Cyclosporine and Islet Mass—Implications for Islet Transplantation

Cyclosporine (CsA) is an inhibitor of ornithine decarboxylase (ODC), a key enzymatic step in cell proliferation. The purpose of this study was to determine the effect of CsA on islet cell mass. Partial obstruction (PDO) of the hamster pancreas is an established model of islet cell differentiation an...

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Veröffentlicht in:	The Journal of surgical research 1993-04, Vol.54 (4), p.375-380
Hauptverfasser:	Metrakos, P., Hornby, L., Rosenberg, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Differentiation - drug effects Cell Division - drug effects Cricetinae Cyclosporine - pharmacology Female Graft Survival Immunomodulators Islets of Langerhans - cytology Islets of Langerhans - drug effects Islets of Langerhans Transplantation Medical sciences Mesocricetus Organ Size Ornithine Decarboxylase - metabolism Pancreas - enzymology Pharmacology. Drug treatments
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