Growth hormone secretion in premenopausal women before and after ovariectomy: effect of hormone replacement therapy
To evaluate the GH response to growth hormone-releasing hormone (GH-RH) stimulation in premenopausal women before and after ovariectomy and after 1 month of estrogen replacement therapy (ERT). Ten women 42 to 49 years of age awaiting combined hysterectomy and ovariectomy for a variety of benign gyne...
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| Veröffentlicht in: | Fertility and sterility 1993-08, Vol.60 (2), p.268-271 |
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| container_issue | 2 |
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| container_title | Fertility and sterility |
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| creator | De Leo, Vincenzo Lanzetta, Danila D’Antona, Donato Danero, Secondo |
| description | To evaluate the GH response to growth hormone-releasing hormone (GH-RH) stimulation in premenopausal women before and after ovariectomy and after 1 month of estrogen replacement therapy (ERT).
Ten women 42 to 49 years of age awaiting combined hysterectomy and ovariectomy for a variety of benign gynecological conditions.
Endocrine status was determined by assay of basal levels of gonadotropins (LH, FSH), E2, P, and PRL. Stimulation with GH-RH was performed before and 8 to 10 days after ovariectomy, and after a month of ERT.
A significant reduction in GH response to GH-RH was observed after ovariectomy. Estrogen replacement therapy restored GH response to presurgical levels.
The results support the role of E2in the stimulated secretion of GH and suggest that ERT increases pituitary stores of GH. |
| doi_str_mv | 10.1016/S0015-0282(16)56095-6 |
| format | Article |
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Ten women 42 to 49 years of age awaiting combined hysterectomy and ovariectomy for a variety of benign gynecological conditions.
Endocrine status was determined by assay of basal levels of gonadotropins (LH, FSH), E2, P, and PRL. Stimulation with GH-RH was performed before and 8 to 10 days after ovariectomy, and after a month of ERT.
A significant reduction in GH response to GH-RH was observed after ovariectomy. Estrogen replacement therapy restored GH response to presurgical levels.
The results support the role of E2in the stimulated secretion of GH and suggest that ERT increases pituitary stores of GH.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)56095-6</identifier><identifier>PMID: 8339822</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Estradiol - blood ; Estrogen Replacement Therapy ; estrogens ; Female ; Growth hormone ; Growth Hormone - metabolism ; Growth Hormone-Releasing Hormone - pharmacology ; Hormones. Endocrine system ; Humans ; Medical sciences ; Menopause ; Middle Aged ; Ovariectomy ; Pharmacology. Drug treatments ; premenopause</subject><ispartof>Fertility and sterility, 1993-08, Vol.60 (2), p.268-271</ispartof><rights>1993 American Society for Reproductive Medicine</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-4fd495f524765fd2044b033faeb1b2ecc7e7cda1903a8974cc5664cb7eb113d73</citedby><cites>FETCH-LOGICAL-c389t-4fd495f524765fd2044b033faeb1b2ecc7e7cda1903a8974cc5664cb7eb113d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028216560956$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4844075$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8339822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Leo, Vincenzo</creatorcontrib><creatorcontrib>Lanzetta, Danila</creatorcontrib><creatorcontrib>D’Antona, Donato</creatorcontrib><creatorcontrib>Danero, Secondo</creatorcontrib><title>Growth hormone secretion in premenopausal women before and after ovariectomy: effect of hormone replacement therapy</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>To evaluate the GH response to growth hormone-releasing hormone (GH-RH) stimulation in premenopausal women before and after ovariectomy and after 1 month of estrogen replacement therapy (ERT).
Ten women 42 to 49 years of age awaiting combined hysterectomy and ovariectomy for a variety of benign gynecological conditions.
Endocrine status was determined by assay of basal levels of gonadotropins (LH, FSH), E2, P, and PRL. Stimulation with GH-RH was performed before and 8 to 10 days after ovariectomy, and after a month of ERT.
A significant reduction in GH response to GH-RH was observed after ovariectomy. Estrogen replacement therapy restored GH response to presurgical levels.
The results support the role of E2in the stimulated secretion of GH and suggest that ERT increases pituitary stores of GH.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Estradiol - blood</subject><subject>Estrogen Replacement Therapy</subject><subject>estrogens</subject><subject>Female</subject><subject>Growth hormone</subject><subject>Growth Hormone - metabolism</subject><subject>Growth Hormone-Releasing Hormone - pharmacology</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Ovariectomy</subject><subject>Pharmacology. Drug treatments</subject><subject>premenopause</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1q3DAURkVpSSdJHyGgRSntwq1k_dnZhBCatBDooulayPIVo2JbzpUnw7x9NZlhtl1Jl-_cT-IQcsXZV864_vabMa4qVjf1Z66_KM1aVek3ZMWV0pXSSrwlqxPynpzn_Jcxprmpz8hZI0Tb1PWK5AdM22VN1wnHNAHN4BGWmCYaJzojjDCl2W2yG-g2lYF2EBICdVNPXVgAaXpxGMEvadxdUwihXGkKp0KEeXB-37PQZQ3o5t0leRfckOHD8bwgf-6_P939qB5_Pfy8u32svGjapZKhl60KqpZGq9DXTMqOCREcdLyrwXsDxveOt0y4pjXSe6W19J0pORe9ERfk06F3xvS8gbzYMWYPw-AmSJtsjWq0Ym1TQHUAPaacEYKdMY4Od5Yzu5dtX2XbvUlbplfZVpe9q-MDm26E_rR1tFvyj8fcZe-GgG7yMZ8w2UjJjCrYzQGDIuMlAtrsI0we-ojFpu1T_M9H_gHrYJ3w</recordid><startdate>19930801</startdate><enddate>19930801</enddate><creator>De Leo, Vincenzo</creator><creator>Lanzetta, Danila</creator><creator>D’Antona, Donato</creator><creator>Danero, Secondo</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930801</creationdate><title>Growth hormone secretion in premenopausal women before and after ovariectomy: effect of hormone replacement therapy</title><author>De Leo, Vincenzo ; Lanzetta, Danila ; D’Antona, Donato ; Danero, Secondo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-4fd495f524765fd2044b033faeb1b2ecc7e7cda1903a8974cc5664cb7eb113d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Estradiol - blood</topic><topic>Estrogen Replacement Therapy</topic><topic>estrogens</topic><topic>Female</topic><topic>Growth hormone</topic><topic>Growth Hormone - metabolism</topic><topic>Growth Hormone-Releasing Hormone - pharmacology</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Menopause</topic><topic>Middle Aged</topic><topic>Ovariectomy</topic><topic>Pharmacology. Drug treatments</topic><topic>premenopause</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Leo, Vincenzo</creatorcontrib><creatorcontrib>Lanzetta, Danila</creatorcontrib><creatorcontrib>D’Antona, Donato</creatorcontrib><creatorcontrib>Danero, Secondo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Leo, Vincenzo</au><au>Lanzetta, Danila</au><au>D’Antona, Donato</au><au>Danero, Secondo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Growth hormone secretion in premenopausal women before and after ovariectomy: effect of hormone replacement therapy</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1993-08-01</date><risdate>1993</risdate><volume>60</volume><issue>2</issue><spage>268</spage><epage>271</epage><pages>268-271</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>To evaluate the GH response to growth hormone-releasing hormone (GH-RH) stimulation in premenopausal women before and after ovariectomy and after 1 month of estrogen replacement therapy (ERT).
Ten women 42 to 49 years of age awaiting combined hysterectomy and ovariectomy for a variety of benign gynecological conditions.
Endocrine status was determined by assay of basal levels of gonadotropins (LH, FSH), E2, P, and PRL. Stimulation with GH-RH was performed before and 8 to 10 days after ovariectomy, and after a month of ERT.
A significant reduction in GH response to GH-RH was observed after ovariectomy. Estrogen replacement therapy restored GH response to presurgical levels.
The results support the role of E2in the stimulated secretion of GH and suggest that ERT increases pituitary stores of GH.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8339822</pmid><doi>10.1016/S0015-0282(16)56095-6</doi><tpages>4</tpages></addata></record> |
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| ispartof | Fertility and sterility, 1993-08, Vol.60 (2), p.268-271 |
| issn | 0015-0282 1556-5653 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Estradiol - blood Estrogen Replacement Therapy estrogens Female Growth hormone Growth Hormone - metabolism Growth Hormone-Releasing Hormone - pharmacology Hormones. Endocrine system Humans Medical sciences Menopause Middle Aged Ovariectomy Pharmacology. Drug treatments premenopause |
| title | Growth hormone secretion in premenopausal women before and after ovariectomy: effect of hormone replacement therapy |
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