Influence of the cGMP analog 8-PCPT-cGMP on agonist-induced increases in cytosolic ionized Ca2+ and on aggregation of human platelets

The present study was undertaken to compare inhibitory effects of the cGMP analog 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate (8-PCPT-cGMP) on increases in cytosolic ionized Ca2+ and on aggregation in human platelets induced via diverse agonists. Fura-2-loaded and gel-filter...

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Veröffentlicht in:	European journal of pharmacology 1993-05, Vol.245 (3), p.281-284
Hauptverfasser:	MENSHIKOV, M. YU, IVANOVA, K, SCHAEFER, M, DRUMMER, C, GERZER, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Biological and medical sciences Blood Platelets - drug effects Blood Platelets - metabolism Blood. Blood coagulation. Reticuloendothelial system Calcium - metabolism Collagen - pharmacology Cyclic GMP - analogs & derivatives Cyclic GMP - pharmacology Cytosol - metabolism Female Humans Male Medical sciences Pharmacology. Drug treatments Platelet Aggregation - drug effects Thionucleotides - pharmacology Thrombin - pharmacology
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