Biochemical changes associated with the symptomatic human intervertebral disk
Significant changes in disk biochemistry were evident in the nuclei pulposi of 25 symptomatic disks that demonstrated abnormal diskography. Compared with the results from ten normal disk from young subjects (mean age, ten years) and from ten asymptomatic disks from adult patients (mean age, 33 years...
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| Veröffentlicht in: | Clinical orthopaedics and related research 1993-08 (293), p.372-377 |
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| container_title | Clinical orthopaedics and related research |
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| creator | KITANO, T ZERWEKH, J. E USUI, Y EDWARDS, M. L FLICKER, P. L MOONEY, V |
| description | Significant changes in disk biochemistry were evident in the nuclei pulposi of 25 symptomatic disks that demonstrated abnormal diskography. Compared with the results from ten normal disk from young subjects (mean age, ten years) and from ten asymptomatic disks from adult patients (mean age, 33 years), the symptomatic disks demonstrated significantly greater collagen content than the young and asymptomatic adult subjects, respectively. Significantly fewer total glycosaminoglycans (GAGs) and significantly less water content were also evident for the diseased disks. The mean pH of the nucleus pulposus from 23 patients was also significantly reduced for the symptomatic disks as compared with the mean pH measured for four asymptomatic adult subjects. Although significantly fewer total GAGs were observed for the symptomatic disks, there were no significant differences in the percent composition of hyaluronic acid (HA), chondroitin sulfate (CS), or keratan sulfate (KS) among the normal and symptomatic disks. Significant changes in disk biochemistry are associated with the symptomatic disk, and these changes could contribute to the development of the painful disk syndrome. |
| doi_str_mv | 10.1097/00003086-199308000-00050 |
| format | Article |
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Although significantly fewer total GAGs were observed for the symptomatic disks, there were no significant differences in the percent composition of hyaluronic acid (HA), chondroitin sulfate (CS), or keratan sulfate (KS) among the normal and symptomatic disks. Significant changes in disk biochemistry are associated with the symptomatic disk, and these changes could contribute to the development of the painful disk syndrome.</description><identifier>ISSN: 0009-921X</identifier><identifier>EISSN: 1528-1132</identifier><identifier>DOI: 10.1097/00003086-199308000-00050</identifier><identifier>PMID: 8339506</identifier><identifier>CODEN: CORTBR</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Biological and medical sciences ; Body Water ; Child ; Collagen - analysis ; Diseases of the osteoarticular system ; Diseases of the spine ; Glycosaminoglycans - analysis ; Humans ; Hydrogen-Ion Concentration ; Intervertebral Disc - chemistry ; Intervertebral Disc Displacement - metabolism ; Intervertebral Disc Displacement - surgery ; Lumbar Vertebrae ; Medical sciences ; Spinal Fusion</subject><ispartof>Clinical orthopaedics and related research, 1993-08 (293), p.372-377</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-2dbe9fa43fd379a5e6b7884da2826d05978a7ef55ccb8d92be72f92d0d774f993</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4870726$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8339506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KITANO, T</creatorcontrib><creatorcontrib>ZERWEKH, J. E</creatorcontrib><creatorcontrib>USUI, Y</creatorcontrib><creatorcontrib>EDWARDS, M. L</creatorcontrib><creatorcontrib>FLICKER, P. L</creatorcontrib><creatorcontrib>MOONEY, V</creatorcontrib><title>Biochemical changes associated with the symptomatic human intervertebral disk</title><title>Clinical orthopaedics and related research</title><addtitle>Clin Orthop Relat Res</addtitle><description>Significant changes in disk biochemistry were evident in the nuclei pulposi of 25 symptomatic disks that demonstrated abnormal diskography. Compared with the results from ten normal disk from young subjects (mean age, ten years) and from ten asymptomatic disks from adult patients (mean age, 33 years), the symptomatic disks demonstrated significantly greater collagen content than the young and asymptomatic adult subjects, respectively. Significantly fewer total glycosaminoglycans (GAGs) and significantly less water content were also evident for the diseased disks. The mean pH of the nucleus pulposus from 23 patients was also significantly reduced for the symptomatic disks as compared with the mean pH measured for four asymptomatic adult subjects. Although significantly fewer total GAGs were observed for the symptomatic disks, there were no significant differences in the percent composition of hyaluronic acid (HA), chondroitin sulfate (CS), or keratan sulfate (KS) among the normal and symptomatic disks. Significant changes in disk biochemistry are associated with the symptomatic disk, and these changes could contribute to the development of the painful disk syndrome.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Body Water</subject><subject>Child</subject><subject>Collagen - analysis</subject><subject>Diseases of the osteoarticular system</subject><subject>Diseases of the spine</subject><subject>Glycosaminoglycans - analysis</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Intervertebral Disc - chemistry</subject><subject>Intervertebral Disc Displacement - metabolism</subject><subject>Intervertebral Disc Displacement - surgery</subject><subject>Lumbar Vertebrae</subject><subject>Medical sciences</subject><subject>Spinal Fusion</subject><issn>0009-921X</issn><issn>1528-1132</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EKqXwCUhZIHYBP-LYXkLFSypiAxK7yLEnxNAkxXZB_XtcWrrFkjUa33tn5INQRvAFwUpc4nQYlmVOlEo1dXm6HO-hMeFU5oQwuo_G6U3lipLXQ3QUwvs6VHA6QiPJmOK4HKPHazeYFjpn9Dwzre7fIGQ6hME4HcFm3y62WWwhC6tuEYdOR2eydtnpPnN9BP8FPkLtU9i68HGMDho9D3CyrRP0cnvzPL3PZ093D9OrWW6YUjGntgbV6II1lgmlOZS1kLKwmkpaWsyVkFpAw7kxtbSK1iBoo6jFVoiiST-eoPPN3IUfPpcQYtW5YGA-1z0My1AJLrmgjP9rJGUpGOdlMsqN0fghBA9NtfCu035VEVytkVd_yKsd8uoXeYqebncs6w7sLrhlnPSzra5Dotx43RsXdrZCCixoyX4AxtSJxA</recordid><startdate>19930801</startdate><enddate>19930801</enddate><creator>KITANO, T</creator><creator>ZERWEKH, J. 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L ; MOONEY, V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-2dbe9fa43fd379a5e6b7884da2826d05978a7ef55ccb8d92be72f92d0d774f993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Body Water</topic><topic>Child</topic><topic>Collagen - analysis</topic><topic>Diseases of the osteoarticular system</topic><topic>Diseases of the spine</topic><topic>Glycosaminoglycans - analysis</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Intervertebral Disc - chemistry</topic><topic>Intervertebral Disc Displacement - metabolism</topic><topic>Intervertebral Disc Displacement - surgery</topic><topic>Lumbar Vertebrae</topic><topic>Medical sciences</topic><topic>Spinal Fusion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KITANO, T</creatorcontrib><creatorcontrib>ZERWEKH, J. E</creatorcontrib><creatorcontrib>USUI, Y</creatorcontrib><creatorcontrib>EDWARDS, M. L</creatorcontrib><creatorcontrib>FLICKER, P. L</creatorcontrib><creatorcontrib>MOONEY, V</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical orthopaedics and related research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KITANO, T</au><au>ZERWEKH, J. E</au><au>USUI, Y</au><au>EDWARDS, M. L</au><au>FLICKER, P. L</au><au>MOONEY, V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biochemical changes associated with the symptomatic human intervertebral disk</atitle><jtitle>Clinical orthopaedics and related research</jtitle><addtitle>Clin Orthop Relat Res</addtitle><date>1993-08-01</date><risdate>1993</risdate><issue>293</issue><spage>372</spage><epage>377</epage><pages>372-377</pages><issn>0009-921X</issn><eissn>1528-1132</eissn><coden>CORTBR</coden><abstract>Significant changes in disk biochemistry were evident in the nuclei pulposi of 25 symptomatic disks that demonstrated abnormal diskography. Compared with the results from ten normal disk from young subjects (mean age, ten years) and from ten asymptomatic disks from adult patients (mean age, 33 years), the symptomatic disks demonstrated significantly greater collagen content than the young and asymptomatic adult subjects, respectively. Significantly fewer total glycosaminoglycans (GAGs) and significantly less water content were also evident for the diseased disks. The mean pH of the nucleus pulposus from 23 patients was also significantly reduced for the symptomatic disks as compared with the mean pH measured for four asymptomatic adult subjects. Although significantly fewer total GAGs were observed for the symptomatic disks, there were no significant differences in the percent composition of hyaluronic acid (HA), chondroitin sulfate (CS), or keratan sulfate (KS) among the normal and symptomatic disks. Significant changes in disk biochemistry are associated with the symptomatic disk, and these changes could contribute to the development of the painful disk syndrome.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>8339506</pmid><doi>10.1097/00003086-199308000-00050</doi><tpages>6</tpages></addata></record> |
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| ispartof | Clinical orthopaedics and related research, 1993-08 (293), p.372-377 |
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| source | Journals@Ovid Ovid Autoload; MEDLINE |
| subjects | Adult Biological and medical sciences Body Water Child Collagen - analysis Diseases of the osteoarticular system Diseases of the spine Glycosaminoglycans - analysis Humans Hydrogen-Ion Concentration Intervertebral Disc - chemistry Intervertebral Disc Displacement - metabolism Intervertebral Disc Displacement - surgery Lumbar Vertebrae Medical sciences Spinal Fusion |
| title | Biochemical changes associated with the symptomatic human intervertebral disk |
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