Expression and Factor-Dependent Modulation of the Interleukin-3 Receptor Subunits on Human Hematopoietic Cells

Interleukin-3 (IL-3) regulates growth and differentiation of multipotential as well as lineage-committed progenitor cells. The human IL-3 receptor (IL-3R) consists of the α and common β (βc) subunits. The α subunit (IL-3Rα) is specific for IL-3 and binds IL-3 with low affinity. In contrast, the βC s...

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Veröffentlicht in:	Blood 1993-08, Vol.82 (3), p.752-761
Hauptverfasser:	Sato, Noriko, Caux, Christophe, Kitamura, Toshio, Watanabe, Yoshinari, Arai, Ken-ichi, Banchereau, Jacques, Miyajima, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal Antigens, CD - analysis Antigens, CD34 Biological and medical sciences Bone Marrow Cells Cell differentiation, maturation, development, hematopoiesis Cell Line Cell physiology Cytokines - pharmacology Fetal Blood Flow Cytometry Fundamental and applied biological sciences. Psychology Hematopoietic Stem Cells - metabolism Humans Immunophenotyping In Vitro Techniques Molecular and cellular biology Precipitin Tests Receptors, Interleukin-3 - immunology Receptors, Interleukin-3 - metabolism
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