Autocrine growth mechanism by transforming growth factor (TGF)-beta 1 and TGF-beta 1-receptor regulation by epidermal growth factor in a human endometrial cancer cell line IK-90

Transforming growth factor-beta 1 (TGF-beta 1) enhanced cell proliferation in a concentration-dependent manner in a human endometrial cancer cell line, IK-90. Scatchard analysis of TGF-beta 1 receptor in IK-90 cells, using 125I-TGF-beta 1 as a ligand, revealed the presence of a class of high-affinit...

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Veröffentlicht in:	International journal of cancer 1993-07, Vol.54 (5), p.862-867
Hauptverfasser:	Sakata, M, Kurachi, H, Ikegami, H, Jikihara, H, Morishige, K, Miyake, A, Terakawa, N, Tanizawa, O
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cell Division - drug effects Cell Division - physiology Culture Media, Serum-Free DNA, Neoplasm - drug effects DNA, Neoplasm - metabolism Endometrial Neoplasms - pathology Epidermal Growth Factor - pharmacology Female Humans Receptors, Cell Surface - drug effects Receptors, Cell Surface - metabolism Receptors, Transforming Growth Factor beta Transforming Growth Factor beta - biosynthesis Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - pharmacology Tumor Cells, Cultured
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