Long‐Term GABA Treatment Elicits Supersensitivity of Quisqualate‐Preferring Metabotropic Glutamate Receptor in Cultured Rat Cerebellar Neurons

: In primary cultures of rat cerebellar granule neurons, GABA treatment (50 μM, 7 days) caused a withdrawal supersensitivity selective for the metabotropic glutamate receptors that mainly prefer l‐glutamate, quisqua‐ late and, to a lesser extent, kainate. The withdrawal supersensitivity was absent w...

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Veröffentlicht in:	Journal of neurochemistry 1993-08, Vol.61 (2), p.430-435
Hauptverfasser:	Yu, Onnfoh, Chuang, De‐Maw
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Baclofen - pharmacology Biological and medical sciences Carbachol - pharmacology Cells, Cultured Cerebellum - metabolism Dependence Drug Tolerance Fundamental and applied biological sciences. Psychology GABA receptors GABA-A Receptor Antagonists gamma-Aminobutyric Acid - pharmacology Glutamates - pharmacology Glutamic Acid Isolated neuron and nerve. Neuroglia Kainic Acid - pharmacology Metabotropic glutamate receptors N-Methylaspartate - pharmacology Neurons - metabolism Phosphoinositide hydrolysis Potassium Chloride - pharmacology Pyridazines - pharmacology Quisqualic Acid - metabolism Rats Rats, Sprague-Dawley Receptors, GABA-A - physiology Receptors, Glutamate - drug effects Receptors, Glutamate - metabolism Tolerance Vertebrates: nervous system and sense organs Withdrawal supersensitivity
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