Fluoxetine Treatment of Severe Self-Injury in Young Adults with Mental Retardation
Dysfunction of the serotonergic system has been implicated in the development and maintenance of self-injury in some persons with mental retardation. Several preliminary reports have suggested that fluoxetine, a drug that blocks the reuptake of serotonin, may decrease self-injury in these individual...
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| Veröffentlicht in: | Journal of the American Academy of Child and Adolescent Psychiatry 1993-07, Vol.32 (4), p.865-869 |
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| container_issue | 4 |
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| container_title | Journal of the American Academy of Child and Adolescent Psychiatry |
| container_volume | 32 |
| creator | RICKETTS, ROBERT W. GOZA, AMANDA B. ELLIS, CYNTHIA R. SINGH, YADHU N. SINGH, NIRBHAY N. COOKE, JOHN C. |
| description | Dysfunction of the serotonergic system has been implicated in the development and maintenance of self-injury in some persons with mental retardation. Several preliminary reports have suggested that fluoxetine, a drug that blocks the reuptake of serotonin, may decrease self-injury in these individuals. Of the 44 cases of self-injury treated with fluoxetine and previously reported in the literature, 42 demonstrated a beneficial response to the drug. We report four additional cases of adults with mental retardation whose self-injury was treated with fluoxetine. Each of these individuals benefited from fluoxetine to some extent, with average decreases in self-injury ranging from 20% to 88% when compared with baseline levels. These findings, combined with those from previously published case studies, emphasize the need for well-controlled studies to more adequately assess the effects of fluoxetine on self-injury. |
| doi_str_mv | 10.1097/00004583-199307000-00024 |
| format | Article |
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Several preliminary reports have suggested that fluoxetine, a drug that blocks the reuptake of serotonin, may decrease self-injury in these individuals. Of the 44 cases of self-injury treated with fluoxetine and previously reported in the literature, 42 demonstrated a beneficial response to the drug. We report four additional cases of adults with mental retardation whose self-injury was treated with fluoxetine. Each of these individuals benefited from fluoxetine to some extent, with average decreases in self-injury ranging from 20% to 88% when compared with baseline levels. These findings, combined with those from previously published case studies, emphasize the need for well-controlled studies to more adequately assess the effects of fluoxetine on self-injury.</description><identifier>ISSN: 0890-8567</identifier><identifier>EISSN: 1527-5418</identifier><identifier>DOI: 10.1097/00004583-199307000-00024</identifier><identifier>PMID: 8340311</identifier><identifier>CODEN: JAAPEE</identifier><language>eng</language><publisher>Hagerstown, MD: Elsevier Inc</publisher><subject>Adult ; Behavior Therapy ; Biological and medical sciences ; Combined Modality Therapy ; Dose-Response Relationship, Drug ; Drug therapy ; Female ; fluoxetine ; Fluoxetine - therapeutic use ; Humans ; Intellectual disabilities ; Intellectual Disability - drug therapy ; Intellectual Disability - psychology ; Male ; Medical research ; Medical sciences ; mental retardation ; Miscellaneous ; Neuropharmacology ; Pharmacology. Drug treatments ; Self-Injurious Behavior - drug therapy ; Self-Injurious Behavior - psychology ; self-injury ; serotonergic dysfunction</subject><ispartof>Journal of the American Academy of Child and Adolescent Psychiatry, 1993-07, Vol.32 (4), p.865-869</ispartof><rights>1993 The American Academy of Child and Adolescent Psychiatry</rights><rights>1993 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Jul 1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-25a342fa8d2ff1db5d0a410814f1dac74e4bfe74d6116202602b4eb80fd058853</citedby><cites>FETCH-LOGICAL-c425t-25a342fa8d2ff1db5d0a410814f1dac74e4bfe74d6116202602b4eb80fd058853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1097/00004583-199307000-00024$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,30982,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4796383$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8340311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RICKETTS, ROBERT W.</creatorcontrib><creatorcontrib>GOZA, AMANDA B.</creatorcontrib><creatorcontrib>ELLIS, CYNTHIA R.</creatorcontrib><creatorcontrib>SINGH, YADHU N.</creatorcontrib><creatorcontrib>SINGH, NIRBHAY N.</creatorcontrib><creatorcontrib>COOKE, JOHN C.</creatorcontrib><title>Fluoxetine Treatment of Severe Self-Injury in Young Adults with Mental Retardation</title><title>Journal of the American Academy of Child and Adolescent Psychiatry</title><addtitle>J Am Acad Child Adolesc Psychiatry</addtitle><description>Dysfunction of the serotonergic system has been implicated in the development and maintenance of self-injury in some persons with mental retardation. Several preliminary reports have suggested that fluoxetine, a drug that blocks the reuptake of serotonin, may decrease self-injury in these individuals. Of the 44 cases of self-injury treated with fluoxetine and previously reported in the literature, 42 demonstrated a beneficial response to the drug. We report four additional cases of adults with mental retardation whose self-injury was treated with fluoxetine. Each of these individuals benefited from fluoxetine to some extent, with average decreases in self-injury ranging from 20% to 88% when compared with baseline levels. These findings, combined with those from previously published case studies, emphasize the need for well-controlled studies to more adequately assess the effects of fluoxetine on self-injury.</description><subject>Adult</subject><subject>Behavior Therapy</subject><subject>Biological and medical sciences</subject><subject>Combined Modality Therapy</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug therapy</subject><subject>Female</subject><subject>fluoxetine</subject><subject>Fluoxetine - therapeutic use</subject><subject>Humans</subject><subject>Intellectual disabilities</subject><subject>Intellectual Disability - drug therapy</subject><subject>Intellectual Disability - psychology</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>mental retardation</subject><subject>Miscellaneous</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Self-Injurious Behavior - drug therapy</subject><subject>Self-Injurious Behavior - psychology</subject><subject>self-injury</subject><subject>serotonergic dysfunction</subject><issn>0890-8567</issn><issn>1527-5418</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkM9rFTEQgINY6rP6JwhBxNtqfm6yx1psLVQKbT14CtnNRPPYl9QkW-1_39T3fAcvHRiGYb4Zhg8hTMkHSgb1kbQQUvOODgMnqnVdSyaeoRWVTHVSUP0crYgeSKdlr16gl6WsG0KV1ofoUHNBOKUrdHU6L-kP1BAB32SwdQOx4uTxNdxBhlZm353H9ZLvcYj4e1riD3zslrkW_DvUn_hr4-2Mr6Da7GwNKb5CB97OBV7v6hH6dvr55uRLd3F5dn5yfNFNgsnaMWm5YN5qx7ynbpSOWEGJpqJ1dlICxOhBCddT2jPCesJGAaMm3hGpteRH6P327m1OvxYo1WxCmWCebYS0FKOk7plmj-Db_8B1WnJsvxlGWc_poEmD9Baaciolgze3OWxsvjeUmEfn5p9zs3du_jpvq29295dxA26_uJPc5u92c1smO_ts4xTKHhNq6LnmDfu0xaBJuwuQTZkCxAlcyDBV41J4-pcH8PicHA</recordid><startdate>19930701</startdate><enddate>19930701</enddate><creator>RICKETTS, ROBERT W.</creator><creator>GOZA, AMANDA B.</creator><creator>ELLIS, CYNTHIA R.</creator><creator>SINGH, YADHU N.</creator><creator>SINGH, NIRBHAY N.</creator><creator>COOKE, JOHN C.</creator><general>Elsevier Inc</general><general>Lippincott</general><general>Elsevier BV</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>19930701</creationdate><title>Fluoxetine Treatment of Severe Self-Injury in Young Adults with Mental Retardation</title><author>RICKETTS, ROBERT W. ; GOZA, AMANDA B. ; ELLIS, CYNTHIA R. ; SINGH, YADHU N. ; SINGH, NIRBHAY N. ; COOKE, JOHN C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-25a342fa8d2ff1db5d0a410814f1dac74e4bfe74d6116202602b4eb80fd058853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Behavior Therapy</topic><topic>Biological and medical sciences</topic><topic>Combined Modality Therapy</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug therapy</topic><topic>Female</topic><topic>fluoxetine</topic><topic>Fluoxetine - therapeutic use</topic><topic>Humans</topic><topic>Intellectual disabilities</topic><topic>Intellectual Disability - drug therapy</topic><topic>Intellectual Disability - psychology</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>mental retardation</topic><topic>Miscellaneous</topic><topic>Neuropharmacology</topic><topic>Pharmacology. 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| ispartof | Journal of the American Academy of Child and Adolescent Psychiatry, 1993-07, Vol.32 (4), p.865-869 |
| issn | 0890-8567 1527-5418 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Journals@Ovid Complete; Applied Social Sciences Index & Abstracts (ASSIA) |
| subjects | Adult Behavior Therapy Biological and medical sciences Combined Modality Therapy Dose-Response Relationship, Drug Drug therapy Female fluoxetine Fluoxetine - therapeutic use Humans Intellectual disabilities Intellectual Disability - drug therapy Intellectual Disability - psychology Male Medical research Medical sciences mental retardation Miscellaneous Neuropharmacology Pharmacology. Drug treatments Self-Injurious Behavior - drug therapy Self-Injurious Behavior - psychology self-injury serotonergic dysfunction |
| title | Fluoxetine Treatment of Severe Self-Injury in Young Adults with Mental Retardation |
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