Effect of complement (C3) depletion on the generation of memory in rabbits primed with antigens of Trypanosoma evansi
Using the antibody response during secondary exposure of rabbits primed with antigens of Trypanosoma evansi as an indirect measure of immunological memory, it was shown that C3 decomplementaemia resulted in a reduced antibody response, predominated by a reduction in IgM, followed by IgG and then IgA...
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| Veröffentlicht in: | Veterinary parasitology 1993-05, Vol.47 (3), p.205-213 |
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| container_title | Veterinary parasitology |
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| creator | Uche, U.E. Jones, T.W. |
| description | Using the antibody response during secondary exposure of rabbits primed with antigens of
Trypanosoma evansi as an indirect measure of immunological memory, it was shown that C3 decomplementaemia resulted in a reduced antibody response, predominated by a reduction in IgM, followed by IgG and then IgA. While significant differences were observed in the levels of IgG produced by the C3-depleted and C3-intact rabbits no differences were recorded in the levels of IgM and IgA produced by the two groups after C3 decomplementaemia. These results demonstrate that C3 depletion did not abolish memory of the
T. evansi antigen in these rabbits but only modified the magnitude and pattern of their response. The host response to reinfection may be affected by such changes as those observed in this study. |
| doi_str_mv | 10.1016/0304-4017(93)90022-F |
| format | Article |
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Trypanosoma evansi as an indirect measure of immunological memory, it was shown that C3 decomplementaemia resulted in a reduced antibody response, predominated by a reduction in IgM, followed by IgG and then IgA. While significant differences were observed in the levels of IgG produced by the C3-depleted and C3-intact rabbits no differences were recorded in the levels of IgM and IgA produced by the two groups after C3 decomplementaemia. These results demonstrate that C3 depletion did not abolish memory of the
T. evansi antigen in these rabbits but only modified the magnitude and pattern of their response. The host response to reinfection may be affected by such changes as those observed in this study.</description><subject>Animals</subject><subject>antibodies</subject><subject>Antibodies, Protozoan - biosynthesis</subject><subject>anticorps</subject><subject>anticuerpos</subject><subject>Antigen-Antibody Complex - immunology</subject><subject>antigene</subject><subject>antigenos</subject><subject>antigens</subject><subject>Antigens, Protozoan - immunology</subject><subject>Complement C3 - immunology</subject><subject>conejo oryctolagus</subject><subject>Elapid Venoms - immunology</subject><subject>Electrophoresis</subject><subject>Enzyme-Linked Immunosorbent Assay - veterinary</subject><subject>Immunoglobulins - biosynthesis</subject><subject>Immunologic Memory</subject><subject>lapin</subject><subject>Rabbits</subject><subject>Time Factors</subject><subject>Trypanosoma - immunology</subject><subject>trypanosoma evansi</subject><subject>Trypanosomiasis - immunology</subject><subject>Trypanosomiasis - veterinary</subject><issn>0304-4017</issn><issn>1873-2550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVFvFCEQgInR1LP6D9TwZNqHrQPsLstLE3Pp2SYX-1KfCcsOLeYWTtiruX8v6176aEJCYL6ZYT4I-cjgigFrv4KAuqqByQslLhUA59XmFVmxToqKNw28JqsX5C15l_MvAKihlWfkrBNCMC5X5HDjHNqJRkdtHPc7HDFM9GItLumA5Tj5GGhZ0xPSRwyYzHLj6IhjTEfqA02m7_2U6T75EQf6x09P1ITJFz7P5EM67k2IOY6G4rMJ2b8nb5zZZfxw2s_Jz83Nw_q22t5_v1t_21ZWdDBVTCrJnOJSQM-MBIsduK7hlivJTW-ka3veSsShM_0wKCG5EE7VbWss1NyIc_JlqbtP8fcB86RHny3udiZgPGQtm65uVdMWsF5Am2LOCZ2ehzHpqBno2baeVepZpVZC_7OtNyXt06n-oS-jvySd9Jb45yXuTNTmMfmsf2yZUgKgU62a-14vABYLzx6TztZjsDj4VL5FD9H__wV_AfEfl_M</recordid><startdate>19930501</startdate><enddate>19930501</enddate><creator>Uche, U.E.</creator><creator>Jones, T.W.</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930501</creationdate><title>Effect of complement (C3) depletion on the generation of memory in rabbits primed with antigens of Trypanosoma evansi</title><author>Uche, U.E. ; Jones, T.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-17971f92730b1a70ce80f852c2972aba7f6b267eed8abdd937233f9466ac042a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>antibodies</topic><topic>Antibodies, Protozoan - biosynthesis</topic><topic>anticorps</topic><topic>anticuerpos</topic><topic>Antigen-Antibody Complex - immunology</topic><topic>antigene</topic><topic>antigenos</topic><topic>antigens</topic><topic>Antigens, Protozoan - immunology</topic><topic>Complement C3 - immunology</topic><topic>conejo oryctolagus</topic><topic>Elapid Venoms - immunology</topic><topic>Electrophoresis</topic><topic>Enzyme-Linked Immunosorbent Assay - veterinary</topic><topic>Immunoglobulins - biosynthesis</topic><topic>Immunologic Memory</topic><topic>lapin</topic><topic>Rabbits</topic><topic>Time Factors</topic><topic>Trypanosoma - immunology</topic><topic>trypanosoma evansi</topic><topic>Trypanosomiasis - immunology</topic><topic>Trypanosomiasis - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uche, U.E.</creatorcontrib><creatorcontrib>Jones, T.W.</creatorcontrib><creatorcontrib>Royal Veterinary Coll., London (United Kingdom)</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uche, U.E.</au><au>Jones, T.W.</au><aucorp>Royal Veterinary Coll., London (United Kingdom)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of complement (C3) depletion on the generation of memory in rabbits primed with antigens of Trypanosoma evansi</atitle><jtitle>Veterinary parasitology</jtitle><addtitle>Vet Parasitol</addtitle><date>1993-05-01</date><risdate>1993</risdate><volume>47</volume><issue>3</issue><spage>205</spage><epage>213</epage><pages>205-213</pages><issn>0304-4017</issn><eissn>1873-2550</eissn><abstract>Using the antibody response during secondary exposure of rabbits primed with antigens of
Trypanosoma evansi as an indirect measure of immunological memory, it was shown that C3 decomplementaemia resulted in a reduced antibody response, predominated by a reduction in IgM, followed by IgG and then IgA. While significant differences were observed in the levels of IgG produced by the C3-depleted and C3-intact rabbits no differences were recorded in the levels of IgM and IgA produced by the two groups after C3 decomplementaemia. These results demonstrate that C3 depletion did not abolish memory of the
T. evansi antigen in these rabbits but only modified the magnitude and pattern of their response. The host response to reinfection may be affected by such changes as those observed in this study.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>8333127</pmid><doi>10.1016/0304-4017(93)90022-F</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-4017 |
| ispartof | Veterinary parasitology, 1993-05, Vol.47 (3), p.205-213 |
| issn | 0304-4017 1873-2550 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75846956 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals antibodies Antibodies, Protozoan - biosynthesis anticorps anticuerpos Antigen-Antibody Complex - immunology antigene antigenos antigens Antigens, Protozoan - immunology Complement C3 - immunology conejo oryctolagus Elapid Venoms - immunology Electrophoresis Enzyme-Linked Immunosorbent Assay - veterinary Immunoglobulins - biosynthesis Immunologic Memory lapin Rabbits Time Factors Trypanosoma - immunology trypanosoma evansi Trypanosomiasis - immunology Trypanosomiasis - veterinary |
| title | Effect of complement (C3) depletion on the generation of memory in rabbits primed with antigens of Trypanosoma evansi |
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