Aqueous flow in human eyes is reduced by forskolin, a potent adenylate cyclase activator
Forskolin, which lowers intraocular pressure in rabbits, monkeys, and human subjects, was tested for its effect on the rate of aqueous humor flow and on outflow facility. Topical sodium fluorescein was used to measure the rate of aqueous humor flow in forskolin or placebo treated eyes. Tonography wa...
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| Veröffentlicht in: | Experimental eye research 1984-12, Vol.39 (6), p.745-749 |
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| container_title | Experimental eye research |
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| creator | Burstein, Neal L. Sears, Marvin L. Mead, Alden |
| description | Forskolin, which lowers intraocular pressure in rabbits, monkeys, and human subjects, was tested for its effect on the rate of aqueous humor flow and on outflow facility. Topical sodium fluorescein was used to measure the rate of aqueous humor flow in forskolin or placebo treated eyes. Tonography was used to determine outflow facility before forskolin administration and at 3 hr after administration of the drug.
In eight human subjects who showed reduction of intraocular pressure in response to a single drop of forskolin, flow was reduced by an average of 34%, compared to the contralateral eye during the same period of time. No significant change in outflow facility occurred. The action of forskolin in reducing intraocular pressure was the direct result of a reduction in net aqueous flow. |
| doi_str_mv | 10.1016/0014-4835(84)90073-3 |
| format | Article |
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In eight human subjects who showed reduction of intraocular pressure in response to a single drop of forskolin, flow was reduced by an average of 34%, compared to the contralateral eye during the same period of time. No significant change in outflow facility occurred. The action of forskolin in reducing intraocular pressure was the direct result of a reduction in net aqueous flow.</description><identifier>ISSN: 0014-4835</identifier><identifier>EISSN: 1096-0007</identifier><identifier>DOI: 10.1016/0014-4835(84)90073-3</identifier><identifier>PMID: 6542866</identifier><identifier>CODEN: EXERA6</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>adenylate cyclase ; Adenylyl Cyclases - metabolism ; Adult ; Aged ; aqueous flow ; Aqueous Humor - drug effects ; Aqueous Humor - physiology ; Biological and medical sciences ; cAMP ; Colforsin ; Diterpenes - pharmacology ; Enzyme Activation ; Eye and associated structures. Visual pathways and centers. Vision ; facility ; Female ; forskolin ; Fundamental and applied biological sciences. Psychology ; Humans ; intraocular pressure ; Intraocular Pressure - drug effects ; Male ; Middle Aged ; Vertebrates: nervous system and sense organs</subject><ispartof>Experimental eye research, 1984-12, Vol.39 (6), p.745-749</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-cf460b58540f7b57628a465e61bc8bb59fc8bd6973620ea0d2bde5bd6415c35d3</citedby><cites>FETCH-LOGICAL-c386t-cf460b58540f7b57628a465e61bc8bb59fc8bd6973620ea0d2bde5bd6415c35d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014483584900733$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9121823$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6542866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burstein, Neal L.</creatorcontrib><creatorcontrib>Sears, Marvin L.</creatorcontrib><creatorcontrib>Mead, Alden</creatorcontrib><title>Aqueous flow in human eyes is reduced by forskolin, a potent adenylate cyclase activator</title><title>Experimental eye research</title><addtitle>Exp Eye Res</addtitle><description>Forskolin, which lowers intraocular pressure in rabbits, monkeys, and human subjects, was tested for its effect on the rate of aqueous humor flow and on outflow facility. Topical sodium fluorescein was used to measure the rate of aqueous humor flow in forskolin or placebo treated eyes. Tonography was used to determine outflow facility before forskolin administration and at 3 hr after administration of the drug.
In eight human subjects who showed reduction of intraocular pressure in response to a single drop of forskolin, flow was reduced by an average of 34%, compared to the contralateral eye during the same period of time. No significant change in outflow facility occurred. The action of forskolin in reducing intraocular pressure was the direct result of a reduction in net aqueous flow.</description><subject>adenylate cyclase</subject><subject>Adenylyl Cyclases - metabolism</subject><subject>Adult</subject><subject>Aged</subject><subject>aqueous flow</subject><subject>Aqueous Humor - drug effects</subject><subject>Aqueous Humor - physiology</subject><subject>Biological and medical sciences</subject><subject>cAMP</subject><subject>Colforsin</subject><subject>Diterpenes - pharmacology</subject><subject>Enzyme Activation</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>facility</subject><subject>Female</subject><subject>forskolin</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>intraocular pressure</subject><subject>Intraocular Pressure - drug effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0014-4835</issn><issn>1096-0007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVoSTeb_IMUdAghgTqRrA_Ll0AISVoI9NJAbkKWxlSt19pI9hb_-8pds8eeBs0886J5EDqn5IYSKm8Jobzgiokrxa9rQipWsCO0oqSWBcnPD2h1QD6hk5R-5S7jFT9Gx1LwUkm5Qm_37yOEMeG2C3-w7_HPcWN6DBMk7BOO4EYLDjcTbkNMv0Pn-y_Y4G0YoB-wcdBPnRkA28l2JgE2dvA7M4R4ij62pktwttQ1en16_PHwtXj5_vzt4f6lsEzJobAtl6QRSnDSVo2oZKkMlwIkbaxqGlG3uThZV0yWBAxxZeNA5A6nwjLh2Bpd7nO3MeRT0qA3PlnoOtPPd-lKKF4JLjLI96CNIaUIrd5GvzFx0pToWaiebenZllZc_xOqWV77vOSPzQbcYWkxmOcXy9wka7o2mt76dMBqWlJVzjF3ewyyi52HqJP10Ge3PoIdtAv-___4C1v7kac</recordid><startdate>198412</startdate><enddate>198412</enddate><creator>Burstein, Neal L.</creator><creator>Sears, Marvin L.</creator><creator>Mead, Alden</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198412</creationdate><title>Aqueous flow in human eyes is reduced by forskolin, a potent adenylate cyclase activator</title><author>Burstein, Neal L. ; Sears, Marvin L. ; Mead, Alden</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-cf460b58540f7b57628a465e61bc8bb59fc8bd6973620ea0d2bde5bd6415c35d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>adenylate cyclase</topic><topic>Adenylyl Cyclases - metabolism</topic><topic>Adult</topic><topic>Aged</topic><topic>aqueous flow</topic><topic>Aqueous Humor - drug effects</topic><topic>Aqueous Humor - physiology</topic><topic>Biological and medical sciences</topic><topic>cAMP</topic><topic>Colforsin</topic><topic>Diterpenes - pharmacology</topic><topic>Enzyme Activation</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>facility</topic><topic>Female</topic><topic>forskolin</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>intraocular pressure</topic><topic>Intraocular Pressure - drug effects</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burstein, Neal L.</creatorcontrib><creatorcontrib>Sears, Marvin L.</creatorcontrib><creatorcontrib>Mead, Alden</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental eye research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burstein, Neal L.</au><au>Sears, Marvin L.</au><au>Mead, Alden</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aqueous flow in human eyes is reduced by forskolin, a potent adenylate cyclase activator</atitle><jtitle>Experimental eye research</jtitle><addtitle>Exp Eye Res</addtitle><date>1984-12</date><risdate>1984</risdate><volume>39</volume><issue>6</issue><spage>745</spage><epage>749</epage><pages>745-749</pages><issn>0014-4835</issn><eissn>1096-0007</eissn><coden>EXERA6</coden><abstract>Forskolin, which lowers intraocular pressure in rabbits, monkeys, and human subjects, was tested for its effect on the rate of aqueous humor flow and on outflow facility. Topical sodium fluorescein was used to measure the rate of aqueous humor flow in forskolin or placebo treated eyes. Tonography was used to determine outflow facility before forskolin administration and at 3 hr after administration of the drug.
In eight human subjects who showed reduction of intraocular pressure in response to a single drop of forskolin, flow was reduced by an average of 34%, compared to the contralateral eye during the same period of time. No significant change in outflow facility occurred. The action of forskolin in reducing intraocular pressure was the direct result of a reduction in net aqueous flow.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>6542866</pmid><doi>10.1016/0014-4835(84)90073-3</doi><tpages>5</tpages></addata></record> |
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| ispartof | Experimental eye research, 1984-12, Vol.39 (6), p.745-749 |
| issn | 0014-4835 1096-0007 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | adenylate cyclase Adenylyl Cyclases - metabolism Adult Aged aqueous flow Aqueous Humor - drug effects Aqueous Humor - physiology Biological and medical sciences cAMP Colforsin Diterpenes - pharmacology Enzyme Activation Eye and associated structures. Visual pathways and centers. Vision facility Female forskolin Fundamental and applied biological sciences. Psychology Humans intraocular pressure Intraocular Pressure - drug effects Male Middle Aged Vertebrates: nervous system and sense organs |
| title | Aqueous flow in human eyes is reduced by forskolin, a potent adenylate cyclase activator |
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