Mutation of the Tumor Suppressor Gene TP53 Is Not Detected in Psoriatic Skin
We investigated the tumor-suppressor gene, TP53, in psoriatic skin at gene (GPS3) and protein (p53) levels. No mutation was detected in the seven exons analyzed using a combination of polymerase chain reaction and single-strand conformation polymorphism techniques. In addition, by immunohistochemist...
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| Veröffentlicht in: | Journal of investigative dermatology 1993-07, Vol.101 (1), p.100-102 |
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| creator | Molès, Jean-Pierre Theillet, Charles Basset-Sèguin, Nicole Guilhou, Jean-Jacques |
| description | We investigated the tumor-suppressor gene, TP53, in psoriatic skin at gene (GPS3) and protein (p53) levels. No mutation was detected in the seven exons analyzed using a combination of polymerase chain reaction and single-strand conformation polymorphism techniques. In addition, by immunohistochemistry using three different anti-p53 antibodies, no positive staining, reported to be associated with mutations and/or abnormal expression of the TP53 gene, was observed in psoriatic skin biopsies, in contrast to recent reports. These results suggest that the proliferative status of psoriatic keratinocytes does not implicate the TP53 gene. |
| doi_str_mv | 10.1111/1523-1747.ep12360920 |
| format | Article |
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No mutation was detected in the seven exons analyzed using a combination of polymerase chain reaction and single-strand conformation polymorphism techniques. In addition, by immunohistochemistry using three different anti-p53 antibodies, no positive staining, reported to be associated with mutations and/or abnormal expression of the TP53 gene, was observed in psoriatic skin biopsies, in contrast to recent reports. These results suggest that the proliferative status of psoriatic keratinocytes does not implicate the TP53 gene.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1111/1523-1747.ep12360920</identifier><identifier>PMID: 8331291</identifier><identifier>CODEN: JIDEAE</identifier><language>eng</language><publisher>Danvers, MA: Elsevier Inc</publisher><subject>Base Sequence ; Biological and medical sciences ; Dermatology ; DNA, Single-Stranded ; Genes, Tumor Suppressor ; Humans ; Immunohistochemistry ; Medical sciences ; Molecular Conformation ; Molecular Probes - genetics ; Molecular Sequence Data ; Mutation ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Psoriasis - genetics ; Psoriasis. Parapsoriasis. 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No mutation was detected in the seven exons analyzed using a combination of polymerase chain reaction and single-strand conformation polymorphism techniques. In addition, by immunohistochemistry using three different anti-p53 antibodies, no positive staining, reported to be associated with mutations and/or abnormal expression of the TP53 gene, was observed in psoriatic skin biopsies, in contrast to recent reports. These results suggest that the proliferative status of psoriatic keratinocytes does not implicate the TP53 gene.</description><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>DNA, Single-Stranded</subject><subject>Genes, Tumor Suppressor</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Medical sciences</subject><subject>Molecular Conformation</subject><subject>Molecular Probes - genetics</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Psoriasis - genetics</subject><subject>Psoriasis. Parapsoriasis. Lichen</subject><subject>Skin - metabolism</subject><subject>Skin - physiopathology</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1rFDEUhoModVv9Bwq5EO-mnnzP3AhSbS2sWmgF70KanGB0d2aaZAT_vVl22d55bnI47wfhIeQVg3PW5h1TXHTMSHOOM-NCw8DhCVkdz0_JCoDzjgP_8ZyclvILgGmp-hNy0gvB-MBWZP1lqa6maaRTpPUn0rtlO2V6u8xzxlLaeoVju94oQa8L_TpV-hEr-oqBppHeNEdqeU9vf6fxBXkW3abgy8N7Rr5ffrq7-Nytv11dX3xYd15CXzsjAggUmkcXwChjdFBCBoEuyhgB9D1nTjljYnSDxEFDz4IJAaJCjSDEGXm7753z9LBgqXabisfNxo04LcUa1UttBDSj3Bt9nkrJGO2c09blv5aB3UG0O1p2R8s-Qmyx14f-5X6L4Rg6UGv6m4PuinebmN3oUznaZK-BQf9YM7q6ZDzqSjOmhp3-fq9jY_UnYbbFJxw9hpQbYRum9P9__gOO5JYI</recordid><startdate>19930701</startdate><enddate>19930701</enddate><creator>Molès, Jean-Pierre</creator><creator>Theillet, Charles</creator><creator>Basset-Sèguin, Nicole</creator><creator>Guilhou, Jean-Jacques</creator><general>Elsevier Inc</general><general>Nature Publishing</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930701</creationdate><title>Mutation of the Tumor Suppressor Gene TP53 Is Not Detected in Psoriatic Skin</title><author>Molès, Jean-Pierre ; Theillet, Charles ; Basset-Sèguin, Nicole ; Guilhou, Jean-Jacques</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-73d03e362fad075776d534d3eaf4ff006b21a5a77ffa94e96081d7dd0f5e6e033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>DNA, Single-Stranded</topic><topic>Genes, Tumor Suppressor</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Medical sciences</topic><topic>Molecular Conformation</topic><topic>Molecular Probes - genetics</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Psoriasis - genetics</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><topic>Skin - metabolism</topic><topic>Skin - physiopathology</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Molès, Jean-Pierre</creatorcontrib><creatorcontrib>Theillet, Charles</creatorcontrib><creatorcontrib>Basset-Sèguin, Nicole</creatorcontrib><creatorcontrib>Guilhou, Jean-Jacques</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Molès, Jean-Pierre</au><au>Theillet, Charles</au><au>Basset-Sèguin, Nicole</au><au>Guilhou, Jean-Jacques</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mutation of the Tumor Suppressor Gene TP53 Is Not Detected in Psoriatic Skin</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>1993-07-01</date><risdate>1993</risdate><volume>101</volume><issue>1</issue><spage>100</spage><epage>102</epage><pages>100-102</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><coden>JIDEAE</coden><abstract>We investigated the tumor-suppressor gene, TP53, in psoriatic skin at gene (GPS3) and protein (p53) levels. No mutation was detected in the seven exons analyzed using a combination of polymerase chain reaction and single-strand conformation polymorphism techniques. In addition, by immunohistochemistry using three different anti-p53 antibodies, no positive staining, reported to be associated with mutations and/or abnormal expression of the TP53 gene, was observed in psoriatic skin biopsies, in contrast to recent reports. These results suggest that the proliferative status of psoriatic keratinocytes does not implicate the TP53 gene.</abstract><cop>Danvers, MA</cop><pub>Elsevier Inc</pub><pmid>8331291</pmid><doi>10.1111/1523-1747.ep12360920</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of investigative dermatology, 1993-07, Vol.101 (1), p.100-102 |
| issn | 0022-202X 1523-1747 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Base Sequence Biological and medical sciences Dermatology DNA, Single-Stranded Genes, Tumor Suppressor Humans Immunohistochemistry Medical sciences Molecular Conformation Molecular Probes - genetics Molecular Sequence Data Mutation Polymerase Chain Reaction Polymorphism, Genetic Psoriasis - genetics Psoriasis. Parapsoriasis. Lichen Skin - metabolism Skin - physiopathology Tumor Suppressor Protein p53 - metabolism |
| title | Mutation of the Tumor Suppressor Gene TP53 Is Not Detected in Psoriatic Skin |
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