Effect of systemically administered caerulein on dopamine metabolism in rat brain
The effect of caerulein, a cholecystokinin-like peptide, on the dopamine (DA) system was examined in rat brain. Caerulein, when tested in vitro, had no significant influence on either D-1 or D-2 DA receptors. A single injection of caerulein (400 μg/kg, i.p.) reduced both homovanillic acid (HVA) and...
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| Veröffentlicht in: | Brain research 1984-12, Vol.324 (1), p.195-199 |
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| container_title | Brain research |
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| creator | Matsumoto, Takashi Nakahara, Tatsuo Uchimura, Hideyuki Hirano, Makoto Yokoo, Hideyasu Nakamura, Kaoru Oomagari, Kiyoshi |
| description | The effect of caerulein, a cholecystokinin-like peptide, on the dopamine (DA) system was examined in rat brain. Caerulein, when tested in vitro, had no significant influence on either D-1 or D-2 DA receptors. A single injection of caerulein (400 μg/kg, i.p.) reduced both homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in the striatum. No significant change in DA metabolites was found in the other 7 areas (polar and medial fields of prefrontal cortex, anterior cingulate cortex, nucleus accumbens, tuberculum olfactorium, septum and amygdala). After repeated injections of caerulein (200 μg/kg, i.p., daily for 5 days), the decreases in striatal HVA and DOPAC had disappeared, while the amount of HVA had increased in the nucleus accumbens. These results suggest that peripherally administered caerulein modulates the nigrostriatal and mesolimbic DA neuron systems in the different modes of action. |
| doi_str_mv | 10.1016/0006-8993(84)90643-7 |
| format | Article |
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Caerulein, when tested in vitro, had no significant influence on either D-1 or D-2 DA receptors. A single injection of caerulein (400 μg/kg, i.p.) reduced both homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in the striatum. No significant change in DA metabolites was found in the other 7 areas (polar and medial fields of prefrontal cortex, anterior cingulate cortex, nucleus accumbens, tuberculum olfactorium, septum and amygdala). After repeated injections of caerulein (200 μg/kg, i.p., daily for 5 days), the decreases in striatal HVA and DOPAC had disappeared, while the amount of HVA had increased in the nucleus accumbens. These results suggest that peripherally administered caerulein modulates the nigrostriatal and mesolimbic DA neuron systems in the different modes of action.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(84)90643-7</identifier><identifier>PMID: 6518389</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>3,4-dihydroxyphenylacetic acid ; 3,4-Dihydroxyphenylacetic Acid - analysis ; [ 3H]spiperone binding ; Animals ; Biological and medical sciences ; Brain - metabolism ; caerulein ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Cerebral Cortex - analysis ; Ceruletide - pharmacology ; Corpus Striatum - analysis ; Dopamine - metabolism ; dopamine neuron ; dopamine-sensitive adenylate cyclase ; Fundamental and applied biological sciences. Psychology ; homovanillic acid ; Homovanillic Acid - analysis ; Limbic System - analysis ; Male ; Mesencephalon - analysis ; nucleus accumbens ; Rats ; Rats, Inbred Strains ; striatum ; Substantia Nigra - analysis ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1984-12, Vol.324 (1), p.195-199</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-bbb7cafc9d86eb0804c1b48e89c8ad5f8a0c626e443b26f5eba0f9f1dd7085bb3</citedby><cites>FETCH-LOGICAL-c398t-bbb7cafc9d86eb0804c1b48e89c8ad5f8a0c626e443b26f5eba0f9f1dd7085bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006899384906437$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9015408$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6518389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsumoto, Takashi</creatorcontrib><creatorcontrib>Nakahara, Tatsuo</creatorcontrib><creatorcontrib>Uchimura, Hideyuki</creatorcontrib><creatorcontrib>Hirano, Makoto</creatorcontrib><creatorcontrib>Yokoo, Hideyasu</creatorcontrib><creatorcontrib>Nakamura, Kaoru</creatorcontrib><creatorcontrib>Oomagari, Kiyoshi</creatorcontrib><title>Effect of systemically administered caerulein on dopamine metabolism in rat brain</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The effect of caerulein, a cholecystokinin-like peptide, on the dopamine (DA) system was examined in rat brain. Caerulein, when tested in vitro, had no significant influence on either D-1 or D-2 DA receptors. A single injection of caerulein (400 μg/kg, i.p.) reduced both homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in the striatum. No significant change in DA metabolites was found in the other 7 areas (polar and medial fields of prefrontal cortex, anterior cingulate cortex, nucleus accumbens, tuberculum olfactorium, septum and amygdala). After repeated injections of caerulein (200 μg/kg, i.p., daily for 5 days), the decreases in striatal HVA and DOPAC had disappeared, while the amount of HVA had increased in the nucleus accumbens. These results suggest that peripherally administered caerulein modulates the nigrostriatal and mesolimbic DA neuron systems in the different modes of action.</description><subject>3,4-dihydroxyphenylacetic acid</subject><subject>3,4-Dihydroxyphenylacetic Acid - analysis</subject><subject>[ 3H]spiperone binding</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>caerulein</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Cerebral Cortex - analysis</subject><subject>Ceruletide - pharmacology</subject><subject>Corpus Striatum - analysis</subject><subject>Dopamine - metabolism</subject><subject>dopamine neuron</subject><subject>dopamine-sensitive adenylate cyclase</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>homovanillic acid</subject><subject>Homovanillic Acid - analysis</subject><subject>Limbic System - analysis</subject><subject>Male</subject><subject>Mesencephalon - analysis</subject><subject>nucleus accumbens</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>striatum</subject><subject>Substantia Nigra - analysis</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctqHDEQRUVIsMdO_iABLYKxF-2UWmq1tAkE40fAEAzOWuhRAoV-jKWewPy9NZ5hlsmqUN1TRXFEyGcG1wyY_AYAslFa80slrjRIwZv-HVkx1beNbAW8J6sjckrOSvlTn5xrOCEnsmOKK70iT7cxol_oHGnZlgXH5O0wbKkNY5pSbWQM1FvMmwHTROeJhnlta4Z0xMW6eUhlpDXJdqEu2zR9JB-iHQp-OtRz8vvu9vnmoXn8df_z5sdj47lWS-Oc672NXgcl0YEC4ZkTCpX2yoYuKgtethKF4K6VsUNnIerIQuhBdc7xc3Kx37vO88sGy2LGVDwOg51w3hTTd0po6Ph_QSZY3_NWVlDsQZ_nUjJGs85ptHlrGJidcrPzaXY-jRLmTbnp69iXw_6NGzEchw6Oa_71kNtS5cZsJ5_KEdPAOgGqYt_3GFZpfxNmU3zCyWNIuf6QCXP69x2v7NueMQ</recordid><startdate>19841217</startdate><enddate>19841217</enddate><creator>Matsumoto, Takashi</creator><creator>Nakahara, Tatsuo</creator><creator>Uchimura, Hideyuki</creator><creator>Hirano, Makoto</creator><creator>Yokoo, Hideyasu</creator><creator>Nakamura, Kaoru</creator><creator>Oomagari, Kiyoshi</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19841217</creationdate><title>Effect of systemically administered caerulein on dopamine metabolism in rat brain</title><author>Matsumoto, Takashi ; Nakahara, Tatsuo ; Uchimura, Hideyuki ; Hirano, Makoto ; Yokoo, Hideyasu ; Nakamura, Kaoru ; Oomagari, Kiyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-bbb7cafc9d86eb0804c1b48e89c8ad5f8a0c626e443b26f5eba0f9f1dd7085bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>3,4-dihydroxyphenylacetic acid</topic><topic>3,4-Dihydroxyphenylacetic Acid - analysis</topic><topic>[ 3H]spiperone binding</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>caerulein</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Cerebral Cortex - analysis</topic><topic>Ceruletide - pharmacology</topic><topic>Corpus Striatum - analysis</topic><topic>Dopamine - metabolism</topic><topic>dopamine neuron</topic><topic>dopamine-sensitive adenylate cyclase</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>homovanillic acid</topic><topic>Homovanillic Acid - analysis</topic><topic>Limbic System - analysis</topic><topic>Male</topic><topic>Mesencephalon - analysis</topic><topic>nucleus accumbens</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>striatum</topic><topic>Substantia Nigra - analysis</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsumoto, Takashi</creatorcontrib><creatorcontrib>Nakahara, Tatsuo</creatorcontrib><creatorcontrib>Uchimura, Hideyuki</creatorcontrib><creatorcontrib>Hirano, Makoto</creatorcontrib><creatorcontrib>Yokoo, Hideyasu</creatorcontrib><creatorcontrib>Nakamura, Kaoru</creatorcontrib><creatorcontrib>Oomagari, Kiyoshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsumoto, Takashi</au><au>Nakahara, Tatsuo</au><au>Uchimura, Hideyuki</au><au>Hirano, Makoto</au><au>Yokoo, Hideyasu</au><au>Nakamura, Kaoru</au><au>Oomagari, Kiyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of systemically administered caerulein on dopamine metabolism in rat brain</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1984-12-17</date><risdate>1984</risdate><volume>324</volume><issue>1</issue><spage>195</spage><epage>199</epage><pages>195-199</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The effect of caerulein, a cholecystokinin-like peptide, on the dopamine (DA) system was examined in rat brain. Caerulein, when tested in vitro, had no significant influence on either D-1 or D-2 DA receptors. A single injection of caerulein (400 μg/kg, i.p.) reduced both homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in the striatum. No significant change in DA metabolites was found in the other 7 areas (polar and medial fields of prefrontal cortex, anterior cingulate cortex, nucleus accumbens, tuberculum olfactorium, septum and amygdala). After repeated injections of caerulein (200 μg/kg, i.p., daily for 5 days), the decreases in striatal HVA and DOPAC had disappeared, while the amount of HVA had increased in the nucleus accumbens. These results suggest that peripherally administered caerulein modulates the nigrostriatal and mesolimbic DA neuron systems in the different modes of action.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>6518389</pmid><doi>10.1016/0006-8993(84)90643-7</doi><tpages>5</tpages></addata></record> |
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| subjects | 3,4-dihydroxyphenylacetic acid 3,4-Dihydroxyphenylacetic Acid - analysis [ 3H]spiperone binding Animals Biological and medical sciences Brain - metabolism caerulein Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebral Cortex - analysis Ceruletide - pharmacology Corpus Striatum - analysis Dopamine - metabolism dopamine neuron dopamine-sensitive adenylate cyclase Fundamental and applied biological sciences. Psychology homovanillic acid Homovanillic Acid - analysis Limbic System - analysis Male Mesencephalon - analysis nucleus accumbens Rats Rats, Inbred Strains striatum Substantia Nigra - analysis Vertebrates: nervous system and sense organs |
| title | Effect of systemically administered caerulein on dopamine metabolism in rat brain |
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