Dose requirements of ICI 35,868 (Propofol, ‘Diprivan’) in a new formulation for induction of anaesthesia
Summary In order to avoid Cremophor‐related reactions and reduce the incidence of pain on injection, di‐isopropylphenol (ICI 35,868; propofol) has been reformulated as an emulsion. One hundred and fifteen patients received an induction dose of propofol in the new formulation. The dose required to in...
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| Veröffentlicht in: | Anaesthesia 1984-12, Vol.39 (12), p.1168-1171 |
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| container_title | Anaesthesia |
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| creator | CUMMINGS, G. C. DIXON, J. KAY, N. H. WINDSOR, J. P. W. MAJOR, E. MORGAN, M. SEAR, J. W. SPENCE, A. A. STEPHENSON, D. K. |
| description | Summary
In order to avoid Cremophor‐related reactions and reduce the incidence of pain on injection, di‐isopropylphenol (ICI 35,868; propofol) has been reformulated as an emulsion. One hundred and fifteen patients received an induction dose of propofol in the new formulation. The dose required to induce anaesthesia in 95% of healthy, unpremedicated patients was 2.5 mg/kg. Induction was associated with a degree of cardiovascular and respiratory depression. There were no adverse reactions although there were a number of minor side‐effects. The incidence of pain on injection was low (3%) and the overall quality of induction was assessed as good or adequate in 92% of patients. |
| doi_str_mv | 10.1111/j.1365-2044.1984.tb06425.x |
| format | Article |
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In order to avoid Cremophor‐related reactions and reduce the incidence of pain on injection, di‐isopropylphenol (ICI 35,868; propofol) has been reformulated as an emulsion. One hundred and fifteen patients received an induction dose of propofol in the new formulation. The dose required to induce anaesthesia in 95% of healthy, unpremedicated patients was 2.5 mg/kg. Induction was associated with a degree of cardiovascular and respiratory depression. There were no adverse reactions although there were a number of minor side‐effects. The incidence of pain on injection was low (3%) and the overall quality of induction was assessed as good or adequate in 92% of patients.</description><identifier>ISSN: 0003-2409</identifier><identifier>EISSN: 1365-2044</identifier><identifier>DOI: 10.1111/j.1365-2044.1984.tb06425.x</identifier><identifier>PMID: 6335003</identifier><identifier>CODEN: ANASAB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Anaesthetics, intravenous ; Anesthesia ; Anesthesia, Intravenous ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anesthetics - administration & dosage ; Biological and medical sciences ; Blood Pressure - drug effects ; Depression, Chemical ; Fat Emulsions, Intravenous ; Female ; General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation ; Heart Rate - drug effects ; Humans ; Male ; Medical sciences ; Middle Aged ; Phenols - administration & dosage ; Phenols - pharmacology ; Propofol ; Respiration - drug effects</subject><ispartof>Anaesthesia, 1984-12, Vol.39 (12), p.1168-1171</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4728-9c16961c1837c11193c57a6a226c212f6229b985e7f7df7f7654d2379b4e57a83</citedby><cites>FETCH-LOGICAL-c4728-9c16961c1837c11193c57a6a226c212f6229b985e7f7df7f7654d2379b4e57a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2044.1984.tb06425.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2044.1984.tb06425.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8957677$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6335003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CUMMINGS, G. C.</creatorcontrib><creatorcontrib>DIXON, J.</creatorcontrib><creatorcontrib>KAY, N. H.</creatorcontrib><creatorcontrib>WINDSOR, J. P. W.</creatorcontrib><creatorcontrib>MAJOR, E.</creatorcontrib><creatorcontrib>MORGAN, M.</creatorcontrib><creatorcontrib>SEAR, J. W.</creatorcontrib><creatorcontrib>SPENCE, A. A.</creatorcontrib><creatorcontrib>STEPHENSON, D. K.</creatorcontrib><title>Dose requirements of ICI 35,868 (Propofol, ‘Diprivan’) in a new formulation for induction of anaesthesia</title><title>Anaesthesia</title><addtitle>Anaesthesia</addtitle><description>Summary
In order to avoid Cremophor‐related reactions and reduce the incidence of pain on injection, di‐isopropylphenol (ICI 35,868; propofol) has been reformulated as an emulsion. One hundred and fifteen patients received an induction dose of propofol in the new formulation. The dose required to induce anaesthesia in 95% of healthy, unpremedicated patients was 2.5 mg/kg. Induction was associated with a degree of cardiovascular and respiratory depression. There were no adverse reactions although there were a number of minor side‐effects. The incidence of pain on injection was low (3%) and the overall quality of induction was assessed as good or adequate in 92% of patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anaesthetics, intravenous</subject><subject>Anesthesia</subject><subject>Anesthesia, Intravenous</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anesthetics - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Depression, Chemical</subject><subject>Fat Emulsions, Intravenous</subject><subject>Female</subject><subject>General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Phenols - administration & dosage</subject><subject>Phenols - pharmacology</subject><subject>Propofol</subject><subject>Respiration - drug effects</subject><issn>0003-2409</issn><issn>1365-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkM1uEzEQxy0EKqHwCEgWQqhI3cXfHz01SguNVAEHOFuOY4uNdtepnaXtrY8Br9cnwUtWudeHsUf__8x4fgC8w6jG5Xza1JgKXhHEWI21YvVuhQQjvL57BmYH6TmYIYRoRRjSL8GrnDcIYaKwOgJHglJetBloL2L2MPmboUm-8_0uwxjgcrGElJ8qoeDJ9xS3McT2FD4-_Llotqn5bfvHh78fYdNDC3t_C0NM3dDaXRP78V2E9eD-Z6WX7a3Pu18-N_Y1eBFsm_2b6T4GPz9f_lhcVdffviwX8-vKMUlUpR0WWmCHFZWu7Kup49IKS4hwBJMgCNErrbiXQa5DCYKzNaFSr5gvRkWPwYd9322KN0OZbromO9-2tvdxyEZyxTBnohjP9kaXYs7JB1PW62y6NxiZEbXZmJGnGXmaEbWZUJu7Uvx2mjKsOr8-lE5si_5-0m12tg3J9q7JB5vSXAopi-18b7ttWn__hA-Y-df5JcZC0X8bLZsw</recordid><startdate>198412</startdate><enddate>198412</enddate><creator>CUMMINGS, G. C.</creator><creator>DIXON, J.</creator><creator>KAY, N. H.</creator><creator>WINDSOR, J. P. W.</creator><creator>MAJOR, E.</creator><creator>MORGAN, M.</creator><creator>SEAR, J. W.</creator><creator>SPENCE, A. A.</creator><creator>STEPHENSON, D. K.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198412</creationdate><title>Dose requirements of ICI 35,868 (Propofol, ‘Diprivan’) in a new formulation for induction of anaesthesia</title><author>CUMMINGS, G. C. ; DIXON, J. ; KAY, N. H. ; WINDSOR, J. P. W. ; MAJOR, E. ; MORGAN, M. ; SEAR, J. W. ; SPENCE, A. A. ; STEPHENSON, D. K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4728-9c16961c1837c11193c57a6a226c212f6229b985e7f7df7f7654d2379b4e57a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anaesthetics, intravenous</topic><topic>Anesthesia</topic><topic>Anesthesia, Intravenous</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anesthetics - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Depression, Chemical</topic><topic>Fat Emulsions, Intravenous</topic><topic>Female</topic><topic>General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Phenols - administration & dosage</topic><topic>Phenols - pharmacology</topic><topic>Propofol</topic><topic>Respiration - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CUMMINGS, G. C.</creatorcontrib><creatorcontrib>DIXON, J.</creatorcontrib><creatorcontrib>KAY, N. H.</creatorcontrib><creatorcontrib>WINDSOR, J. P. W.</creatorcontrib><creatorcontrib>MAJOR, E.</creatorcontrib><creatorcontrib>MORGAN, M.</creatorcontrib><creatorcontrib>SEAR, J. W.</creatorcontrib><creatorcontrib>SPENCE, A. A.</creatorcontrib><creatorcontrib>STEPHENSON, D. K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CUMMINGS, G. C.</au><au>DIXON, J.</au><au>KAY, N. H.</au><au>WINDSOR, J. P. W.</au><au>MAJOR, E.</au><au>MORGAN, M.</au><au>SEAR, J. W.</au><au>SPENCE, A. A.</au><au>STEPHENSON, D. K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dose requirements of ICI 35,868 (Propofol, ‘Diprivan’) in a new formulation for induction of anaesthesia</atitle><jtitle>Anaesthesia</jtitle><addtitle>Anaesthesia</addtitle><date>1984-12</date><risdate>1984</risdate><volume>39</volume><issue>12</issue><spage>1168</spage><epage>1171</epage><pages>1168-1171</pages><issn>0003-2409</issn><eissn>1365-2044</eissn><coden>ANASAB</coden><abstract>Summary
In order to avoid Cremophor‐related reactions and reduce the incidence of pain on injection, di‐isopropylphenol (ICI 35,868; propofol) has been reformulated as an emulsion. One hundred and fifteen patients received an induction dose of propofol in the new formulation. The dose required to induce anaesthesia in 95% of healthy, unpremedicated patients was 2.5 mg/kg. Induction was associated with a degree of cardiovascular and respiratory depression. There were no adverse reactions although there were a number of minor side‐effects. The incidence of pain on injection was low (3%) and the overall quality of induction was assessed as good or adequate in 92% of patients.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>6335003</pmid><doi>10.1111/j.1365-2044.1984.tb06425.x</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Anaesthetics, intravenous Anesthesia Anesthesia, Intravenous Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics - administration & dosage Biological and medical sciences Blood Pressure - drug effects Depression, Chemical Fat Emulsions, Intravenous Female General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation Heart Rate - drug effects Humans Male Medical sciences Middle Aged Phenols - administration & dosage Phenols - pharmacology Propofol Respiration - drug effects |
| title | Dose requirements of ICI 35,868 (Propofol, ‘Diprivan’) in a new formulation for induction of anaesthesia |
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