Sphingosine, W‐7, and Trifluoperazine Inhibit the Elevation in Cytosolic Calcium Induced by High K+Depolarization in Synaptosomes

: A possible role for protein kinases in the regulation of free cytosolic Ca2+ levels in nerve endings was investigated by testing the effect of several kinase inhibitors on the increase in cytosolic Ca2+ (monitored with the Ca2+‐sensitive dye fura‐2) induced by depolarization with 15 or 30 mM K+. T...

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Veröffentlicht in:	Journal of neurochemistry 1993-08, Vol.61 (2), p.443-450
Hauptverfasser:	Sitges, Maria, Talamo, Barbara R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry and metabolism Biological and medical sciences Brain - ultrastructure Calcium - metabolism Central nervous system Cytosol - metabolism Electrophysiology Fundamental and applied biological sciences. Psychology Fura‐2AM K+ depolarization Potassium - pharmacology Protein Kinase Inhibitors Rats Rats, Sprague-Dawley Sphingosine Sphingosine - pharmacology Sulfonamides - pharmacology Synaptosomes Synaptosomes - drug effects Synaptosomes - physiology Trifluoperazine Trifluoperazine - pharmacology Vertebrates: nervous system and sense organs W‐7
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