Tau-2 immunoreactivity of corpora amylacea in the human retina and optic nerve
To characterize the constituents of corpora amylacea in the human retina and optic nerve. Immunohistochemistry was performed on sections of retina, optic nerve, and brain tissue using antibodies against tau 1, tau-2, and amyloid precursor protein. Consistent anti-tau-2 immunoreactivity was noted in...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 1993-07, Vol.34 (8), p.2600-2603 |
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| creator | Loeffler, KU Edward, DP Tso, MO |
| description | To characterize the constituents of corpora amylacea in the human retina and optic nerve.
Immunohistochemistry was performed on sections of retina, optic nerve, and brain tissue using antibodies against tau 1, tau-2, and amyloid precursor protein.
Consistent anti-tau-2 immunoreactivity was noted in the corpora amylacea in the retina, optic nerve, and brain tissue, albeit with variations in pattern and intensity of staining. No immunoreactivity was observed with antibodies anti-tau 1 and anti-amyloid precursor protein.
Our findings suggest the accumulation of possibly abnormal tau-2 within the corpora amylacea, which may be either astrocytic or axonal in origin. |
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Immunohistochemistry was performed on sections of retina, optic nerve, and brain tissue using antibodies against tau 1, tau-2, and amyloid precursor protein.
Consistent anti-tau-2 immunoreactivity was noted in the corpora amylacea in the retina, optic nerve, and brain tissue, albeit with variations in pattern and intensity of staining. No immunoreactivity was observed with antibodies anti-tau 1 and anti-amyloid precursor protein.
Our findings suggest the accumulation of possibly abnormal tau-2 within the corpora amylacea, which may be either astrocytic or axonal in origin.</description><identifier>ISSN: 0146-0404</identifier><identifier>EISSN: 1552-5783</identifier><identifier>PMID: 7686896</identifier><identifier>CODEN: IOVSDA</identifier><language>eng</language><publisher>Rockville, MD: ARVO</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Alzheimer Disease - metabolism ; Alzheimer Disease - pathology ; Amyloid beta-Protein Precursor ; Biological and medical sciences ; Eye and associated structures. Visual pathways and centers. Vision ; Fundamental and applied biological sciences. Psychology ; Humans ; Immunoenzyme Techniques ; Immunohistochemistry ; Inclusion Bodies - metabolism ; Inclusion Bodies - pathology ; Microtubule-Associated Proteins ; Middle Aged ; Neurofibrillary Tangles - metabolism ; Neurofibrillary Tangles - pathology ; Optic Nerve - metabolism ; Optic Nerve - pathology ; Retina - metabolism ; Retina - pathology ; Staining and Labeling ; Vertebrates: nervous system and sense organs</subject><ispartof>Investigative ophthalmology & visual science, 1993-07, Vol.34 (8), p.2600-2603</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4831073$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7686896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Loeffler, KU</creatorcontrib><creatorcontrib>Edward, DP</creatorcontrib><creatorcontrib>Tso, MO</creatorcontrib><title>Tau-2 immunoreactivity of corpora amylacea in the human retina and optic nerve</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>To characterize the constituents of corpora amylacea in the human retina and optic nerve.
Immunohistochemistry was performed on sections of retina, optic nerve, and brain tissue using antibodies against tau 1, tau-2, and amyloid precursor protein.
Consistent anti-tau-2 immunoreactivity was noted in the corpora amylacea in the retina, optic nerve, and brain tissue, albeit with variations in pattern and intensity of staining. No immunoreactivity was observed with antibodies anti-tau 1 and anti-amyloid precursor protein.
Our findings suggest the accumulation of possibly abnormal tau-2 within the corpora amylacea, which may be either astrocytic or axonal in origin.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - pathology</subject><subject>Amyloid beta-Protein Precursor</subject><subject>Biological and medical sciences</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Immunohistochemistry</subject><subject>Inclusion Bodies - metabolism</subject><subject>Inclusion Bodies - pathology</subject><subject>Microtubule-Associated Proteins</subject><subject>Middle Aged</subject><subject>Neurofibrillary Tangles - metabolism</subject><subject>Neurofibrillary Tangles - pathology</subject><subject>Optic Nerve - metabolism</subject><subject>Optic Nerve - pathology</subject><subject>Retina - metabolism</subject><subject>Retina - pathology</subject><subject>Staining and Labeling</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0146-0404</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LxDAURYMo4zj6E4QsxF0hTdI0XcrgFwy6GdfhNUltpEnHpJ0y_96CRVdvcQ73Xt4ZWudFQbOilOwcrUnORUY44ZfoKqUvQmieU7JCq1JIISuxRm97GDOKnfdj6KMFPbijG064b7Du46GPgMGfOtAWsAt4aC1uRw8BRzu4MMNgcH8YnMbBxqO9RhcNdMneLHeDPp4e99uXbPf-_Lp92GUtFWLIaA1AgRijOSsqS0AbKUwtc14LqrlmlWANFZyXlhppqCAlJ0VVA9WkahrDNuj-N_cQ--_RpkF5l7TtOgi2H5MqC8mqqiSzeLuIY-2tUYfoPMSTWh4w87uFQ9LQNRGCdulP45LlpGT_fa37bCcXrUoeum4OzdU0TYwrqeaVhP0ALGhx_g</recordid><startdate>19930701</startdate><enddate>19930701</enddate><creator>Loeffler, KU</creator><creator>Edward, DP</creator><creator>Tso, MO</creator><general>ARVO</general><general>Association for Research in Vision and Ophtalmology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19930701</creationdate><title>Tau-2 immunoreactivity of corpora amylacea in the human retina and optic nerve</title><author>Loeffler, KU ; Edward, DP ; Tso, MO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h266t-2baa2a0ddc4359e0acd86db814b62c4c3963f26447e2d8d26074059ba2c09ffd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - pathology</topic><topic>Amyloid beta-Protein Precursor</topic><topic>Biological and medical sciences</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Immunohistochemistry</topic><topic>Inclusion Bodies - metabolism</topic><topic>Inclusion Bodies - pathology</topic><topic>Microtubule-Associated Proteins</topic><topic>Middle Aged</topic><topic>Neurofibrillary Tangles - metabolism</topic><topic>Neurofibrillary Tangles - pathology</topic><topic>Optic Nerve - metabolism</topic><topic>Optic Nerve - pathology</topic><topic>Retina - metabolism</topic><topic>Retina - pathology</topic><topic>Staining and Labeling</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Loeffler, KU</creatorcontrib><creatorcontrib>Edward, DP</creatorcontrib><creatorcontrib>Tso, MO</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Loeffler, KU</au><au>Edward, DP</au><au>Tso, MO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tau-2 immunoreactivity of corpora amylacea in the human retina and optic nerve</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>1993-07-01</date><risdate>1993</risdate><volume>34</volume><issue>8</issue><spage>2600</spage><epage>2603</epage><pages>2600-2603</pages><issn>0146-0404</issn><eissn>1552-5783</eissn><coden>IOVSDA</coden><abstract>To characterize the constituents of corpora amylacea in the human retina and optic nerve.
Immunohistochemistry was performed on sections of retina, optic nerve, and brain tissue using antibodies against tau 1, tau-2, and amyloid precursor protein.
Consistent anti-tau-2 immunoreactivity was noted in the corpora amylacea in the retina, optic nerve, and brain tissue, albeit with variations in pattern and intensity of staining. No immunoreactivity was observed with antibodies anti-tau 1 and anti-amyloid precursor protein.
Our findings suggest the accumulation of possibly abnormal tau-2 within the corpora amylacea, which may be either astrocytic or axonal in origin.</abstract><cop>Rockville, MD</cop><pub>ARVO</pub><pmid>7686896</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Investigative ophthalmology & visual science, 1993-07, Vol.34 (8), p.2600-2603 |
| issn | 0146-0404 1552-5783 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid beta-Protein Precursor Biological and medical sciences Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Humans Immunoenzyme Techniques Immunohistochemistry Inclusion Bodies - metabolism Inclusion Bodies - pathology Microtubule-Associated Proteins Middle Aged Neurofibrillary Tangles - metabolism Neurofibrillary Tangles - pathology Optic Nerve - metabolism Optic Nerve - pathology Retina - metabolism Retina - pathology Staining and Labeling Vertebrates: nervous system and sense organs |
| title | Tau-2 immunoreactivity of corpora amylacea in the human retina and optic nerve |
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