Autoreactive T cells from a type I diabetic recognize multiple class II products

Mononuclear cells obtained from a child at the acute presentation of type I diabetes were stimulated in vitro with human insulin followed by IL-2 and IL-4. All of the T-cell clones isolated from this stimulation were autoreactive, recognizing autologous B cells in the absence of insulin or other exo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human immunology 1993-04, Vol.36 (4), p.219-226
Hauptverfasser:	Miller, Geraldine, Nepom, Gerald T., Reich, Martha B., Thomas, James W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Antibodies, Monoclonal antigen-presenting cell Antigen-Presenting Cells - immunology APC Autoantigens - immunology Biological and medical sciences Child Clone Cells Diabetes Mellitus, Type 1 - immunology Diabetes. Impaired glucose tolerance EBV Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epstein-Barr virus Etiopathogenesis. Screening. Investigations. Target tissue resistance HLA-DR Antigens - immunology Humans IDDM IL-2 IL-4 Insulin - immunology insulin-dependent diabetes mellitus interleukin 2 interleukin 4 Interleukins - immunology LCL lymphoblastoid cell line Lymphocyte Activation - immunology mAb major histocompatibility complex Male Medical sciences MHC monoclonal antibody recombinant human insulin rHins T-lymphocyte clone T-Lymphocytes - immunology TLC Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!