Autoimmune polyendocrine failure - Type 1 (insulin-dependent) diabetes mellitus and hypothyroidism - after allogeneic bone marrow transplantation in a patient with lymphoblastic leukaemia
In this report we describe a patient who, after allogeneic bone marrow transplantation from her HLA-identical sister, developed polyendocrine failure in the form of Type 1 (insulin-dependent) diabetes mellitus and hypothyroidism. This was the result of the transfer of donor lymphoid cells which were...
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| Veröffentlicht in: | Diabetologia 1993-06, Vol.36 (6), p.541-546 |
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| container_title | Diabetologia |
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| creator | VIALETTES, B MARANINCHI, D SAN MARCO, M. P BIRG, F STOPPA, A. M MATTEI-ZEVACO, C THIVOLET, C HERMITTE, L VAGUE, P MERCIER, P |
| description | In this report we describe a patient who, after allogeneic bone marrow transplantation from her HLA-identical sister, developed polyendocrine failure in the form of Type 1 (insulin-dependent) diabetes mellitus and hypothyroidism. This was the result of the transfer of donor lymphoid cells which were activated by allogeneic bone marrow transplantation. The full chimerism of the recipient was demonstrated by restriction fragment length polymorphism analysis from nucleated blood cells and fibroblast DNA. During the 9-year follow-up, the donor developed hypothyroidism and signs of pre-Type 1 diabetes. This clinical observation resembles the adoptive transfer of diabetes observed in non-obese-diabetic mice and BB rats and confirms the role of immune processes in the pathogenesis of this disease. |
| doi_str_mv | 10.1007/bf02743271 |
| format | Article |
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P ; BIRG, F ; STOPPA, A. M ; MATTEI-ZEVACO, C ; THIVOLET, C ; HERMITTE, L ; VAGUE, P ; MERCIER, P</creator><creatorcontrib>VIALETTES, B ; MARANINCHI, D ; SAN MARCO, M. P ; BIRG, F ; STOPPA, A. M ; MATTEI-ZEVACO, C ; THIVOLET, C ; HERMITTE, L ; VAGUE, P ; MERCIER, P</creatorcontrib><description>In this report we describe a patient who, after allogeneic bone marrow transplantation from her HLA-identical sister, developed polyendocrine failure in the form of Type 1 (insulin-dependent) diabetes mellitus and hypothyroidism. This was the result of the transfer of donor lymphoid cells which were activated by allogeneic bone marrow transplantation. The full chimerism of the recipient was demonstrated by restriction fragment length polymorphism analysis from nucleated blood cells and fibroblast DNA. During the 9-year follow-up, the donor developed hypothyroidism and signs of pre-Type 1 diabetes. This clinical observation resembles the adoptive transfer of diabetes observed in non-obese-diabetic mice and BB rats and confirms the role of immune processes in the pathogenesis of this disease.</description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/bf02743271</identifier><identifier>PMID: 8101499</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adolescent ; Autoantibodies - blood ; Biological and medical sciences ; Blood Glucose - metabolism ; Bone Marrow Transplantation - immunology ; Chimera ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - etiology ; Diabetes Mellitus, Type 1 - immunology ; DNA - blood ; Endocrinopathies ; Female ; Follow-Up Studies ; General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes ; Humans ; Hypothyroidism - complications ; Hypothyroidism - etiology ; Hypothyroidism - immunology ; Immunoglobulin A - blood ; Immunoglobulin G - blood ; Immunoglobulin G - classification ; Islets of Langerhans - immunology ; Medical sciences ; Polymorphism, Restriction Fragment Length ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy ; Restriction Mapping ; Thyroid Gland - immunology ; Tissue Donors ; Transplantation, Homologous</subject><ispartof>Diabetologia, 1993-06, Vol.36 (6), p.541-546</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4753130$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8101499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VIALETTES, B</creatorcontrib><creatorcontrib>MARANINCHI, D</creatorcontrib><creatorcontrib>SAN MARCO, M. P</creatorcontrib><creatorcontrib>BIRG, F</creatorcontrib><creatorcontrib>STOPPA, A. M</creatorcontrib><creatorcontrib>MATTEI-ZEVACO, C</creatorcontrib><creatorcontrib>THIVOLET, C</creatorcontrib><creatorcontrib>HERMITTE, L</creatorcontrib><creatorcontrib>VAGUE, P</creatorcontrib><creatorcontrib>MERCIER, P</creatorcontrib><title>Autoimmune polyendocrine failure - Type 1 (insulin-dependent) diabetes mellitus and hypothyroidism - after allogeneic bone marrow transplantation in a patient with lymphoblastic leukaemia</title><title>Diabetologia</title><addtitle>Diabetologia</addtitle><description>In this report we describe a patient who, after allogeneic bone marrow transplantation from her HLA-identical sister, developed polyendocrine failure in the form of Type 1 (insulin-dependent) diabetes mellitus and hypothyroidism. This was the result of the transfer of donor lymphoid cells which were activated by allogeneic bone marrow transplantation. The full chimerism of the recipient was demonstrated by restriction fragment length polymorphism analysis from nucleated blood cells and fibroblast DNA. During the 9-year follow-up, the donor developed hypothyroidism and signs of pre-Type 1 diabetes. This clinical observation resembles the adoptive transfer of diabetes observed in non-obese-diabetic mice and BB rats and confirms the role of immune processes in the pathogenesis of this disease.</description><subject>Adolescent</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Bone Marrow Transplantation - immunology</subject><subject>Chimera</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 1 - etiology</subject><subject>Diabetes Mellitus, Type 1 - immunology</subject><subject>DNA - blood</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes</subject><subject>Humans</subject><subject>Hypothyroidism - complications</subject><subject>Hypothyroidism - etiology</subject><subject>Hypothyroidism - immunology</subject><subject>Immunoglobulin A - blood</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G - classification</subject><subject>Islets of Langerhans - immunology</subject><subject>Medical sciences</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy</subject><subject>Restriction Mapping</subject><subject>Thyroid Gland - immunology</subject><subject>Tissue Donors</subject><subject>Transplantation, Homologous</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UE2LFTEQDKKsb1cv3oUcZFkPo_mazMxxWfyCBS8reHv0JD2-aD7GJMMyv80_Z8CHp66mqquoJuQVZ-84Y8P7eWFiUFIM_Ak58AY6psT4lBwY46Ljo_7-nFyW8pMxJnulL8jFyBlX03Qgf263mlwIW0S6Jr9jtMlk17YFnN8y0o4-7CtSTm9cLJt3sbO4NhnG-pZaBzNWLDSg965uhUK09LSvqZ72nJx1JTQHWCpmCt6nHxjRGTqnlhAg5_RIa4ZYVg-xQnUpUhcp0LXhlkAfXT1Rv4f1lGYPpbZbj9svwODgBXm2gC_48jyvyLePHx7uPnf3Xz99ubu97yKfdO0AQIgZDINhUhIYqmHkCowGK4QBNchRS6as0IsYDdf9LK0dJz4JZByllVfk-p_vmtPvDUs9BldMKwwR01aOQz_2ehK6CV-fhdsc0B7X7FrH_Xj-duPfnHkoBvzSihtX_svU0EsumfwLd26STw</recordid><startdate>19930601</startdate><enddate>19930601</enddate><creator>VIALETTES, B</creator><creator>MARANINCHI, D</creator><creator>SAN MARCO, M. P</creator><creator>BIRG, F</creator><creator>STOPPA, A. M</creator><creator>MATTEI-ZEVACO, C</creator><creator>THIVOLET, C</creator><creator>HERMITTE, L</creator><creator>VAGUE, P</creator><creator>MERCIER, P</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19930601</creationdate><title>Autoimmune polyendocrine failure - Type 1 (insulin-dependent) diabetes mellitus and hypothyroidism - after allogeneic bone marrow transplantation in a patient with lymphoblastic leukaemia</title><author>VIALETTES, B ; MARANINCHI, D ; SAN MARCO, M. P ; BIRG, F ; STOPPA, A. M ; MATTEI-ZEVACO, C ; THIVOLET, C ; HERMITTE, L ; VAGUE, P ; MERCIER, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-n196t-aaa22bac0a7943a0e47814ac6ad22ca47386304d26f28c165b3dd89192e01e3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adolescent</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Bone Marrow Transplantation - immunology</topic><topic>Chimera</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Diabetes Mellitus, Type 1 - etiology</topic><topic>Diabetes Mellitus, Type 1 - immunology</topic><topic>DNA - blood</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes</topic><topic>Humans</topic><topic>Hypothyroidism - complications</topic><topic>Hypothyroidism - etiology</topic><topic>Hypothyroidism - immunology</topic><topic>Immunoglobulin A - blood</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin G - classification</topic><topic>Islets of Langerhans - immunology</topic><topic>Medical sciences</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy</topic><topic>Restriction Mapping</topic><topic>Thyroid Gland - immunology</topic><topic>Tissue Donors</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VIALETTES, B</creatorcontrib><creatorcontrib>MARANINCHI, D</creatorcontrib><creatorcontrib>SAN MARCO, M. P</creatorcontrib><creatorcontrib>BIRG, F</creatorcontrib><creatorcontrib>STOPPA, A. M</creatorcontrib><creatorcontrib>MATTEI-ZEVACO, C</creatorcontrib><creatorcontrib>THIVOLET, C</creatorcontrib><creatorcontrib>HERMITTE, L</creatorcontrib><creatorcontrib>VAGUE, P</creatorcontrib><creatorcontrib>MERCIER, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VIALETTES, B</au><au>MARANINCHI, D</au><au>SAN MARCO, M. P</au><au>BIRG, F</au><au>STOPPA, A. 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The full chimerism of the recipient was demonstrated by restriction fragment length polymorphism analysis from nucleated blood cells and fibroblast DNA. During the 9-year follow-up, the donor developed hypothyroidism and signs of pre-Type 1 diabetes. This clinical observation resembles the adoptive transfer of diabetes observed in non-obese-diabetic mice and BB rats and confirms the role of immune processes in the pathogenesis of this disease.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>8101499</pmid><doi>10.1007/bf02743271</doi><tpages>6</tpages></addata></record> |
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| ispartof | Diabetologia, 1993-06, Vol.36 (6), p.541-546 |
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| subjects | Adolescent Autoantibodies - blood Biological and medical sciences Blood Glucose - metabolism Bone Marrow Transplantation - immunology Chimera Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - etiology Diabetes Mellitus, Type 1 - immunology DNA - blood Endocrinopathies Female Follow-Up Studies General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes Humans Hypothyroidism - complications Hypothyroidism - etiology Hypothyroidism - immunology Immunoglobulin A - blood Immunoglobulin G - blood Immunoglobulin G - classification Islets of Langerhans - immunology Medical sciences Polymorphism, Restriction Fragment Length Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy Restriction Mapping Thyroid Gland - immunology Tissue Donors Transplantation, Homologous |
| title | Autoimmune polyendocrine failure - Type 1 (insulin-dependent) diabetes mellitus and hypothyroidism - after allogeneic bone marrow transplantation in a patient with lymphoblastic leukaemia |
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