Therapy of mouse mammary carcinomas with vincristine and doxorubicin encapsulated in sterically stabilized liposomes
This study tested the therapeutic effects of vincristine sulfate and doxorubicin hydrochloride, each drug in 2 different formulations: (i) as a solution in saline, and (ii) encapsulated in sterically stabilized, long‐circulating liposomes composed of hydroge‐natedsoy‐phosphatidylcholine/cholesterol/...
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| Veröffentlicht in: | International journal of cancer 1993-07, Vol.54 (6), p.959-964 |
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| container_title | International journal of cancer |
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| creator | Vaage, Jan Donovan, Dorothy Mayhew, Eric Uster, Paul Woodle, Martin |
| description | This study tested the therapeutic effects of vincristine sulfate and doxorubicin hydrochloride, each drug in 2 different formulations: (i) as a solution in saline, and (ii) encapsulated in sterically stabilized, long‐circulating liposomes composed of hydroge‐natedsoy‐phosphatidylcholine/cholesterol/polyethylene‐glycer‐ol‐distearoyl‐ phosphatidylethanolamine. The 4 drug preparations were used to treat s.c. implants of the mouse mammary carcinoma MC2. The drugs were given by i.v. injection over 15 to 18 days, starting 3 days after tumor implantation. The single‐drug therapeutic effects of vincristine (S‐VCR) and doxorubicin (Doxil) in liposomes were compared, and the 2 preparations were also tested in alternate and in simultaneous combinations. These new liposome formulations of vincristine and doxorubicin were significantly more effective than the free drugs in curing the mice. Alternate, semi‐weekly injection of both drugs gave the best therapeutic effect. Prolonged circulation time with increased accumulation in tumors are considered likely reasons for the improved therapeutic efficacy of both drugs when encapsulated in these liposomes. |
| doi_str_mv | 10.1002/ijc.2910540616 |
| format | Article |
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The 4 drug preparations were used to treat s.c. implants of the mouse mammary carcinoma MC2. The drugs were given by i.v. injection over 15 to 18 days, starting 3 days after tumor implantation. The single‐drug therapeutic effects of vincristine (S‐VCR) and doxorubicin (Doxil) in liposomes were compared, and the 2 preparations were also tested in alternate and in simultaneous combinations. These new liposome formulations of vincristine and doxorubicin were significantly more effective than the free drugs in curing the mice. Alternate, semi‐weekly injection of both drugs gave the best therapeutic effect. 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Drug treatments ; Vincristine - administration & dosage</subject><ispartof>International journal of cancer, 1993-07, Vol.54 (6), p.959-964</ispartof><rights>Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3696-531cf2b7b4a97ea84b66a5b220c5aac3b1ce75194a1904d3379ea31aa70d24af3</citedby><cites>FETCH-LOGICAL-c3696-531cf2b7b4a97ea84b66a5b220c5aac3b1ce75194a1904d3379ea31aa70d24af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.2910540616$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.2910540616$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4042665$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8335404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vaage, Jan</creatorcontrib><creatorcontrib>Donovan, Dorothy</creatorcontrib><creatorcontrib>Mayhew, Eric</creatorcontrib><creatorcontrib>Uster, Paul</creatorcontrib><creatorcontrib>Woodle, Martin</creatorcontrib><title>Therapy of mouse mammary carcinomas with vincristine and doxorubicin encapsulated in sterically stabilized liposomes</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>This study tested the therapeutic effects of vincristine sulfate and doxorubicin hydrochloride, each drug in 2 different formulations: (i) as a solution in saline, and (ii) encapsulated in sterically stabilized, long‐circulating liposomes composed of hydroge‐natedsoy‐phosphatidylcholine/cholesterol/polyethylene‐glycer‐ol‐distearoyl‐ phosphatidylethanolamine. The 4 drug preparations were used to treat s.c. implants of the mouse mammary carcinoma MC2. The drugs were given by i.v. injection over 15 to 18 days, starting 3 days after tumor implantation. The single‐drug therapeutic effects of vincristine (S‐VCR) and doxorubicin (Doxil) in liposomes were compared, and the 2 preparations were also tested in alternate and in simultaneous combinations. These new liposome formulations of vincristine and doxorubicin were significantly more effective than the free drugs in curing the mice. Alternate, semi‐weekly injection of both drugs gave the best therapeutic effect. Prolonged circulation time with increased accumulation in tumors are considered likely reasons for the improved therapeutic efficacy of both drugs when encapsulated in these liposomes.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Doxorubicin - administration & dosage</subject><subject>Drug Carriers</subject><subject>Female</subject><subject>Liposomes</subject><subject>Mammary Neoplasms, Experimental - drug therapy</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Pharmacology. Drug treatments</subject><subject>Vincristine - administration & dosage</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EgvKxsiF5QGwpdhw7zYgqPlWJBebo4lyEkRMHO6GUX4-rVoWNyWe9z519DyHnnE05Y-m1edfTtOBMZkxxtUcmnBV5wlIu98kkAizJuVBH5DiEd8Y4lyw7JIczIWJDNiHDyxt66FfUNbR1Y0DaQtuCX1ENXpvOtRDo0gxv9NN02pswmA4pdDWt3ZfzY2UiRLHT0IfRwoA1jfcwoDcarF3FEipjzXcMrOldcC2GU3LQgA14tj1PyOvd7cv8IVk83z_ObxaJFqpQiRRcN2mVVxkUOcIsq5QCWaUp0xJAi4przCUvMuAFy2oh8gJBcICc1WkGjTghV5u5vXcfI4ahbE3QaC10GHctczmTSs5YBKcbUHsXgsem7L1ZWyg5K9eay6i5_NUcGy62k8eqxXqHb73G_HKbQ4geGg-dNmGHRSRVSkas2GBLY3H1z6Pl49P8zxd-AFl9mK8</recordid><startdate>19930730</startdate><enddate>19930730</enddate><creator>Vaage, Jan</creator><creator>Donovan, Dorothy</creator><creator>Mayhew, Eric</creator><creator>Uster, Paul</creator><creator>Woodle, Martin</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930730</creationdate><title>Therapy of mouse mammary carcinomas with vincristine and doxorubicin encapsulated in sterically stabilized liposomes</title><author>Vaage, Jan ; Donovan, Dorothy ; Mayhew, Eric ; Uster, Paul ; Woodle, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3696-531cf2b7b4a97ea84b66a5b220c5aac3b1ce75194a1904d3379ea31aa70d24af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>Doxorubicin - administration & dosage</topic><topic>Drug Carriers</topic><topic>Female</topic><topic>Liposomes</topic><topic>Mammary Neoplasms, Experimental - drug therapy</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Pharmacology. Drug treatments</topic><topic>Vincristine - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vaage, Jan</creatorcontrib><creatorcontrib>Donovan, Dorothy</creatorcontrib><creatorcontrib>Mayhew, Eric</creatorcontrib><creatorcontrib>Uster, Paul</creatorcontrib><creatorcontrib>Woodle, Martin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vaage, Jan</au><au>Donovan, Dorothy</au><au>Mayhew, Eric</au><au>Uster, Paul</au><au>Woodle, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapy of mouse mammary carcinomas with vincristine and doxorubicin encapsulated in sterically stabilized liposomes</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>1993-07-30</date><risdate>1993</risdate><volume>54</volume><issue>6</issue><spage>959</spage><epage>964</epage><pages>959-964</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><abstract>This study tested the therapeutic effects of vincristine sulfate and doxorubicin hydrochloride, each drug in 2 different formulations: (i) as a solution in saline, and (ii) encapsulated in sterically stabilized, long‐circulating liposomes composed of hydroge‐natedsoy‐phosphatidylcholine/cholesterol/polyethylene‐glycer‐ol‐distearoyl‐ phosphatidylethanolamine. The 4 drug preparations were used to treat s.c. implants of the mouse mammary carcinoma MC2. The drugs were given by i.v. injection over 15 to 18 days, starting 3 days after tumor implantation. The single‐drug therapeutic effects of vincristine (S‐VCR) and doxorubicin (Doxil) in liposomes were compared, and the 2 preparations were also tested in alternate and in simultaneous combinations. These new liposome formulations of vincristine and doxorubicin were significantly more effective than the free drugs in curing the mice. Alternate, semi‐weekly injection of both drugs gave the best therapeutic effect. Prolonged circulation time with increased accumulation in tumors are considered likely reasons for the improved therapeutic efficacy of both drugs when encapsulated in these liposomes.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8335404</pmid><doi>10.1002/ijc.2910540616</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-7136 |
| ispartof | International journal of cancer, 1993-07, Vol.54 (6), p.959-964 |
| issn | 0020-7136 1097-0215 |
| language | eng |
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| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Animals Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Chemotherapy Doxorubicin - administration & dosage Drug Carriers Female Liposomes Mammary Neoplasms, Experimental - drug therapy Medical sciences Mice Mice, Inbred C3H Pharmacology. Drug treatments Vincristine - administration & dosage |
| title | Therapy of mouse mammary carcinomas with vincristine and doxorubicin encapsulated in sterically stabilized liposomes |
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