Rhabdomyosarcomas in young pigs in a swine breeding farm: a morphologic and immunohistochemical study
Within a 6-month-period, solitary or multiple tumors were observed in 25 young pigs in their first weeks of life in a swine breeding farm. The herd comprised approximately 100 animals, and affected pigs were observed in several litters. The number of affected littermates varied from one to three. Fi...
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| Veröffentlicht in: | Veterinary pathology 1993-05, Vol.30 (3), p.271-279 |
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| creator | Vos, J.H Borst, G.H.A Mulas, J.M. de las Ramaekers, F.C.S Mil, F.N. van Molenbeek, R.F Ivanyi, D Ingh, T.S.G.A.M. van den |
| description | Within a 6-month-period, solitary or multiple tumors were observed in 25 young pigs in their first weeks of life in a swine breeding farm. The herd comprised approximately 100 animals, and affected pigs were observed in several litters. The number of affected littermates varied from one to three. Five animals, all from different litters and with a total of 11 tumors, were studied. Histologically the tumors were classified as undifferentiated sarcomas. Electron microscopic examination of the tumors (n = 3) revealed myogenic differentiation, characterized by the presence of numerous cytoplasmic filaments with longitudinal densities and cytoplasmic dense bodies. Immunohistochemically, all 11 tumors were labeled by vimentin and desmin antibodies. Two tumors from which frozen material was available were additionally labeled by a titin antibody but did not show immunoreactivity with antibodies directed against myosin and α-sarcomeric actin. The tumors were finally diagnosed as undifferentiated rhabdomyosarcomas. The high incidence of these tumors within a short period of time in multiple young animals in different litters indicates a common causative event. The clinical history suggests a genetic cause. |
| doi_str_mv | 10.1177/030098589303000308 |
| format | Article |
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The herd comprised approximately 100 animals, and affected pigs were observed in several litters. The number of affected littermates varied from one to three. Five animals, all from different litters and with a total of 11 tumors, were studied. Histologically the tumors were classified as undifferentiated sarcomas. Electron microscopic examination of the tumors (n = 3) revealed myogenic differentiation, characterized by the presence of numerous cytoplasmic filaments with longitudinal densities and cytoplasmic dense bodies. Immunohistochemically, all 11 tumors were labeled by vimentin and desmin antibodies. Two tumors from which frozen material was available were additionally labeled by a titin antibody but did not show immunoreactivity with antibodies directed against myosin and α-sarcomeric actin. The tumors were finally diagnosed as undifferentiated rhabdomyosarcomas. The high incidence of these tumors within a short period of time in multiple young animals in different litters indicates a common causative event. The clinical history suggests a genetic cause.</description><identifier>ISSN: 0300-9858</identifier><identifier>EISSN: 1544-2217</identifier><identifier>DOI: 10.1177/030098589303000308</identifier><identifier>PMID: 8333108</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Animals ; CERDO ; CHEMISTRY ; CHIMIE ; Cytoskeletal Proteins - analysis ; Disease Outbreaks ; HISTOPATHOLOGIE ; HISTOPATHOLOGY ; HISTOPATOLOGIA ; IMMUNOHISTOCHEMISTRY ; IMMUNOLOGIE ; IMMUNOLOGY ; INMUNOLOGIA ; Microscopy, Electron ; MUSCLE ; MUSCLES ; MUSCULOS ; PORCIN ; QUIMICA ; Rhabdomyosarcoma - chemistry ; Rhabdomyosarcoma - epidemiology ; Rhabdomyosarcoma - pathology ; Rhabdomyosarcoma - veterinary ; SARCOMA ; SARCOME ; Soft Tissue Neoplasms - chemistry ; Soft Tissue Neoplasms - epidemiology ; Soft Tissue Neoplasms - pathology ; Soft Tissue Neoplasms - veterinary ; SWINE ; Swine Diseases - epidemiology ; Swine Diseases - pathology</subject><ispartof>Veterinary pathology, 1993-05, Vol.30 (3), p.271-279</ispartof><rights>1993 American College of Veterinary Pathologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-bdad439edebf2e2ce4df9b81ab85ec366bcde967d0381e41fb7e4debf9acad3e3</citedby><cites>FETCH-LOGICAL-c357t-bdad439edebf2e2ce4df9b81ab85ec366bcde967d0381e41fb7e4debf9acad3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/030098589303000308$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/030098589303000308$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8333108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vos, J.H</creatorcontrib><creatorcontrib>Borst, G.H.A</creatorcontrib><creatorcontrib>Mulas, J.M. de las</creatorcontrib><creatorcontrib>Ramaekers, F.C.S</creatorcontrib><creatorcontrib>Mil, F.N. van</creatorcontrib><creatorcontrib>Molenbeek, R.F</creatorcontrib><creatorcontrib>Ivanyi, D</creatorcontrib><creatorcontrib>Ingh, T.S.G.A.M. van den</creatorcontrib><title>Rhabdomyosarcomas in young pigs in a swine breeding farm: a morphologic and immunohistochemical study</title><title>Veterinary pathology</title><addtitle>Vet Pathol</addtitle><description>Within a 6-month-period, solitary or multiple tumors were observed in 25 young pigs in their first weeks of life in a swine breeding farm. The herd comprised approximately 100 animals, and affected pigs were observed in several litters. The number of affected littermates varied from one to three. Five animals, all from different litters and with a total of 11 tumors, were studied. Histologically the tumors were classified as undifferentiated sarcomas. Electron microscopic examination of the tumors (n = 3) revealed myogenic differentiation, characterized by the presence of numerous cytoplasmic filaments with longitudinal densities and cytoplasmic dense bodies. Immunohistochemically, all 11 tumors were labeled by vimentin and desmin antibodies. Two tumors from which frozen material was available were additionally labeled by a titin antibody but did not show immunoreactivity with antibodies directed against myosin and α-sarcomeric actin. The tumors were finally diagnosed as undifferentiated rhabdomyosarcomas. The high incidence of these tumors within a short period of time in multiple young animals in different litters indicates a common causative event. The clinical history suggests a genetic cause.</description><subject>Animals</subject><subject>CERDO</subject><subject>CHEMISTRY</subject><subject>CHIMIE</subject><subject>Cytoskeletal Proteins - analysis</subject><subject>Disease Outbreaks</subject><subject>HISTOPATHOLOGIE</subject><subject>HISTOPATHOLOGY</subject><subject>HISTOPATOLOGIA</subject><subject>IMMUNOHISTOCHEMISTRY</subject><subject>IMMUNOLOGIE</subject><subject>IMMUNOLOGY</subject><subject>INMUNOLOGIA</subject><subject>Microscopy, Electron</subject><subject>MUSCLE</subject><subject>MUSCLES</subject><subject>MUSCULOS</subject><subject>PORCIN</subject><subject>QUIMICA</subject><subject>Rhabdomyosarcoma - chemistry</subject><subject>Rhabdomyosarcoma - epidemiology</subject><subject>Rhabdomyosarcoma - pathology</subject><subject>Rhabdomyosarcoma - veterinary</subject><subject>SARCOMA</subject><subject>SARCOME</subject><subject>Soft Tissue Neoplasms - chemistry</subject><subject>Soft Tissue Neoplasms - epidemiology</subject><subject>Soft Tissue Neoplasms - pathology</subject><subject>Soft Tissue Neoplasms - veterinary</subject><subject>SWINE</subject><subject>Swine Diseases - epidemiology</subject><subject>Swine Diseases - pathology</subject><issn>0300-9858</issn><issn>1544-2217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFFr2zAUhcVoabNsf6Aw8FPfvEiWbMt7K6HtBoHBuj6LK-naUbGsVIoZ-fdVlrCXwh6EdO_5zgEdQm4Y_cpY264op7STtez48ZWP_EAWrBairCrWXpDFcV0eiWvyMaUXSquqk-0VuZKcc0blguCvLWgb_CEkiCZ4SIWbikOYp6HYueHvBEX64yYsdES0Lgs9RP8tr32Iu20Yw-BMAZMtnPfzFLYu7YPZoncGxiLtZ3v4RC57GBN-Pt9L8vxw_3v9vdz8fPyxvtuUhtftvtQWrOAdWtR9hZVBYftOSwZa1mh402hjsWtaS7lkKFiv24xkuAMDliNfkttT7i6G1xnTXnmXDI4jTBjmpNpaikY2IoPVCTQxpBSxV7voPMSDYlQdu1Xvu82mL-f0WXu0_yznMrO-OukJBlQvYY5T_uz_E29Ojh6CgiG6pJ6fOlHTSgj-Bm0-jSU</recordid><startdate>19930501</startdate><enddate>19930501</enddate><creator>Vos, J.H</creator><creator>Borst, G.H.A</creator><creator>Mulas, J.M. de las</creator><creator>Ramaekers, F.C.S</creator><creator>Mil, F.N. van</creator><creator>Molenbeek, R.F</creator><creator>Ivanyi, D</creator><creator>Ingh, T.S.G.A.M. van den</creator><general>SAGE Publications</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930501</creationdate><title>Rhabdomyosarcomas in young pigs in a swine breeding farm: a morphologic and immunohistochemical study</title><author>Vos, J.H ; Borst, G.H.A ; Mulas, J.M. de las ; Ramaekers, F.C.S ; Mil, F.N. van ; Molenbeek, R.F ; Ivanyi, D ; Ingh, T.S.G.A.M. van den</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-bdad439edebf2e2ce4df9b81ab85ec366bcde967d0381e41fb7e4debf9acad3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>CERDO</topic><topic>CHEMISTRY</topic><topic>CHIMIE</topic><topic>Cytoskeletal Proteins - analysis</topic><topic>Disease Outbreaks</topic><topic>HISTOPATHOLOGIE</topic><topic>HISTOPATHOLOGY</topic><topic>HISTOPATOLOGIA</topic><topic>IMMUNOHISTOCHEMISTRY</topic><topic>IMMUNOLOGIE</topic><topic>IMMUNOLOGY</topic><topic>INMUNOLOGIA</topic><topic>Microscopy, Electron</topic><topic>MUSCLE</topic><topic>MUSCLES</topic><topic>MUSCULOS</topic><topic>PORCIN</topic><topic>QUIMICA</topic><topic>Rhabdomyosarcoma - chemistry</topic><topic>Rhabdomyosarcoma - epidemiology</topic><topic>Rhabdomyosarcoma - pathology</topic><topic>Rhabdomyosarcoma - veterinary</topic><topic>SARCOMA</topic><topic>SARCOME</topic><topic>Soft Tissue Neoplasms - chemistry</topic><topic>Soft Tissue Neoplasms - epidemiology</topic><topic>Soft Tissue Neoplasms - pathology</topic><topic>Soft Tissue Neoplasms - veterinary</topic><topic>SWINE</topic><topic>Swine Diseases - epidemiology</topic><topic>Swine Diseases - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vos, J.H</creatorcontrib><creatorcontrib>Borst, G.H.A</creatorcontrib><creatorcontrib>Mulas, J.M. de las</creatorcontrib><creatorcontrib>Ramaekers, F.C.S</creatorcontrib><creatorcontrib>Mil, F.N. van</creatorcontrib><creatorcontrib>Molenbeek, R.F</creatorcontrib><creatorcontrib>Ivanyi, D</creatorcontrib><creatorcontrib>Ingh, T.S.G.A.M. van den</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vos, J.H</au><au>Borst, G.H.A</au><au>Mulas, J.M. de las</au><au>Ramaekers, F.C.S</au><au>Mil, F.N. van</au><au>Molenbeek, R.F</au><au>Ivanyi, D</au><au>Ingh, T.S.G.A.M. van den</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rhabdomyosarcomas in young pigs in a swine breeding farm: a morphologic and immunohistochemical study</atitle><jtitle>Veterinary pathology</jtitle><addtitle>Vet Pathol</addtitle><date>1993-05-01</date><risdate>1993</risdate><volume>30</volume><issue>3</issue><spage>271</spage><epage>279</epage><pages>271-279</pages><issn>0300-9858</issn><eissn>1544-2217</eissn><abstract>Within a 6-month-period, solitary or multiple tumors were observed in 25 young pigs in their first weeks of life in a swine breeding farm. The herd comprised approximately 100 animals, and affected pigs were observed in several litters. The number of affected littermates varied from one to three. Five animals, all from different litters and with a total of 11 tumors, were studied. Histologically the tumors were classified as undifferentiated sarcomas. Electron microscopic examination of the tumors (n = 3) revealed myogenic differentiation, characterized by the presence of numerous cytoplasmic filaments with longitudinal densities and cytoplasmic dense bodies. Immunohistochemically, all 11 tumors were labeled by vimentin and desmin antibodies. Two tumors from which frozen material was available were additionally labeled by a titin antibody but did not show immunoreactivity with antibodies directed against myosin and α-sarcomeric actin. The tumors were finally diagnosed as undifferentiated rhabdomyosarcomas. The high incidence of these tumors within a short period of time in multiple young animals in different litters indicates a common causative event. The clinical history suggests a genetic cause.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>8333108</pmid><doi>10.1177/030098589303000308</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0300-9858 |
| ispartof | Veterinary pathology, 1993-05, Vol.30 (3), p.271-279 |
| issn | 0300-9858 1544-2217 |
| language | eng |
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| source | MEDLINE; SAGE Complete |
| subjects | Animals CERDO CHEMISTRY CHIMIE Cytoskeletal Proteins - analysis Disease Outbreaks HISTOPATHOLOGIE HISTOPATHOLOGY HISTOPATOLOGIA IMMUNOHISTOCHEMISTRY IMMUNOLOGIE IMMUNOLOGY INMUNOLOGIA Microscopy, Electron MUSCLE MUSCLES MUSCULOS PORCIN QUIMICA Rhabdomyosarcoma - chemistry Rhabdomyosarcoma - epidemiology Rhabdomyosarcoma - pathology Rhabdomyosarcoma - veterinary SARCOMA SARCOME Soft Tissue Neoplasms - chemistry Soft Tissue Neoplasms - epidemiology Soft Tissue Neoplasms - pathology Soft Tissue Neoplasms - veterinary SWINE Swine Diseases - epidemiology Swine Diseases - pathology |
| title | Rhabdomyosarcomas in young pigs in a swine breeding farm: a morphologic and immunohistochemical study |
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