Pneumocystis carinii induces the release of arachidonic acid and its metabolites from alveolar macrophages

Pneumocystis carinii is an opportunistic organism that causes severe lung injury in immunocompromised hosts. Macrophage responses to P. carinii are poorly defined. Arachidonic acid (AA) and its metabolites are potent mediators of inflammation and have been implicated in host response to microorganis...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 1993-07, Vol.9 (1), p.73-81
Hauptverfasser:	Castro, M, Morgenthaler, T I, Hoffman, O A, Standing, J E, Rohrbach, M S, Limper, A H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acids - metabolism Dinoprostone - biosynthesis Female Glucans - metabolism Lectins, C-Type Leukotriene B4 - biosynthesis Macrophages, Alveolar - immunology Macrophages, Alveolar - metabolism Mannose - metabolism Mannose-Binding Lectins Opsonin Proteins - metabolism Phagocytosis Pneumocystis - immunology Pneumonia, Pneumocystis - metabolism Rabbits Rats Rats, Sprague-Dawley Receptors, Cell Surface - metabolism Receptors, Immunologic - metabolism Solubility
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