Experimental models in primates for reconstructive surgery utilizing tissue transplants
Two experimental models for tissue transplantation between unrelated individuals of a primate species have been designed to study survival and reinnervation. The first is a neurovascular free flap consisting of the entire soft tissue coverage of the index finger. The second is an entire hand transpl...
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| Veröffentlicht in: | Annals of plastic surgery 1984-11, Vol.13 (5), p.423-430 |
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| container_title | Annals of plastic surgery |
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| creator | EGERSZEGI, E. P SAMULACK, D. D DANIEL, R. K |
| description | Two experimental models for tissue transplantation between unrelated individuals of a primate species have been designed to study survival and reinnervation. The first is a neurovascular free flap consisting of the entire soft tissue coverage of the index finger. The second is an entire hand transplant through the distal forearm. Ongoing studies show that cyclosporin A at high doses, in combination with a tapering regimen of steroids to a low maintenance level, permits prolonged survival of both transplant models. Careful biochemical, hematological, and cyclosporin A serum trough level monitoring permits use of this drug a very high dosages in primates. Continuing experiments should yield detailed neurophysiological data on the reinnervation of these transplants over the next 6 to 18 months. |
| doi_str_mv | 10.1097/00000637-198411000-00010 |
| format | Article |
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P ; SAMULACK, D. D ; DANIEL, R. K</creator><creatorcontrib>EGERSZEGI, E. P ; SAMULACK, D. D ; DANIEL, R. K</creatorcontrib><description>Two experimental models for tissue transplantation between unrelated individuals of a primate species have been designed to study survival and reinnervation. The first is a neurovascular free flap consisting of the entire soft tissue coverage of the index finger. The second is an entire hand transplant through the distal forearm. Ongoing studies show that cyclosporin A at high doses, in combination with a tapering regimen of steroids to a low maintenance level, permits prolonged survival of both transplant models. Careful biochemical, hematological, and cyclosporin A serum trough level monitoring permits use of this drug a very high dosages in primates. Continuing experiments should yield detailed neurophysiological data on the reinnervation of these transplants over the next 6 to 18 months.</description><identifier>ISSN: 0148-7043</identifier><identifier>EISSN: 1536-3708</identifier><identifier>DOI: 10.1097/00000637-198411000-00010</identifier><identifier>PMID: 6393844</identifier><identifier>CODEN: APCSD4</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Biological and medical sciences ; Cyclosporins - therapeutic use ; Hand - innervation ; Hand - surgery ; Hand Transplantation ; History of medicine ; History, 19th Century ; History, 20th Century ; Immunosuppression ; Intraoperative Care ; Medical sciences ; Orthopedic surgery ; Papio ; Postoperative Care ; Skin Transplantation ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgical Flaps ; Transplantation - history ; Transplantation Immunology ; Transplantation, Heterologous ; Transplantation, Homologous</subject><ispartof>Annals of plastic surgery, 1984-11, Vol.13 (5), p.423-430</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-77779d5d528e0f8f9daa74e6677e499bd8f8f653d877f00b99549e027695e6cf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8924880$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6393844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>EGERSZEGI, E. P</creatorcontrib><creatorcontrib>SAMULACK, D. D</creatorcontrib><creatorcontrib>DANIEL, R. K</creatorcontrib><title>Experimental models in primates for reconstructive surgery utilizing tissue transplants</title><title>Annals of plastic surgery</title><addtitle>Ann Plast Surg</addtitle><description>Two experimental models for tissue transplantation between unrelated individuals of a primate species have been designed to study survival and reinnervation. The first is a neurovascular free flap consisting of the entire soft tissue coverage of the index finger. The second is an entire hand transplant through the distal forearm. Ongoing studies show that cyclosporin A at high doses, in combination with a tapering regimen of steroids to a low maintenance level, permits prolonged survival of both transplant models. Careful biochemical, hematological, and cyclosporin A serum trough level monitoring permits use of this drug a very high dosages in primates. Continuing experiments should yield detailed neurophysiological data on the reinnervation of these transplants over the next 6 to 18 months.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cyclosporins - therapeutic use</subject><subject>Hand - innervation</subject><subject>Hand - surgery</subject><subject>Hand Transplantation</subject><subject>History of medicine</subject><subject>History, 19th Century</subject><subject>History, 20th Century</subject><subject>Immunosuppression</subject><subject>Intraoperative Care</subject><subject>Medical sciences</subject><subject>Orthopedic surgery</subject><subject>Papio</subject><subject>Postoperative Care</subject><subject>Skin Transplantation</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgical Flaps</subject><subject>Transplantation - history</subject><subject>Transplantation Immunology</subject><subject>Transplantation, Heterologous</subject><subject>Transplantation, Homologous</subject><issn>0148-7043</issn><issn>1536-3708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kNtKAzEQhoMotVYfQciFeLeabLI5XEqpByh4o3i5pLuzJbLdrZmsWJ_e9GAHwpCZ_59kPkIoZ3ecWX3PtqGEzrg1kvN0ydLh7ISMeSFUJjQzp2TMuDSZZlKckwvEz6TIjVQjMlLCCiPlmHzMftYQ_Aq66Fq66mtokfqOrlPNRUDa9IEGqPoOYxiq6L-B4hCWEDZ0iL71v75b0ugRB6AxuA7XresiXpKzxrUIV4c8Ie-Ps7fpczZ_fXqZPsyzSggbM53C1kVd5AZYYxpbO6clKKU1SGsXtUlFVYjaaN0wtrC2kBZYrpUtQFWNmJDb_dx16L8GwFiuPFbQpk9AP2CpCyO0ESYJzV5YhR4xQFPuVgybkrNyy7T8Z1oemZY7psl6fXhjWKygPhoPEFP_5tB3WLm2SRQqj0eZsbk0hok_Tu6APw</recordid><startdate>198411</startdate><enddate>198411</enddate><creator>EGERSZEGI, E. P</creator><creator>SAMULACK, D. D</creator><creator>DANIEL, R. K</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198411</creationdate><title>Experimental models in primates for reconstructive surgery utilizing tissue transplants</title><author>EGERSZEGI, E. P ; SAMULACK, D. D ; DANIEL, R. K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-77779d5d528e0f8f9daa74e6677e499bd8f8f653d877f00b99549e027695e6cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cyclosporins - therapeutic use</topic><topic>Hand - innervation</topic><topic>Hand - surgery</topic><topic>Hand Transplantation</topic><topic>History of medicine</topic><topic>History, 19th Century</topic><topic>History, 20th Century</topic><topic>Immunosuppression</topic><topic>Intraoperative Care</topic><topic>Medical sciences</topic><topic>Orthopedic surgery</topic><topic>Papio</topic><topic>Postoperative Care</topic><topic>Skin Transplantation</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgical Flaps</topic><topic>Transplantation - history</topic><topic>Transplantation Immunology</topic><topic>Transplantation, Heterologous</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EGERSZEGI, E. P</creatorcontrib><creatorcontrib>SAMULACK, D. D</creatorcontrib><creatorcontrib>DANIEL, R. K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of plastic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>EGERSZEGI, E. P</au><au>SAMULACK, D. D</au><au>DANIEL, R. K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental models in primates for reconstructive surgery utilizing tissue transplants</atitle><jtitle>Annals of plastic surgery</jtitle><addtitle>Ann Plast Surg</addtitle><date>1984-11</date><risdate>1984</risdate><volume>13</volume><issue>5</issue><spage>423</spage><epage>430</epage><pages>423-430</pages><issn>0148-7043</issn><eissn>1536-3708</eissn><coden>APCSD4</coden><abstract>Two experimental models for tissue transplantation between unrelated individuals of a primate species have been designed to study survival and reinnervation. The first is a neurovascular free flap consisting of the entire soft tissue coverage of the index finger. The second is an entire hand transplant through the distal forearm. Ongoing studies show that cyclosporin A at high doses, in combination with a tapering regimen of steroids to a low maintenance level, permits prolonged survival of both transplant models. Careful biochemical, hematological, and cyclosporin A serum trough level monitoring permits use of this drug a very high dosages in primates. Continuing experiments should yield detailed neurophysiological data on the reinnervation of these transplants over the next 6 to 18 months.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>6393844</pmid><doi>10.1097/00000637-198411000-00010</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0148-7043 |
| ispartof | Annals of plastic surgery, 1984-11, Vol.13 (5), p.423-430 |
| issn | 0148-7043 1536-3708 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Cyclosporins - therapeutic use Hand - innervation Hand - surgery Hand Transplantation History of medicine History, 19th Century History, 20th Century Immunosuppression Intraoperative Care Medical sciences Orthopedic surgery Papio Postoperative Care Skin Transplantation Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgical Flaps Transplantation - history Transplantation Immunology Transplantation, Heterologous Transplantation, Homologous |
| title | Experimental models in primates for reconstructive surgery utilizing tissue transplants |
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