The Determination of Amphetamine and Methamphetamine in a Lyophilized Human Urine Reference Material
The concentrations of amphetamine and methamphetamine in a new lyophilized human urine reference material (RM) were determined at the National Institute of Standards and Technology, in cooperation with the College of American Pathologists. In order to minimize the possibility of undetected bias, two...
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Veröffentlicht in: | Journal of analytical toxicology 1993-05, Vol.17 (3), p.165-170 |
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description | The concentrations of amphetamine and methamphetamine in a new lyophilized human urine reference material (RM) were determined at the National Institute of Standards and Technology, in cooperation with the College of American Pathologists. In order to minimize the possibility of undetected bias, two different methods were developed. Both methods were based on isotope-dilution gas chromatography/mass spectrometry (GC/MS) with a deuterium-labeled standard. The first method used a solid phase extractor (SPE) to isolate the analytes, followed by forming the heptafluorobutyryl (HFB) derivatives for measurement by GC/MS. The second method used another kind of SPE to isolate the analytes, followed by forming the N-trifluoroacetyl-1-prolyl chloride (TPC) derivatives for measurement by GC/MS. The RM consists of three levels of amphetamine, three levels of methamphetamine, and a blank. For amphetamine, the concentrations are 291, 558, and 1081 ng/mL of human urine. For methamphetamine, the concentrations are 311, 573, and 1137 ng/mL of human urine. |
doi_str_mv | 10.1093/jat/17.3.165 |
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For methamphetamine, the concentrations are 311, 573, and 1137 ng/mL of human urine.</description><identifier>ISSN: 0146-4760</identifier><identifier>EISSN: 1945-2403</identifier><identifier>DOI: 10.1093/jat/17.3.165</identifier><identifier>PMID: 8336490</identifier><identifier>CODEN: JATOD3</identifier><language>eng</language><publisher>Niles, IL: Oxford University Press</publisher><subject>Amphetamine ; Amphetamine - urine ; Biological and medical sciences ; Chloride ; Cooperation ; Drug addictions ; Freeze Drying ; Gas chromatography ; Gas Chromatography-Mass Spectrometry ; Humans ; Isomerism ; Mass spectroscopy ; Medical sciences ; Methamphetamine ; Methamphetamine - urine ; Reference Standards ; Solutions ; Toxicology ; Urine</subject><ispartof>Journal of analytical toxicology, 1993-05, Vol.17 (3), p.165-170</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-2b2f4f41ab368ecbcc4cf406b121464a0ec4c1df3938b8d42825327723edc87f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4746277$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8336490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ellerbe, P.</creatorcontrib><creatorcontrib>Long, T.</creatorcontrib><creatorcontrib>Welch, M.J.</creatorcontrib><title>The Determination of Amphetamine and Methamphetamine in a Lyophilized Human Urine Reference Material</title><title>Journal of analytical toxicology</title><addtitle>Journal of Analytical Toxicology</addtitle><description>The concentrations of amphetamine and methamphetamine in a new lyophilized human urine reference material (RM) were determined at the National Institute of Standards and Technology, in cooperation with the College of American Pathologists. In order to minimize the possibility of undetected bias, two different methods were developed. Both methods were based on isotope-dilution gas chromatography/mass spectrometry (GC/MS) with a deuterium-labeled standard. The first method used a solid phase extractor (SPE) to isolate the analytes, followed by forming the heptafluorobutyryl (HFB) derivatives for measurement by GC/MS. The second method used another kind of SPE to isolate the analytes, followed by forming the N-trifluoroacetyl-1-prolyl chloride (TPC) derivatives for measurement by GC/MS. The RM consists of three levels of amphetamine, three levels of methamphetamine, and a blank. For amphetamine, the concentrations are 291, 558, and 1081 ng/mL of human urine. For methamphetamine, the concentrations are 311, 573, and 1137 ng/mL of human urine.</description><subject>Amphetamine</subject><subject>Amphetamine - urine</subject><subject>Biological and medical sciences</subject><subject>Chloride</subject><subject>Cooperation</subject><subject>Drug addictions</subject><subject>Freeze Drying</subject><subject>Gas chromatography</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Humans</subject><subject>Isomerism</subject><subject>Mass spectroscopy</subject><subject>Medical sciences</subject><subject>Methamphetamine</subject><subject>Methamphetamine - urine</subject><subject>Reference Standards</subject><subject>Solutions</subject><subject>Toxicology</subject><subject>Urine</subject><issn>0146-4760</issn><issn>1945-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2LUzEUxYM4jLW6cytkIeJiXid5yUvS5VB1KnRQpANlNuG-vBua8X3U5BUc_3ozthRX4-rCOT8O3HMIecPZjLO5uLyH8ZLrmZhxVT0jEz6XVVFKJp6TCeNSFVIr9oK8TOmeMa6MEufk3Aih5JxNSLPeIv2II8Yu9DCGoaeDp1fdbosjZAkp9A29wXEL_2ihp0BXD8NuG9rwGxu63HfQ09v4aH5HjxF7h_QGcm6A9hU589AmfH28U3L7-dN6sSxWX6-_LK5WhZNcj0VZl156yaEWyqCrnZPOS6ZqXuY_JDDMAm-8mAtTm0aWpqxEqXUpsHFGezEl7w-5uzj83GMabReSw7aFHod9sroyilVc_hfMNZWa5Q6n5MPTYB5ASiNyn1NycUBdHFKK6O0uhg7iQ4b-cjYPZbm2IsdXGX97TN7XHTYn-LhM9t8dfUgOWh-hdyGdMKmlyq9nrDhgIY3462RD_GGVFrqyy82dXYhv6-u7zdpuxB-tnapx</recordid><startdate>19930501</startdate><enddate>19930501</enddate><creator>Ellerbe, P.</creator><creator>Long, T.</creator><creator>Welch, M.J.</creator><general>Oxford University Press</general><general>Preston</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19930501</creationdate><title>The Determination of Amphetamine and Methamphetamine in a Lyophilized Human Urine Reference Material</title><author>Ellerbe, P. ; Long, T. ; Welch, M.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-2b2f4f41ab368ecbcc4cf406b121464a0ec4c1df3938b8d42825327723edc87f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Amphetamine</topic><topic>Amphetamine - urine</topic><topic>Biological and medical sciences</topic><topic>Chloride</topic><topic>Cooperation</topic><topic>Drug addictions</topic><topic>Freeze Drying</topic><topic>Gas chromatography</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>Humans</topic><topic>Isomerism</topic><topic>Mass spectroscopy</topic><topic>Medical sciences</topic><topic>Methamphetamine</topic><topic>Methamphetamine - urine</topic><topic>Reference Standards</topic><topic>Solutions</topic><topic>Toxicology</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ellerbe, P.</creatorcontrib><creatorcontrib>Long, T.</creatorcontrib><creatorcontrib>Welch, M.J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of analytical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ellerbe, P.</au><au>Long, T.</au><au>Welch, M.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Determination of Amphetamine and Methamphetamine in a Lyophilized Human Urine Reference Material</atitle><jtitle>Journal of analytical toxicology</jtitle><addtitle>Journal of Analytical Toxicology</addtitle><date>1993-05-01</date><risdate>1993</risdate><volume>17</volume><issue>3</issue><spage>165</spage><epage>170</epage><pages>165-170</pages><issn>0146-4760</issn><eissn>1945-2403</eissn><coden>JATOD3</coden><abstract>The concentrations of amphetamine and methamphetamine in a new lyophilized human urine reference material (RM) were determined at the National Institute of Standards and Technology, in cooperation with the College of American Pathologists. In order to minimize the possibility of undetected bias, two different methods were developed. Both methods were based on isotope-dilution gas chromatography/mass spectrometry (GC/MS) with a deuterium-labeled standard. The first method used a solid phase extractor (SPE) to isolate the analytes, followed by forming the heptafluorobutyryl (HFB) derivatives for measurement by GC/MS. The second method used another kind of SPE to isolate the analytes, followed by forming the N-trifluoroacetyl-1-prolyl chloride (TPC) derivatives for measurement by GC/MS. The RM consists of three levels of amphetamine, three levels of methamphetamine, and a blank. For amphetamine, the concentrations are 291, 558, and 1081 ng/mL of human urine. For methamphetamine, the concentrations are 311, 573, and 1137 ng/mL of human urine.</abstract><cop>Niles, IL</cop><pub>Oxford University Press</pub><pmid>8336490</pmid><doi>10.1093/jat/17.3.165</doi><tpages>6</tpages></addata></record> |
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subjects | Amphetamine Amphetamine - urine Biological and medical sciences Chloride Cooperation Drug addictions Freeze Drying Gas chromatography Gas Chromatography-Mass Spectrometry Humans Isomerism Mass spectroscopy Medical sciences Methamphetamine Methamphetamine - urine Reference Standards Solutions Toxicology Urine |
title | The Determination of Amphetamine and Methamphetamine in a Lyophilized Human Urine Reference Material |
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