A serum protein affecting the regulation of the immune system
A thermostable alpha 2 globulin inhibiting the immunoglobulin/anti-immunoglobulin reaction was demonstrated working with subacute sclerosing panencephalitis (SSPE) and control serum IgG. This protein was isolated from SSPE and normal human blood, it inhibits the immunoglobulin/anti-immunoglobulin re...
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| Veröffentlicht in: | Neurochemical research 1984-10, Vol.9 (10), p.1423-1430 |
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| container_title | Neurochemical research |
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| creator | KARCHER, D LOWENTHAL, A STOPPIE, P NOPPE, M |
| description | A thermostable alpha 2 globulin inhibiting the immunoglobulin/anti-immunoglobulin reaction was demonstrated working with subacute sclerosing panencephalitis (SSPE) and control serum IgG. This protein was isolated from SSPE and normal human blood, it inhibits the immunoglobulin/anti-immunoglobulin reaction but no other antigen/antibody reactions when applying different immunochemical methods such as nitrocellulose immunofixation, 2 site immunoradiometric assay, solid phase radioimmunoassay in coated cups. This was demonstrated, working on the one hand with measles virus strain Edmonston or SSPE virus strain D.R. and SSPE serum and on the other hand with IgG from SSPE and control serum. This alpha 2 globulin, an inhibiting protein, appears to be related to "normal immunosuppressive protein". |
| doi_str_mv | 10.1007/BF00964669 |
| format | Article |
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This protein was isolated from SSPE and normal human blood, it inhibits the immunoglobulin/anti-immunoglobulin reaction but no other antigen/antibody reactions when applying different immunochemical methods such as nitrocellulose immunofixation, 2 site immunoradiometric assay, solid phase radioimmunoassay in coated cups. This was demonstrated, working on the one hand with measles virus strain Edmonston or SSPE virus strain D.R. and SSPE serum and on the other hand with IgG from SSPE and control serum. This alpha 2 globulin, an inhibiting protein, appears to be related to "normal immunosuppressive protein".</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/BF00964669</identifier><identifier>PMID: 6083468</identifier><identifier>CODEN: NEREDZ</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Alpha-Globulins - immunology ; Antibodies, Viral - immunology ; Antigen-Antibody Reactions ; Antigens, Viral - immunology ; Biological and medical sciences ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Immunoglobulins - immunology ; Immunosuppression ; Immunosuppressive Agents - blood ; Measles virus - immunology ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Subacute Sclerosing Panencephalitis - blood ; Subacute Sclerosing Panencephalitis - immunology</subject><ispartof>Neurochemical research, 1984-10, Vol.9 (10), p.1423-1430</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-ef9929cf8b5538b3fbe8ac383c18801ba059c7c12c855e1012308cc0d5deacc53</citedby><cites>FETCH-LOGICAL-c342t-ef9929cf8b5538b3fbe8ac383c18801ba059c7c12c855e1012308cc0d5deacc53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9076907$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6083468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KARCHER, D</creatorcontrib><creatorcontrib>LOWENTHAL, A</creatorcontrib><creatorcontrib>STOPPIE, P</creatorcontrib><creatorcontrib>NOPPE, M</creatorcontrib><title>A serum protein affecting the regulation of the immune system</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><description>A thermostable alpha 2 globulin inhibiting the immunoglobulin/anti-immunoglobulin reaction was demonstrated working with subacute sclerosing panencephalitis (SSPE) and control serum IgG. This protein was isolated from SSPE and normal human blood, it inhibits the immunoglobulin/anti-immunoglobulin reaction but no other antigen/antibody reactions when applying different immunochemical methods such as nitrocellulose immunofixation, 2 site immunoradiometric assay, solid phase radioimmunoassay in coated cups. This was demonstrated, working on the one hand with measles virus strain Edmonston or SSPE virus strain D.R. and SSPE serum and on the other hand with IgG from SSPE and control serum. This alpha 2 globulin, an inhibiting protein, appears to be related to "normal immunosuppressive protein".</description><subject>Alpha-Globulins - immunology</subject><subject>Antibodies, Viral - immunology</subject><subject>Antigen-Antibody Reactions</subject><subject>Antigens, Viral - immunology</subject><subject>Biological and medical sciences</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Immunoglobulins - immunology</subject><subject>Immunosuppression</subject><subject>Immunosuppressive Agents - blood</subject><subject>Measles virus - immunology</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Subacute Sclerosing Panencephalitis - blood</subject><subject>Subacute Sclerosing Panencephalitis - immunology</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb1PwzAQxS0EKqWwsCNlQAxIgXMcO_bAUCoKSJVYYI6c67kE5aPYydD_npRWZWQ66d5PT3fvMXbJ4Y4DZPePcwCjUqXMERtzmYlYGRDHbAxCpbHgBk7ZWQhfAAOe8BEbKdAiVXrMHqZRIN_X0dq3HZVNZJ0j7MpmFXWfFHla9ZXtyraJWve7Keu6bygKm9BRfc5OnK0CXeznhH3Mn95nL_Hi7fl1Nl3EKNKki8kZkxh0upBS6EK4grRFoQVyrYEXFqTBDHmCWkriwBMBGhGWckkWUYoJu9n5Dld-9xS6vC4DUlXZhto-5JnU6fDl_yBPQabKbMHbHYi-DcGTy9e-rK3f5Bzybaj5X6gDfLV37Yualgd0n-KgX-91G9BWztsGy3DADGRDH5n4ARfofQg</recordid><startdate>198410</startdate><enddate>198410</enddate><creator>KARCHER, D</creator><creator>LOWENTHAL, A</creator><creator>STOPPIE, P</creator><creator>NOPPE, M</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198410</creationdate><title>A serum protein affecting the regulation of the immune system</title><author>KARCHER, D ; LOWENTHAL, A ; STOPPIE, P ; NOPPE, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-ef9929cf8b5538b3fbe8ac383c18801ba059c7c12c855e1012308cc0d5deacc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Alpha-Globulins - immunology</topic><topic>Antibodies, Viral - immunology</topic><topic>Antigen-Antibody Reactions</topic><topic>Antigens, Viral - immunology</topic><topic>Biological and medical sciences</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Immunoglobulins - immunology</topic><topic>Immunosuppression</topic><topic>Immunosuppressive Agents - blood</topic><topic>Measles virus - immunology</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Subacute Sclerosing Panencephalitis - blood</topic><topic>Subacute Sclerosing Panencephalitis - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KARCHER, D</creatorcontrib><creatorcontrib>LOWENTHAL, A</creatorcontrib><creatorcontrib>STOPPIE, P</creatorcontrib><creatorcontrib>NOPPE, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurochemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KARCHER, D</au><au>LOWENTHAL, A</au><au>STOPPIE, P</au><au>NOPPE, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A serum protein affecting the regulation of the immune system</atitle><jtitle>Neurochemical research</jtitle><addtitle>Neurochem Res</addtitle><date>1984-10</date><risdate>1984</risdate><volume>9</volume><issue>10</issue><spage>1423</spage><epage>1430</epage><pages>1423-1430</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><coden>NEREDZ</coden><abstract>A thermostable alpha 2 globulin inhibiting the immunoglobulin/anti-immunoglobulin reaction was demonstrated working with subacute sclerosing panencephalitis (SSPE) and control serum IgG. This protein was isolated from SSPE and normal human blood, it inhibits the immunoglobulin/anti-immunoglobulin reaction but no other antigen/antibody reactions when applying different immunochemical methods such as nitrocellulose immunofixation, 2 site immunoradiometric assay, solid phase radioimmunoassay in coated cups. This was demonstrated, working on the one hand with measles virus strain Edmonston or SSPE virus strain D.R. and SSPE serum and on the other hand with IgG from SSPE and control serum. This alpha 2 globulin, an inhibiting protein, appears to be related to "normal immunosuppressive protein".</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>6083468</pmid><doi>10.1007/BF00964669</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-3190 |
| ispartof | Neurochemical research, 1984-10, Vol.9 (10), p.1423-1430 |
| issn | 0364-3190 1573-6903 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75841905 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Alpha-Globulins - immunology Antibodies, Viral - immunology Antigen-Antibody Reactions Antigens, Viral - immunology Biological and medical sciences Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Immunoglobulins - immunology Immunosuppression Immunosuppressive Agents - blood Measles virus - immunology Medical sciences Nervous system (semeiology, syndromes) Neurology Subacute Sclerosing Panencephalitis - blood Subacute Sclerosing Panencephalitis - immunology |
| title | A serum protein affecting the regulation of the immune system |
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