The prostaglandin-analogue-9-deoxo-16,16-dimethyl-9-methylene-PGE2 inhibits the antidiuretic effect of vasopressin (AVP) in the conscious sheep
The effects of intravenous infusions of the stable prostaglandin analogue 9-deoxo-16,16-dimethyl-9-methylene-PGE2 (9-methylene-PGE2) in a dosage of 10 or 24 micrograms/min were studied in the consicious euhydrated, dehydrated, and hyperhydrated with the simultaneous administration of exogenous argin...
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| Veröffentlicht in: | Pflügers Archiv 1984-12, Vol.402 (4), p.360-363 |
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| creator | CHRISTENSEN, N.-J BYGDEMAN, M GREEN, K JONASSON, H RUNDGREN, M WALLIN, C.-J VESTERQVIST, O LEKSELL, L. G |
| description | The effects of intravenous infusions of the stable prostaglandin analogue 9-deoxo-16,16-dimethyl-9-methylene-PGE2 (9-methylene-PGE2) in a dosage of 10 or 24 micrograms/min were studied in the consicious euhydrated, dehydrated, and hyperhydrated with the simultaneous administration of exogenous arginine vasopressin (AVP), sheep. The infusions decreased urine osmolality and increased urine flow and renal free water clearance. The results indicate that 9-methylene-PGE2 exhibits its diuretic effect by antagonizing the antidiuretic action of AVP. In the hyperhydrated sheep receiving AVP the syndrome of inappropriate antidiuretic hormone release (SIADH) was simulated. As the prostaglandin analogue effectively blocked the antidiuretic effect of the AVP-administration it appears that 9-methylene-PGE2 may play a future role as a diuretic agent, especially in conditions characterized by water retention and dilutional hyponatremia such as SIADH. |
| doi_str_mv | 10.1007/BF00583936 |
| format | Article |
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As the prostaglandin analogue effectively blocked the antidiuretic effect of the AVP-administration it appears that 9-methylene-PGE2 may play a future role as a diuretic agent, especially in conditions characterized by water retention and dilutional hyponatremia such as SIADH.</description><identifier>ISSN: 0031-6768</identifier><identifier>EISSN: 1432-2013</identifier><identifier>DOI: 10.1007/BF00583936</identifier><identifier>PMID: 6522243</identifier><identifier>CODEN: PFLABK</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>16,16-Dimethylprostaglandin E2 - analogs & derivatives ; 16,16-Dimethylprostaglandin E2 - pharmacology ; Animals ; Arginine Vasopressin - antagonists & inhibitors ; Biological and medical sciences ; Body Temperature Regulation - drug effects ; Body Water - metabolism ; Consciousness ; Dehydration - physiopathology ; Diuresis - drug effects ; Female ; Fundamental and applied biological sciences. Psychology ; General aspects. 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Adaptive reactions ; Prostaglandins - pharmacology ; Prostaglandins E, Synthetic - pharmacology ; Sheep ; Sodium - urine ; Vertebrates: endocrinology</subject><ispartof>Pflügers Archiv, 1984-12, Vol.402 (4), p.360-363</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-c6a8f0e26463d90ad05f119f2328b3d653ba59ca1b529840bd74827e825ec9a3</citedby><cites>FETCH-LOGICAL-c311t-c6a8f0e26463d90ad05f119f2328b3d653ba59ca1b529840bd74827e825ec9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9255826$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6522243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHRISTENSEN, N.-J</creatorcontrib><creatorcontrib>BYGDEMAN, M</creatorcontrib><creatorcontrib>GREEN, K</creatorcontrib><creatorcontrib>JONASSON, H</creatorcontrib><creatorcontrib>RUNDGREN, M</creatorcontrib><creatorcontrib>WALLIN, C.-J</creatorcontrib><creatorcontrib>VESTERQVIST, O</creatorcontrib><creatorcontrib>LEKSELL, L. G</creatorcontrib><title>The prostaglandin-analogue-9-deoxo-16,16-dimethyl-9-methylene-PGE2 inhibits the antidiuretic effect of vasopressin (AVP) in the conscious sheep</title><title>Pflügers Archiv</title><addtitle>Pflugers Arch</addtitle><description>The effects of intravenous infusions of the stable prostaglandin analogue 9-deoxo-16,16-dimethyl-9-methylene-PGE2 (9-methylene-PGE2) in a dosage of 10 or 24 micrograms/min were studied in the consicious euhydrated, dehydrated, and hyperhydrated with the simultaneous administration of exogenous arginine vasopressin (AVP), sheep. The infusions decreased urine osmolality and increased urine flow and renal free water clearance. The results indicate that 9-methylene-PGE2 exhibits its diuretic effect by antagonizing the antidiuretic action of AVP. In the hyperhydrated sheep receiving AVP the syndrome of inappropriate antidiuretic hormone release (SIADH) was simulated. As the prostaglandin analogue effectively blocked the antidiuretic effect of the AVP-administration it appears that 9-methylene-PGE2 may play a future role as a diuretic agent, especially in conditions characterized by water retention and dilutional hyponatremia such as SIADH.</description><subject>16,16-Dimethylprostaglandin E2 - analogs & derivatives</subject><subject>16,16-Dimethylprostaglandin E2 - pharmacology</subject><subject>Animals</subject><subject>Arginine Vasopressin - antagonists & inhibitors</subject><subject>Biological and medical sciences</subject><subject>Body Temperature Regulation - drug effects</subject><subject>Body Water - metabolism</subject><subject>Consciousness</subject><subject>Dehydration - physiopathology</subject><subject>Diuresis - drug effects</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects. Hormone interactions. Hormone actions on several organ systems. Adaptive reactions</subject><subject>Prostaglandins - pharmacology</subject><subject>Prostaglandins E, Synthetic - pharmacology</subject><subject>Sheep</subject><subject>Sodium - urine</subject><subject>Vertebrates: endocrinology</subject><issn>0031-6768</issn><issn>1432-2013</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LJDEQhoOsuOPHxftCHxZxxWg-OunkqOIXCHoYvDbppOJk6UnPdtKL_gr_8sadQU8pUk-9VD0IHVJyRglpzi9vCBGKay630IzWnGFGKP-GZoRwimUj1Xe0m9JvQgirFdtBO1Iwxmo-Q-_zBVSrcUjZvPQmuhCxiaYfXibAGjsYXgdM5SmV2IUl5MVbX77XBUTAT7fXrApxEbqQU5VLlok5uDCNkIOtwHuwuRp89dekYTVCSiFWxxfPT7_K1H_eDjHZMEypSguA1T7a9qZPcLB599D85np-dYcfHm_vry4esOWUZmylUZ4Ak7XkThPjiPCUas84Ux13UvDOCG0N7QTTqiada8rhDSgmwGrD99DROrac_meClNtlSBb6ogDKLm0jlOBayQKerEFbHKURfLsaw9KMby0l7Yf89kt-gX9sUqduCe4T3dgu_Z-bvknW9H400Yb0iWkmhGKS_wOi_4tx</recordid><startdate>198412</startdate><enddate>198412</enddate><creator>CHRISTENSEN, N.-J</creator><creator>BYGDEMAN, M</creator><creator>GREEN, K</creator><creator>JONASSON, H</creator><creator>RUNDGREN, M</creator><creator>WALLIN, C.-J</creator><creator>VESTERQVIST, O</creator><creator>LEKSELL, L. 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The results indicate that 9-methylene-PGE2 exhibits its diuretic effect by antagonizing the antidiuretic action of AVP. In the hyperhydrated sheep receiving AVP the syndrome of inappropriate antidiuretic hormone release (SIADH) was simulated. As the prostaglandin analogue effectively blocked the antidiuretic effect of the AVP-administration it appears that 9-methylene-PGE2 may play a future role as a diuretic agent, especially in conditions characterized by water retention and dilutional hyponatremia such as SIADH.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>6522243</pmid><doi>10.1007/BF00583936</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; SpringerNature Journals |
| subjects | 16,16-Dimethylprostaglandin E2 - analogs & derivatives 16,16-Dimethylprostaglandin E2 - pharmacology Animals Arginine Vasopressin - antagonists & inhibitors Biological and medical sciences Body Temperature Regulation - drug effects Body Water - metabolism Consciousness Dehydration - physiopathology Diuresis - drug effects Female Fundamental and applied biological sciences. Psychology General aspects. Hormone interactions. Hormone actions on several organ systems. Adaptive reactions Prostaglandins - pharmacology Prostaglandins E, Synthetic - pharmacology Sheep Sodium - urine Vertebrates: endocrinology |
| title | The prostaglandin-analogue-9-deoxo-16,16-dimethyl-9-methylene-PGE2 inhibits the antidiuretic effect of vasopressin (AVP) in the conscious sheep |
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