Deacylation-Reacylation Cycle: A Possible Absorption Mechanism for the Novel Lymphotropic Antitumor Agent Dipalmitoylphosphatidylfluorouridine in Rats

Dipalmitoylphosphatidylfluorouridine (DPPF) is a potent antitumor agent that selectively gains access to the lymphatic system. To determine whether DPPF enters the lymph in an unmodified form, we administered DPPF orally to rats and analyzed lymph collected from a cannula in the thoracic duct. Altho...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1993-06, Vol.82 (6), p.575-578
Hauptverfasser:	Sakai, Atsushi, Mori, Nobuhiro, Shuto, Satoshi, Suzuki, Tadakiyo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Administration, Oral Animals Antineoplastic agents Antineoplastic Agents - pharmacokinetics Biological and medical sciences Chromatography, High Pressure Liquid General aspects Glycerophospholipids Intestinal Absorption Lymph - metabolism Lymphatic System - metabolism Male Medical sciences Pharmacology. Drug treatments Phosphatidic Acids - chemistry Phosphatidic Acids - isolation & purification Phosphatidic Acids - pharmacokinetics Rats Rats, Wistar Spectrometry, Mass, Fast Atom Bombardment Thoracic Duct - metabolism Uridine - analogs & derivatives Uridine - chemistry Uridine - isolation & purification Uridine - pharmacokinetics
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