FLT4 Receptor Tyrosine Kinase Gene Mapping to Chromosome Band 5q35 in Relation to the t(2;5), t(5;6), and t(3;5) Translocations
FLT4 is a recently cloned receptor tyrosine kinase cDNA, which is characterized by seven immunoglobulin‐like loops in its extracellular domain. We have previously mapped the FLT4 gene to chromosome segment 5q33‐qter using somatic cell hybrids. Here we have refined the localization to band 5q35 by fl...
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| Veröffentlicht in: | Genes chromosomes & cancer 1993-07, Vol.7 (3), p.144-151 |
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| container_title | Genes chromosomes & cancer |
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| creator | Armstrong, Elina Kastury, Kumar Aprelikova, Olga Bullrich, Florencia Nezelof, Christian Gogusev, Jean Wasmuth, John J. Alitalo, Kari Morris, Steven Huebner, Kay |
| description | FLT4 is a recently cloned receptor tyrosine kinase cDNA, which is characterized by seven immunoglobulin‐like loops in its extracellular domain. We have previously mapped the FLT4 gene to chromosome segment 5q33‐qter using somatic cell hybrids. Here we have refined the localization to band 5q35 by fluorescence in situ hybridization and show that the gene is translocated to chromosomes 2 and 6 in the t(2;5)(p23;q35) and t(5;6)(q35;p21) translocations, respectively, of Ki‐1‐positive lymphomas, as well as to chromosome 3 in the t(3;5)(q25.1;q34) translocation, which is occasionally found in myelodysplastic syndromes and acute myeloid leukemia. No evidence was obtained for a rearrangement or deregulation of the translocated FLT4 gene. We further show that abundant FLT4 mRNA expression occurs only in erythroid and megakaryoblastoid cell lines among nine leukemia cell lines studied. © 1993 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/gcc.2870070306 |
| format | Article |
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We have previously mapped the FLT4 gene to chromosome segment 5q33‐qter using somatic cell hybrids. Here we have refined the localization to band 5q35 by fluorescence in situ hybridization and show that the gene is translocated to chromosomes 2 and 6 in the t(2;5)(p23;q35) and t(5;6)(q35;p21) translocations, respectively, of Ki‐1‐positive lymphomas, as well as to chromosome 3 in the t(3;5)(q25.1;q34) translocation, which is occasionally found in myelodysplastic syndromes and acute myeloid leukemia. No evidence was obtained for a rearrangement or deregulation of the translocated FLT4 gene. We further show that abundant FLT4 mRNA expression occurs only in erythroid and megakaryoblastoid cell lines among nine leukemia cell lines studied. © 1993 Wiley‐Liss, Inc.</description><identifier>ISSN: 1045-2257</identifier><identifier>EISSN: 1098-2264</identifier><identifier>DOI: 10.1002/gcc.2870070306</identifier><identifier>PMID: 7687867</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Chromosome Mapping ; Chromosomes, Human, Pair 2 ; Chromosomes, Human, Pair 3 ; Chromosomes, Human, Pair 5 ; Chromosomes, Human, Pair 6 ; DNA, Neoplasm - genetics ; Gene Expression ; Humans ; In Situ Hybridization ; In Vitro Techniques ; Leukemia - genetics ; Microscopy, Fluorescence ; Protein-Tyrosine Kinases - genetics ; Receptors, Cell Surface - genetics ; RNA, Messenger - genetics ; RNA, Neoplasm - genetics ; Translocation, Genetic ; Tumor Cells, Cultured ; Vascular Endothelial Growth Factor Receptor-3</subject><ispartof>Genes chromosomes & cancer, 1993-07, Vol.7 (3), p.144-151</ispartof><rights>Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3786-627df054e780aad5fb13f926250b1dbf57700fbbf05d6c785c35091db8226b4f3</citedby><cites>FETCH-LOGICAL-c3786-627df054e780aad5fb13f926250b1dbf57700fbbf05d6c785c35091db8226b4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fgcc.2870070306$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fgcc.2870070306$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7687867$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Armstrong, Elina</creatorcontrib><creatorcontrib>Kastury, Kumar</creatorcontrib><creatorcontrib>Aprelikova, Olga</creatorcontrib><creatorcontrib>Bullrich, Florencia</creatorcontrib><creatorcontrib>Nezelof, Christian</creatorcontrib><creatorcontrib>Gogusev, Jean</creatorcontrib><creatorcontrib>Wasmuth, John J.</creatorcontrib><creatorcontrib>Alitalo, Kari</creatorcontrib><creatorcontrib>Morris, Steven</creatorcontrib><creatorcontrib>Huebner, Kay</creatorcontrib><title>FLT4 Receptor Tyrosine Kinase Gene Mapping to Chromosome Band 5q35 in Relation to the t(2;5), t(5;6), and t(3;5) Translocations</title><title>Genes chromosomes & cancer</title><addtitle>Genes Chromosom. Cancer</addtitle><description>FLT4 is a recently cloned receptor tyrosine kinase cDNA, which is characterized by seven immunoglobulin‐like loops in its extracellular domain. We have previously mapped the FLT4 gene to chromosome segment 5q33‐qter using somatic cell hybrids. Here we have refined the localization to band 5q35 by fluorescence in situ hybridization and show that the gene is translocated to chromosomes 2 and 6 in the t(2;5)(p23;q35) and t(5;6)(q35;p21) translocations, respectively, of Ki‐1‐positive lymphomas, as well as to chromosome 3 in the t(3;5)(q25.1;q34) translocation, which is occasionally found in myelodysplastic syndromes and acute myeloid leukemia. No evidence was obtained for a rearrangement or deregulation of the translocated FLT4 gene. We further show that abundant FLT4 mRNA expression occurs only in erythroid and megakaryoblastoid cell lines among nine leukemia cell lines studied. © 1993 Wiley‐Liss, Inc.</description><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 2</subject><subject>Chromosomes, Human, Pair 3</subject><subject>Chromosomes, Human, Pair 5</subject><subject>Chromosomes, Human, Pair 6</subject><subject>DNA, Neoplasm - genetics</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>In Vitro Techniques</subject><subject>Leukemia - genetics</subject><subject>Microscopy, Fluorescence</subject><subject>Protein-Tyrosine Kinases - genetics</subject><subject>Receptors, Cell Surface - genetics</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Neoplasm - genetics</subject><subject>Translocation, Genetic</subject><subject>Tumor Cells, Cultured</subject><subject>Vascular Endothelial Growth Factor Receptor-3</subject><issn>1045-2257</issn><issn>1098-2264</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAURS1UxFfZskPyqqJSM3Xs2E7EqkRlWjFQCQW1O8txHHCbxMHOiM6qf71vmBGoq67ek-95V9ZB6CQls5QQ-vHemBnNJSGSMCJ20EFKijyhVGRv1nvGYedyHx3G-JMQIljB99CeFLnMhTxAfy4XVYZvrbHj5AOuVsFHN1h85QYdLZ5b2K_1OLrhHk8elw_B9z763uILPTSYPzKO3QAFnZ6cH9bM9GDxdEbP-fsPMPm5gLlmpzMGb7gKeoidN898fIt2W91Fe7ydR-ju8nNVfkkW3-Zfy0-LxDD4aCKobFrCMytzonXD2zplbUEF5aROm7rlEgy0dQ1MI4zMuWGcFJDkYKLOWnaE3m16x-AflzZOqnfR2K7Tg_XLqCTPQQ3jAM42oAETMdhWjcH1OqxUStTauALj6tU4HJxum5d1b5sXfKsY8mKTP7nOrv7TpuZl-U93srl1cbK_X251-KWgWXL1_Waurq4vqhvOfijK_gLLVpg2</recordid><startdate>199307</startdate><enddate>199307</enddate><creator>Armstrong, Elina</creator><creator>Kastury, Kumar</creator><creator>Aprelikova, Olga</creator><creator>Bullrich, Florencia</creator><creator>Nezelof, Christian</creator><creator>Gogusev, Jean</creator><creator>Wasmuth, John J.</creator><creator>Alitalo, Kari</creator><creator>Morris, Steven</creator><creator>Huebner, Kay</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199307</creationdate><title>FLT4 Receptor Tyrosine Kinase Gene Mapping to Chromosome Band 5q35 in Relation to the t(2;5), t(5;6), and t(3;5) Translocations</title><author>Armstrong, Elina ; Kastury, Kumar ; Aprelikova, Olga ; Bullrich, Florencia ; Nezelof, Christian ; Gogusev, Jean ; Wasmuth, John J. ; Alitalo, Kari ; Morris, Steven ; Huebner, Kay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3786-627df054e780aad5fb13f926250b1dbf57700fbbf05d6c785c35091db8226b4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 2</topic><topic>Chromosomes, Human, Pair 3</topic><topic>Chromosomes, Human, Pair 5</topic><topic>Chromosomes, Human, Pair 6</topic><topic>DNA, Neoplasm - genetics</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>In Vitro Techniques</topic><topic>Leukemia - genetics</topic><topic>Microscopy, Fluorescence</topic><topic>Protein-Tyrosine Kinases - genetics</topic><topic>Receptors, Cell Surface - genetics</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Neoplasm - genetics</topic><topic>Translocation, Genetic</topic><topic>Tumor Cells, Cultured</topic><topic>Vascular Endothelial Growth Factor Receptor-3</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Armstrong, Elina</creatorcontrib><creatorcontrib>Kastury, Kumar</creatorcontrib><creatorcontrib>Aprelikova, Olga</creatorcontrib><creatorcontrib>Bullrich, Florencia</creatorcontrib><creatorcontrib>Nezelof, Christian</creatorcontrib><creatorcontrib>Gogusev, Jean</creatorcontrib><creatorcontrib>Wasmuth, John J.</creatorcontrib><creatorcontrib>Alitalo, Kari</creatorcontrib><creatorcontrib>Morris, Steven</creatorcontrib><creatorcontrib>Huebner, Kay</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Genes chromosomes & cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Armstrong, Elina</au><au>Kastury, Kumar</au><au>Aprelikova, Olga</au><au>Bullrich, Florencia</au><au>Nezelof, Christian</au><au>Gogusev, Jean</au><au>Wasmuth, John J.</au><au>Alitalo, Kari</au><au>Morris, Steven</au><au>Huebner, Kay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FLT4 Receptor Tyrosine Kinase Gene Mapping to Chromosome Band 5q35 in Relation to the t(2;5), t(5;6), and t(3;5) Translocations</atitle><jtitle>Genes chromosomes & cancer</jtitle><addtitle>Genes Chromosom. Cancer</addtitle><date>1993-07</date><risdate>1993</risdate><volume>7</volume><issue>3</issue><spage>144</spage><epage>151</epage><pages>144-151</pages><issn>1045-2257</issn><eissn>1098-2264</eissn><abstract>FLT4 is a recently cloned receptor tyrosine kinase cDNA, which is characterized by seven immunoglobulin‐like loops in its extracellular domain. We have previously mapped the FLT4 gene to chromosome segment 5q33‐qter using somatic cell hybrids. Here we have refined the localization to band 5q35 by fluorescence in situ hybridization and show that the gene is translocated to chromosomes 2 and 6 in the t(2;5)(p23;q35) and t(5;6)(q35;p21) translocations, respectively, of Ki‐1‐positive lymphomas, as well as to chromosome 3 in the t(3;5)(q25.1;q34) translocation, which is occasionally found in myelodysplastic syndromes and acute myeloid leukemia. No evidence was obtained for a rearrangement or deregulation of the translocated FLT4 gene. 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| ispartof | Genes chromosomes & cancer, 1993-07, Vol.7 (3), p.144-151 |
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| subjects | Chromosome Mapping Chromosomes, Human, Pair 2 Chromosomes, Human, Pair 3 Chromosomes, Human, Pair 5 Chromosomes, Human, Pair 6 DNA, Neoplasm - genetics Gene Expression Humans In Situ Hybridization In Vitro Techniques Leukemia - genetics Microscopy, Fluorescence Protein-Tyrosine Kinases - genetics Receptors, Cell Surface - genetics RNA, Messenger - genetics RNA, Neoplasm - genetics Translocation, Genetic Tumor Cells, Cultured Vascular Endothelial Growth Factor Receptor-3 |
| title | FLT4 Receptor Tyrosine Kinase Gene Mapping to Chromosome Band 5q35 in Relation to the t(2;5), t(5;6), and t(3;5) Translocations |
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