Photosensitized irreversible binding of estrone to protein via a hydroperoxide intermediate: An explanation of (photo-)allergic side-effects of estrogens

After irradiation (γ>425 nm) for 15 min of a solution of [4- 14C]-estrone, albumin and the photosensitizer hematoporphyrin in phosphate buffer, more than 30% of the radioactivity could not be extracted. When the protein was added after irradiation, irreversible binding also occurred. Sephadex gel...

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Veröffentlicht in:	Biochemical and biophysical research communications 1984-12, Vol.125 (2), p.675-681
Hauptverfasser:	Sedee, A.G.J., Beijersbergen van Henegouwen, G.M.J., Lusthof, K.J., Lodder, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Hypersensitivity Estrogens - adverse effects Estrone - metabolism Estrone - radiation effects Hematoporphyrins Humans Peroxides Photochemistry Protein Binding Protein Denaturation Serum Albumin - metabolism Serum Albumin - radiation effects
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