblastoma-binding protein related to a negative regulator of Ras in yeast
The growth suppression function of the retinoblastoma protein (Rb) is thought to be mediated by Rb binding to cellular proteins p48 is one of the major proteins that binds to a putative functional domain at the carboxy terminus of the Rb protein. Here we report the isolation of a full-length complem...
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| Veröffentlicht in: | Nature (London) 1993-08, Vol.364 (6438), p.648-652 |
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| creator | Qian, Y.W Wang, Y.C.J Hollingsworth, R.E. Jr Jones, D Ling, N Lee, E.Y.H.P |
| description | The growth suppression function of the retinoblastoma protein (Rb) is thought to be mediated by Rb binding to cellular proteins p48 is one of the major proteins that binds to a putative functional domain at the carboxy terminus of the Rb protein. Here we report the isolation of a full-length complementary DNA (RbAp4g) encoding p48. Complex formation between p48 and Rb occurs in vitro and in vivo, and apparently involves direct interaction between the proteins. Like Rb, p48 is a ubiquitously expressed nuclear protein. RbAp4g share sequence homology with MSI1, a negative regulator of the Ras-cyclic AMP pathway in the yeast Saccharomyces cerevisiae. Furthermore, like MSI1, human RbAp48 suppresses the heat-shock sensitivity of the yeast ira1 strains and RAS2(Val19) strains. Interaction with p48 may be one of the mechanisms for suppression of growth mediated by Rb. |
| doi_str_mv | 10.1038/364648a0 |
| format | Article |
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Jr ; Jones, D ; Ling, N ; Lee, E.Y.H.P</creator><creatorcontrib>Qian, Y.W ; Wang, Y.C.J ; Hollingsworth, R.E. Jr ; Jones, D ; Ling, N ; Lee, E.Y.H.P</creatorcontrib><description>The growth suppression function of the retinoblastoma protein (Rb) is thought to be mediated by Rb binding to cellular proteins p48 is one of the major proteins that binds to a putative functional domain at the carboxy terminus of the Rb protein. Here we report the isolation of a full-length complementary DNA (RbAp4g) encoding p48. Complex formation between p48 and Rb occurs in vitro and in vivo, and apparently involves direct interaction between the proteins. Like Rb, p48 is a ubiquitously expressed nuclear protein. RbAp4g share sequence homology with MSI1, a negative regulator of the Ras-cyclic AMP pathway in the yeast Saccharomyces cerevisiae. Furthermore, like MSI1, human RbAp48 suppresses the heat-shock sensitivity of the yeast ira1 strains and RAS2(Val19) strains. Interaction with p48 may be one of the mechanisms for suppression of growth mediated by Rb.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/364648a0</identifier><identifier>PMID: 8350924</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Amino Acid Sequence ; amino acid sequences ; Base Sequence ; binding proteins ; Biological and medical sciences ; Biotechnology ; Carrier Proteins - chemistry ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; cDNA ; Cell cycle, cell proliferation ; Cell physiology ; Cellular biology ; Chromatin Assembly Factor-1 ; cloning ; complex ; DNA ; DNA-Binding Proteins ; Fundamental and applied biological sciences. Psychology ; Fungal Proteins - chemistry ; genes ; Hot Temperature ; Humanities and Social Sciences ; Humans ; letter ; man ; Molecular and cellular biology ; Molecular Sequence Data ; multidisciplinary ; Nuclear Proteins - chemistry ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; nucleotide sequence ; nucleotide sequences ; predictions ; Protein Binding ; protein p48 ; Proteins ; RbAp48 gene ; Recombinant Proteins - metabolism ; Retinoblastoma Protein - metabolism ; retinoblastoma-binding protein ; Retinoblastoma-Binding Protein 4 ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - physiology ; Saccharomyces cerevisiae Proteins ; Science ; Science (multidisciplinary) ; Sequence Homology, Amino Acid ; Tumor Cells, Cultured ; tumor suppressor genes ; Yeast ; Yeasts</subject><ispartof>Nature (London), 1993-08, Vol.364 (6438), p.648-652</ispartof><rights>Springer Nature Limited 1993</rights><rights>1993 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. 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Jr</creatorcontrib><creatorcontrib>Jones, D</creatorcontrib><creatorcontrib>Ling, N</creatorcontrib><creatorcontrib>Lee, E.Y.H.P</creatorcontrib><title>retinoblastoma-binding protein related to a negative regulator of Ras in yeast</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>The growth suppression function of the retinoblastoma protein (Rb) is thought to be mediated by Rb binding to cellular proteins p48 is one of the major proteins that binds to a putative functional domain at the carboxy terminus of the Rb protein. Here we report the isolation of a full-length complementary DNA (RbAp4g) encoding p48. Complex formation between p48 and Rb occurs in vitro and in vivo, and apparently involves direct interaction between the proteins. Like Rb, p48 is a ubiquitously expressed nuclear protein. RbAp4g share sequence homology with MSI1, a negative regulator of the Ras-cyclic AMP pathway in the yeast Saccharomyces cerevisiae. Furthermore, like MSI1, human RbAp48 suppresses the heat-shock sensitivity of the yeast ira1 strains and RAS2(Val19) strains. Interaction with p48 may be one of the mechanisms for suppression of growth mediated by Rb.</description><subject>Amino Acid Sequence</subject><subject>amino acid sequences</subject><subject>Base Sequence</subject><subject>binding proteins</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Carrier Proteins - chemistry</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - metabolism</subject><subject>cDNA</subject><subject>Cell cycle, cell proliferation</subject><subject>Cell physiology</subject><subject>Cellular biology</subject><subject>Chromatin Assembly Factor-1</subject><subject>cloning</subject><subject>complex</subject><subject>DNA</subject><subject>DNA-Binding Proteins</subject><subject>Fundamental and applied biological sciences. 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Like Rb, p48 is a ubiquitously expressed nuclear protein. RbAp4g share sequence homology with MSI1, a negative regulator of the Ras-cyclic AMP pathway in the yeast Saccharomyces cerevisiae. Furthermore, like MSI1, human RbAp48 suppresses the heat-shock sensitivity of the yeast ira1 strains and RAS2(Val19) strains. Interaction with p48 may be one of the mechanisms for suppression of growth mediated by Rb.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>8350924</pmid><doi>10.1038/364648a0</doi><tpages>5</tpages></addata></record> |
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| ispartof | Nature (London), 1993-08, Vol.364 (6438), p.648-652 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Amino Acid Sequence amino acid sequences Base Sequence binding proteins Biological and medical sciences Biotechnology Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism cDNA Cell cycle, cell proliferation Cell physiology Cellular biology Chromatin Assembly Factor-1 cloning complex DNA DNA-Binding Proteins Fundamental and applied biological sciences. Psychology Fungal Proteins - chemistry genes Hot Temperature Humanities and Social Sciences Humans letter man Molecular and cellular biology Molecular Sequence Data multidisciplinary Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism nucleotide sequence nucleotide sequences predictions Protein Binding protein p48 Proteins RbAp48 gene Recombinant Proteins - metabolism Retinoblastoma Protein - metabolism retinoblastoma-binding protein Retinoblastoma-Binding Protein 4 Saccharomyces cerevisiae Saccharomyces cerevisiae - physiology Saccharomyces cerevisiae Proteins Science Science (multidisciplinary) Sequence Homology, Amino Acid Tumor Cells, Cultured tumor suppressor genes Yeast Yeasts |
| title | retinoblastoma-binding protein related to a negative regulator of Ras in yeast |
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