Excimer laser sclerostomy: The in vitro development of a modified open mask delivery system
The argon fluoride (ArF) excimer laser at 193 nm ablates the ocular tissues with a new order of precision and virtually no adjacent damage. A glaucoma filtration operation has been designed in which small-bore sclerostomies are created using the ArF excimer laser delivered through an open mask. The...
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| Veröffentlicht in: | Eye (London) 1993-01, Vol.7 (1), p.47-52 |
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| creator | Allan, B D S Van Saarloos, P P Russo, A V Cooper, R L Constable, I J |
| description | The argon fluoride (ArF) excimer laser at 193 nm ablates the ocular tissues with a new order of precision and virtually no adjacent damage. A glaucoma filtration operation has been designed in which small-bore sclerostomies are created using the ArF excimer laser delivered through an open mask. The mask plicates the conjunctiva at the limbus prior to ablation. Removing the mask at the end of the procedure allows the conjunctiva to relax back to its original position, separating the conjunctival and scleral wounds. Formal conjunctival dissection is thus avoided. Feasibility studies in cadaver pig eyes, using a fluence per pulse of 400 mJ/cm2 and a pulse repetition rate of 20 Hz, indicate that sclerostomies of 300 µm diameter can be reliably formed if an en-face air jet is built into the mask to raise the pressure in the target area, preventing aqueous flooding. |
| doi_str_mv | 10.1038/eye.1993.11 |
| format | Article |
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A glaucoma filtration operation has been designed in which small-bore sclerostomies are created using the ArF excimer laser delivered through an open mask. The mask plicates the conjunctiva at the limbus prior to ablation. Removing the mask at the end of the procedure allows the conjunctiva to relax back to its original position, separating the conjunctival and scleral wounds. Formal conjunctival dissection is thus avoided. Feasibility studies in cadaver pig eyes, using a fluence per pulse of 400 mJ/cm2 and a pulse repetition rate of 20 Hz, indicate that sclerostomies of 300 µm diameter can be reliably formed if an en-face air jet is built into the mask to raise the pressure in the target area, preventing aqueous flooding.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/eye.1993.11</identifier><identifier>PMID: 8325423</identifier><identifier>CODEN: EYEEEC</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Biological and medical sciences ; Conjunctiva - surgery ; Glaucoma - surgery ; In Vitro Techniques ; Laboratory Medicine ; Laser Therapy ; Masks ; Medical sciences ; Medicine ; Medicine & Public Health ; Microscopy, Electron, Scanning ; Ophthalmology ; Pharmaceutical Sciences/Technology ; Pressure ; Sclera - ultrastructure ; Sclerostomy - methods ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. 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A glaucoma filtration operation has been designed in which small-bore sclerostomies are created using the ArF excimer laser delivered through an open mask. The mask plicates the conjunctiva at the limbus prior to ablation. Removing the mask at the end of the procedure allows the conjunctiva to relax back to its original position, separating the conjunctival and scleral wounds. Formal conjunctival dissection is thus avoided. Feasibility studies in cadaver pig eyes, using a fluence per pulse of 400 mJ/cm2 and a pulse repetition rate of 20 Hz, indicate that sclerostomies of 300 µm diameter can be reliably formed if an en-face air jet is built into the mask to raise the pressure in the target area, preventing aqueous flooding.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Conjunctiva - surgery</subject><subject>Glaucoma - surgery</subject><subject>In Vitro Techniques</subject><subject>Laboratory Medicine</subject><subject>Laser Therapy</subject><subject>Masks</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microscopy, Electron, Scanning</subject><subject>Ophthalmology</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Pressure</subject><subject>Sclera - ultrastructure</subject><subject>Sclerostomy - methods</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the eye and orbit</subject><subject>Surgical Oncology</subject><subject>Swine</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkLtLBDEQh4Moej4qayGF2Oieee0jdiLnAwSbEwSLkM3OanSzOZO9w_3vjdxhJQwzxe9jhvkQOqZkSgmvLmGEKZWSTyndQhMqyiLLRS620YTInGSMsZc9tB_jByEpLMku2q04ywXjE_Q6-zbWQcCdjqlH00HwcfBuvMLzd8C2xys7BI8bWEHnFw76AfsWa-x8Y1sLDfYL6LHT8TMxnV1BGHEc4wDuEO20uotwtJkH6Pl2Nr-5zx6f7h5urh8zwwmjWU2YoXVLCimhAspMXZuG1bygoFNxwZu61LnMCygq0mjNSkGZLlsgsoam4gfobL13EfzXEuKgnI0Guk734JdRlXklmMhlAs_XoEk_xgCtWgTrdBgVJepXpUoq1a9KRWmiTzZrl7WD5o_duEv56SbX0eiuDbo3Nv5homSMSpGwizUWU9K_QVAffhn6JOTfqz-ymova</recordid><startdate>19930101</startdate><enddate>19930101</enddate><creator>Allan, B D S</creator><creator>Van Saarloos, P P</creator><creator>Russo, A V</creator><creator>Cooper, R L</creator><creator>Constable, I J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930101</creationdate><title>Excimer laser sclerostomy: The in vitro development of a modified open mask delivery system</title><author>Allan, B D S ; Van Saarloos, P P ; Russo, A V ; Cooper, R L ; Constable, I J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3021-b02c1bf0699e8e12cbbcd2b361ea1ea343db7a5956e680daa27412a7fe09bed83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Conjunctiva - surgery</topic><topic>Glaucoma - surgery</topic><topic>In Vitro Techniques</topic><topic>Laboratory Medicine</topic><topic>Laser Therapy</topic><topic>Masks</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microscopy, Electron, Scanning</topic><topic>Ophthalmology</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Pressure</topic><topic>Sclera - ultrastructure</topic><topic>Sclerostomy - methods</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the eye and orbit</topic><topic>Surgical Oncology</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Allan, B D S</creatorcontrib><creatorcontrib>Van Saarloos, P P</creatorcontrib><creatorcontrib>Russo, A V</creatorcontrib><creatorcontrib>Cooper, R L</creatorcontrib><creatorcontrib>Constable, I J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allan, B D S</au><au>Van Saarloos, P P</au><au>Russo, A V</au><au>Cooper, R L</au><au>Constable, I J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Excimer laser sclerostomy: The in vitro development of a modified open mask delivery system</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>1993-01-01</date><risdate>1993</risdate><volume>7</volume><issue>1</issue><spage>47</spage><epage>52</epage><pages>47-52</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><coden>EYEEEC</coden><abstract>The argon fluoride (ArF) excimer laser at 193 nm ablates the ocular tissues with a new order of precision and virtually no adjacent damage. A glaucoma filtration operation has been designed in which small-bore sclerostomies are created using the ArF excimer laser delivered through an open mask. The mask plicates the conjunctiva at the limbus prior to ablation. Removing the mask at the end of the procedure allows the conjunctiva to relax back to its original position, separating the conjunctival and scleral wounds. Formal conjunctival dissection is thus avoided. Feasibility studies in cadaver pig eyes, using a fluence per pulse of 400 mJ/cm2 and a pulse repetition rate of 20 Hz, indicate that sclerostomies of 300 µm diameter can be reliably formed if an en-face air jet is built into the mask to raise the pressure in the target area, preventing aqueous flooding.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>8325423</pmid><doi>10.1038/eye.1993.11</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Eye (London), 1993-01, Vol.7 (1), p.47-52 |
| issn | 0950-222X 1476-5454 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Biological and medical sciences Conjunctiva - surgery Glaucoma - surgery In Vitro Techniques Laboratory Medicine Laser Therapy Masks Medical sciences Medicine Medicine & Public Health Microscopy, Electron, Scanning Ophthalmology Pharmaceutical Sciences/Technology Pressure Sclera - ultrastructure Sclerostomy - methods Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the eye and orbit Surgical Oncology Swine |
| title | Excimer laser sclerostomy: The in vitro development of a modified open mask delivery system |
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