15N NMR studies of the binding of C15N- with gold(I) drugs

15N NMR studies of the interaction of 15N cyanide ion with gold(I)-thiomalate (Autm) and gold(I)-thioglucose (Autg) have been carried out at pH* 7.40. The chemical shifts of the two 15N ions containing species Au(C15N)2- and RS-Au-C15N- (where RS- = tm- or tg-) were identified at 265.94 and 260.30 p...

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Veröffentlicht in:	Journal of inorganic biochemistry 1993-06, Vol.50 (4), p.299-304
Hauptverfasser:	ISAB, A. A, GHAZI, I. H, WAZEER, M. I. M, PERZANOWSKI, H. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aurothioglucose Biological and medical sciences Carbon Radioisotopes Cyanides General pharmacology Gold Sodium Thiomalate Magnetic Resonance Spectroscopy - methods Medical sciences Nitrogen Isotopes Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships
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Zusammenfassung:	15N NMR studies of the interaction of 15N cyanide ion with gold(I)-thiomalate (Autm) and gold(I)-thioglucose (Autg) have been carried out at pH* 7.40. The chemical shifts of the two 15N ions containing species Au(C15N)2- and RS-Au-C15N- (where RS- = tm- or tg-) were identified at 265.94 and 260.30 ppm, respectively. From the broadened 15N NMR signals, approximate life times of the RS-Au-CN- species were calculated.
ISSN:	0162-0134 1873-3344
DOI:	10.1016/0162-0134(93)80056-F