Effects of diltiazem on the calcium accumulation and atp synthesis simultaneously sustained by isolated rat heart mitochondria
1. The effects of diltiazem have been investigated in isolated rat heart mitochondria exposed to conditions possibly attained in ischemia-damaged cells. 2. The results obtained indicate that diltiazem, at the concentrations expected within cells following pharmacological treatment, does not signific...
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| Veröffentlicht in: | Comparative biochemistry and physiology. C, Comparative pharmacology Comparative pharmacology, 1993-05, Vol.105 (1), p.43-47 |
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| container_end_page | 47 |
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| container_issue | 1 |
| container_start_page | 43 |
| container_title | Comparative biochemistry and physiology. C, Comparative pharmacology |
| container_volume | 105 |
| creator | Branca, Donata Roberti, Michela S. Venudo, Antonella Arsie, Patrizia Simonato, Barbara Scutari, Guido |
| description | 1. The effects of diltiazem have been investigated in isolated rat heart mitochondria exposed to conditions possibly attained in ischemia-damaged cells.
2. The results obtained indicate that diltiazem, at the concentrations expected within cells following pharmacological treatment, does not significantly affect the mitochondrial calcium content.
3. Diltiazem did not appear to modify ATP synthesis, and hence the capacity of mitochondria to sustain the ATP-requiring processes needed for the recovery of cardiac cells. |
| doi_str_mv | 10.1016/0742-8413(93)90055-P |
| format | Article |
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2. The results obtained indicate that diltiazem, at the concentrations expected within cells following pharmacological treatment, does not significantly affect the mitochondrial calcium content.
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2. The results obtained indicate that diltiazem, at the concentrations expected within cells following pharmacological treatment, does not significantly affect the mitochondrial calcium content.
3. Diltiazem did not appear to modify ATP synthesis, and hence the capacity of mitochondria to sustain the ATP-requiring processes needed for the recovery of cardiac cells.</description><subject>Adenosine Triphosphate - biosynthesis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium - metabolism</subject><subject>Calcium - pharmacokinetics</subject><subject>Calcium - pharmacology</subject><subject>Cardiovascular system</subject><subject>Culture Media</subject><subject>Cytoplasm - metabolism</subject><subject>Diltiazem - pharmacology</subject><subject>Egtazic Acid - pharmacology</subject><subject>Homeostasis - drug effects</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Mitochondria, Heart - drug effects</subject><subject>Mitochondria, Heart - metabolism</subject><subject>Myocardial Ischemia - metabolism</subject><subject>Pharmacology. 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| identifier | ISSN: 0306-4492 |
| ispartof | Comparative biochemistry and physiology. C, Comparative pharmacology, 1993-05, Vol.105 (1), p.43-47 |
| issn | 0306-4492 0742-8413 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adenosine Triphosphate - biosynthesis Animals Biological and medical sciences Calcium - metabolism Calcium - pharmacokinetics Calcium - pharmacology Cardiovascular system Culture Media Cytoplasm - metabolism Diltiazem - pharmacology Egtazic Acid - pharmacology Homeostasis - drug effects Medical sciences Miscellaneous Mitochondria, Heart - drug effects Mitochondria, Heart - metabolism Myocardial Ischemia - metabolism Pharmacology. Drug treatments Rats Rats, Wistar Sodium - pharmacology |
| title | Effects of diltiazem on the calcium accumulation and atp synthesis simultaneously sustained by isolated rat heart mitochondria |
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