Pharmacological studies of FUT-175, nafamstat mesilate: IV. Effects on coagulation, platelets and fibrinolysis

Inhibitory effects of FUT-175 (nafamstat mesilate) on coagulation, platelets and fibrinolysis were examined. 1) FUT-175 prolonged activated partial thromboplastin time, thrombin time and prothrombin time in rabbit plasma. 2) FUT-175 prolonged these coagulation times in human plasma at lower concentr...

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Veröffentlicht in:	Folia Pharmacologica Japonica 1984, Vol.84(5), pp.417-428
Hauptverfasser:	KOSHIYAMA, Yoshiko, OZEKI, Masayuki, MOTOYOSHI, Akemi, FUJITA, Mitsunobu, IWAKI, Masahiro, AOYAMA, Takuo
Format:	Artikel
Sprache:	jpn
Schlagworte:	Animals Anticoagulants Antifibrinolytic Agents Bleeding Time Clot Retraction Dogs Guanidines - pharmacology Humans In Vitro Techniques Lipopolysaccharides - antagonists & inhibitors Male Mice Mice, Inbred ICR Platelet Aggregation - drug effects Rabbits Species Specificity Urokinase-Type Plasminogen Activator - antagonists & inhibitors
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