Inhibition of axonal growth by SNAP-25 antisense oligonucleotides in vitro and in vivo
AXONAL elongation and the transformation of growth cones to synaptic terminals are major steps of brain development and the molecular mechanisms involved form the basis of the correct wiring of the nervous system. The same mechanisms may also contribute to the remodelling of nerve terminals that occ...
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| Veröffentlicht in: | Nature (London) 1993-07, Vol.364 (6436), p.445-448 |
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| creator | Osen-Sand, Astrid Catsicas, Marina Staple, Julie K Jones, Kenneth A Ayala, Guidon Knowles, Jonathan Grenningloh, Gabriele Catsicas, Stefan |
| description | AXONAL elongation and the transformation of growth cones to synaptic terminals are major steps of brain development and the molecular mechanisms involved form the basis of the correct wiring of the nervous system. The same mechanisms may also contribute to the remodelling of nerve terminals that occurs in the adult brain, as a morphological substrate to memory and learning
1
. We have investigated the function of the nerve terminal protein SNAP-25 (ref. 2) during development. We report here that SNAP-25 is expressed in axonal growth cones during late stages of elongation and that selective inhibition of SNAP-25 expression prevents neurite elongation by rat cortical neurons and PC-12 cells
in vitro
and by amacrine cells of the developing chick retina
in vivo
. These results demonstrate that SNAP-25 plays a key role in axonal growth. They also suggest that high levels of SNAP-25 expression in specific areas of the adult brain
2
may contribute to nerve terminal plasticity. |
| doi_str_mv | 10.1038/364445a0 |
| format | Article |
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1
. We have investigated the function of the nerve terminal protein SNAP-25 (ref. 2) during development. We report here that SNAP-25 is expressed in axonal growth cones during late stages of elongation and that selective inhibition of SNAP-25 expression prevents neurite elongation by rat cortical neurons and PC-12 cells
in vitro
and by amacrine cells of the developing chick retina
in vivo
. These results demonstrate that SNAP-25 plays a key role in axonal growth. They also suggest that high levels of SNAP-25 expression in specific areas of the adult brain
2
may contribute to nerve terminal plasticity.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/364445a0</identifier><identifier>PMID: 8332215</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Animals, Newborn ; Axons - physiology ; Base Sequence ; Biological and medical sciences ; Biology ; Brain ; Cells, Cultured ; Chick Embryo ; Fundamental and applied biological sciences. Psychology ; Humanities and Social Sciences ; Isolated neuron and nerve. Neuroglia ; letter ; Membrane Proteins ; Molecular Sequence Data ; multidisciplinary ; Nerve Growth Factors ; Nerve Tissue Proteins - biosynthesis ; Nerve Tissue Proteins - physiology ; Nervous system ; Neurites - physiology ; Neurons - metabolism ; Oligonucleotides, Antisense ; PC12 Cells ; Proteins ; Rats ; Retina - embryology ; Retina - metabolism ; Science ; Science (multidisciplinary) ; Synaptosomal-Associated Protein 25 ; Thionucleotides ; Vertebrates: nervous system and sense organs</subject><ispartof>Nature (London), 1993-07, Vol.364 (6436), p.445-448</ispartof><rights>Springer Nature Limited 1993</rights><rights>1993 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Jul 29, 1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-dbf7b72ad06f545691e8d1c3448ceafafee8c9f57f8e5d2a50685b053b5747db3</citedby><cites>FETCH-LOGICAL-c521t-dbf7b72ad06f545691e8d1c3448ceafafee8c9f57f8e5d2a50685b053b5747db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,2728,27926,27927</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4830678$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8332215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Osen-Sand, Astrid</creatorcontrib><creatorcontrib>Catsicas, Marina</creatorcontrib><creatorcontrib>Staple, Julie K</creatorcontrib><creatorcontrib>Jones, Kenneth A</creatorcontrib><creatorcontrib>Ayala, Guidon</creatorcontrib><creatorcontrib>Knowles, Jonathan</creatorcontrib><creatorcontrib>Grenningloh, Gabriele</creatorcontrib><creatorcontrib>Catsicas, Stefan</creatorcontrib><title>Inhibition of axonal growth by SNAP-25 antisense oligonucleotides in vitro and in vivo</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>AXONAL elongation and the transformation of growth cones to synaptic terminals are major steps of brain development and the molecular mechanisms involved form the basis of the correct wiring of the nervous system. The same mechanisms may also contribute to the remodelling of nerve terminals that occurs in the adult brain, as a morphological substrate to memory and learning
1
. We have investigated the function of the nerve terminal protein SNAP-25 (ref. 2) during development. We report here that SNAP-25 is expressed in axonal growth cones during late stages of elongation and that selective inhibition of SNAP-25 expression prevents neurite elongation by rat cortical neurons and PC-12 cells
in vitro
and by amacrine cells of the developing chick retina
in vivo
. These results demonstrate that SNAP-25 plays a key role in axonal growth. They also suggest that high levels of SNAP-25 expression in specific areas of the adult brain
2
may contribute to nerve terminal plasticity.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Axons - physiology</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Biology</subject><subject>Brain</subject><subject>Cells, Cultured</subject><subject>Chick Embryo</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humanities and Social Sciences</subject><subject>Isolated neuron and nerve. Neuroglia</subject><subject>letter</subject><subject>Membrane Proteins</subject><subject>Molecular Sequence Data</subject><subject>multidisciplinary</subject><subject>Nerve Growth Factors</subject><subject>Nerve Tissue Proteins - biosynthesis</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>Nervous system</subject><subject>Neurites - physiology</subject><subject>Neurons - metabolism</subject><subject>Oligonucleotides, Antisense</subject><subject>PC12 Cells</subject><subject>Proteins</subject><subject>Rats</subject><subject>Retina - embryology</subject><subject>Retina - metabolism</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Synaptosomal-Associated Protein 25</subject><subject>Thionucleotides</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0V1rFDEUBuAgSl3Xgn_AEoqIXozNd7KXpVQtFBVsvR0ymZNtymzSJjP9-Pem7LoFkXoVwnl4E86L0BtKPlHCzQFXQghpyTM0o0KrRiijn6MZIcw0xHD1Er0q5ZIQIqkWO2jHcM4YlTP06yRehC6MIUWcPLZ3KdoBL3O6HS9wd49_fjv80TCJbRxDgVgApyEsU5zcAGkMPRQcIr4JY07V9OvLTXqNXng7FNjdnHN0_vn47Ohrc_r9y8nR4WnjJKNj03ded5rZnigvhVQLCqanjgthHFhvPYBxCy-1NyB7ZiVRRnZE8k5qofuOz9H7de5VTtcTlLFdheJgGGyENJVWS8O1ZPy_kKqFMoI8wA9Pw7pSUh-vdo72_6KXacp1f6VlpNahhZKPeS6nUjL49iqHlc33Nal96K79012lbzd5U7eCfgs3ZdX5u83cFmcHn210oWyZMJwobSr7uGalTuIS8uO3_vHk3tpGO04Ztllb8Bsyr7Xn</recordid><startdate>19930729</startdate><enddate>19930729</enddate><creator>Osen-Sand, Astrid</creator><creator>Catsicas, Marina</creator><creator>Staple, Julie K</creator><creator>Jones, Kenneth A</creator><creator>Ayala, Guidon</creator><creator>Knowles, Jonathan</creator><creator>Grenningloh, Gabriele</creator><creator>Catsicas, Stefan</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>19930729</creationdate><title>Inhibition of axonal growth by SNAP-25 antisense oligonucleotides in vitro and in vivo</title><author>Osen-Sand, Astrid ; 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Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Osen-Sand, Astrid</au><au>Catsicas, Marina</au><au>Staple, Julie K</au><au>Jones, Kenneth A</au><au>Ayala, Guidon</au><au>Knowles, Jonathan</au><au>Grenningloh, Gabriele</au><au>Catsicas, Stefan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of axonal growth by SNAP-25 antisense oligonucleotides in vitro and in vivo</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1993-07-29</date><risdate>1993</risdate><volume>364</volume><issue>6436</issue><spage>445</spage><epage>448</epage><pages>445-448</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>AXONAL elongation and the transformation of growth cones to synaptic terminals are major steps of brain development and the molecular mechanisms involved form the basis of the correct wiring of the nervous system. The same mechanisms may also contribute to the remodelling of nerve terminals that occurs in the adult brain, as a morphological substrate to memory and learning
1
. We have investigated the function of the nerve terminal protein SNAP-25 (ref. 2) during development. We report here that SNAP-25 is expressed in axonal growth cones during late stages of elongation and that selective inhibition of SNAP-25 expression prevents neurite elongation by rat cortical neurons and PC-12 cells
in vitro
and by amacrine cells of the developing chick retina
in vivo
. These results demonstrate that SNAP-25 plays a key role in axonal growth. They also suggest that high levels of SNAP-25 expression in specific areas of the adult brain
2
may contribute to nerve terminal plasticity.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>8332215</pmid><doi>10.1038/364445a0</doi><tpages>4</tpages></addata></record> |
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| ispartof | Nature (London), 1993-07, Vol.364 (6436), p.445-448 |
| issn | 0028-0836 1476-4687 |
| language | eng |
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| source | MEDLINE; Nature Journals; Alma/SFX Local Collection |
| subjects | Animals Animals, Newborn Axons - physiology Base Sequence Biological and medical sciences Biology Brain Cells, Cultured Chick Embryo Fundamental and applied biological sciences. Psychology Humanities and Social Sciences Isolated neuron and nerve. Neuroglia letter Membrane Proteins Molecular Sequence Data multidisciplinary Nerve Growth Factors Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - physiology Nervous system Neurites - physiology Neurons - metabolism Oligonucleotides, Antisense PC12 Cells Proteins Rats Retina - embryology Retina - metabolism Science Science (multidisciplinary) Synaptosomal-Associated Protein 25 Thionucleotides Vertebrates: nervous system and sense organs |
| title | Inhibition of axonal growth by SNAP-25 antisense oligonucleotides in vitro and in vivo |
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